CN203643412U - Static axial compression column assembling machine for preparative liquid chromatography - Google Patents
Static axial compression column assembling machine for preparative liquid chromatography Download PDFInfo
- Publication number
- CN203643412U CN203643412U CN201320812998.6U CN201320812998U CN203643412U CN 203643412 U CN203643412 U CN 203643412U CN 201320812998 U CN201320812998 U CN 201320812998U CN 203643412 U CN203643412 U CN 203643412U
- Authority
- CN
- China
- Prior art keywords
- static
- axial compression
- compression column
- hydraulic cylinder
- cylinder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
The utility model relates to a static axial compression column assembling machine for preparative liquid chromatography. The static axial compression column assembling machine comprises a bracket, a slurry tank, a static axial compression column, a pneumatic oil pump and a hydraulic cylinder, wherein the hydraulic cylinder is vertically mounted on the bracket; the slurry tank is arranged above the hydraulic cylinder; the static axial compression column is mounted above the slurry tank; a piston element capable of being detached from a piston rod is mounted at the top of the piston rod of the hydraulic cylinder; the slurry tank has an inner chamber into which the piston element can be pushed; the static axial compression column comprises a static column body, wherein the static column body has the inner chamber into which the piston element can be pushed, a notch is formed in the piston element, the notch is provided with a columnar part and a conical part, wherein the conical part of the notch penetrates through the piston element through a through slot. The static axial compression column assembling machine disclosed by the utility model has the advantages of guaranteeing a uniform medium and a constant pressure in a column bed of the static column body, guaranteeing preparation and separation effects, also greatly lowering the running cost of the equipment and being applicable to a lab and pilot scale research and development.
Description
Technical field
The utility model relates to static axial compression column packing column machine for a kind of liquid phantom preparing chromatogram.
Background technology
High performance liquid chromatography technology of preparing is a kind of isolation technics that can obtain high-purity compound, many pharmaceuticals researchers wish oneself to have a set of preparative chromatography equipment, to carry out the development of production technology and technique for applying on chemico-analytic basis.
With analyzing, chromatogram is the same, and chromatographic column is the core component of chromatographic system.The post bed height of modern high performance liquid preparative chromatography post generally equates with conventional analysis post, is generally 250mm, and fundamental purpose is the difficulty that the manufacturability in order to reduce from analyzing preparation is amplified.At present, in preparative chromatography industry, applying more is dynamic axial compression column (DAC), in use, piston in chromatographic column relies on and is attached thereto the hydraulic jack connecing and produces all the time a relatively constant pressure compression post bed fillers, eliminates at any time in elution process the dead space producing because filler particles relatively moves.Dynamic axial compression column uses good, can meet the purifies and separates requirement of a lot of target products, and maximum advantage is to be applicable to large-scale commercial production.But the manufacturability for the product in laboratory study stage separates, the dynamic axial compression column thick heaviness that seems, inconvenient operation, and also expensive.Because under lab, different objects, different processes, needs the carrier of different fillers as mutually fixing or fixing phase.
Utility model content
The technical problems to be solved in the utility model is: overcome the deficiencies in the prior art, static axial compression column packing column machine for a kind of liquid phantom preparing chromatogram is provided, pressure stability in compression leg process, assembles easy.
The utility model solves the technical scheme that its technical matters adopts: static axial compression column packing column machine for a kind of liquid phantom preparing chromatogram, comprise support, homogenate tank, static axial compression column, Pneumatic oil pump, hydraulic cylinder, the vertical state of described hydraulic cylinder is rack-mount, the piston rod of described hydraulic cylinder is driven by Pneumatic oil pump, described homogenate tank is positioned at hydraulic cylinder top, described static axial compression column is arranged on homogenate tank top, the piston rod part of described hydraulic cylinder is installed the piston piece that can depart from piston rod, described homogenate tank has the inner chamber that piston piece can be pushed, described static axial compression column has static cylinder, described static cylinder bottom removably connects with homogenate tank top, described static cylinder has the inner chamber that piston piece can be pushed, described static cylinder upper end is detachably provided with upper end cover, described piston piece is provided with notch, described notch has cylindrical section and tapering part, the tapering part of described notch connects piston piece by groove.
Further, described homogenate tank is fixedly mounted on support.
Further, between described static cylinder bottom and homogenate tank top, be connected by fast open chain fitting.
Further, described static cylinder upper end is connected by fast open chain fitting with upper end cover, and described upper end cover is provided with liquid outlet.
Further, after described static cylinder lower end separates with homogenate tank, bottom end cover can be installed, described static cylinder lower end is connected by fast open chain fitting with bottom end cover, and described bottom end cover is provided with liquid inlet.
The beneficial effects of the utility model are: the utility model has guaranteed homogeneous media, the constant pressure in the post bed of static cylinder, guarantee to prepare separating effect, greatly reduce equipment operating cost simultaneously, be applicable to the research and development of laboratory and pilot-scale, can load the static axial compression column of multiple different length specification, also can load different types of filler, be more suitable for the separating technology requirement of different products and different scales, dress post process is simple to operation, with low cost, especially easily obtain rapid promotion and application.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, the utility model is further illustrated.
Fig. 1 is structural representation of the present utility model;
Fig. 2 is the in running order schematic diagram of working for the moment of the utility model;
Fig. 3 is the utility model work schematic diagram of in running order 2 o'clock;
Fig. 4 is the utility model work schematic diagram of in running order 3 o'clock;
Fig. 5 is the structural representation of in running order 4 o'clock static axial compression columns of the utility model;
Wherein: 1, support, 2, homogenate tank, 3, static axial compression column, 31, static cylinder, 32, upper end cover, 33, bottom end cover, 4, Pneumatic oil pump, 5, hydraulic cylinder, 51, piston rod, 52, piston piece, 6, fast open chain fitting.
Embodiment
By reference to the accompanying drawings the utility model is further described now.The schematic diagram that these accompanying drawings are simplification only illustrates basic structure of the present utility model in a schematic way, and therefore it only shows the formation relevant with the utility model.
As shown in Figure 1, a kind of static axial compression column packing column machine for liquid phantom preparing chromatogram, comprise support 1, homogenate tank 2, static axial compression column 3, Pneumatic oil pump 4, hydraulic cylinder 5, the vertical state of hydraulic cylinder 5 is arranged on support 1, the piston rod 51 of hydraulic cylinder 5 is driven by Pneumatic oil pump 4, and Pneumatic oil pump 4 can manually be controlled or by controller control.Homogenate tank 2 is positioned at hydraulic cylinder 5 tops, homogenate tank 2 is fixedly mounted on support 1, static axial compression column 3 is arranged on homogenate tank 2 tops, the piston piece 52 that can depart from piston rod 51 is installed at piston rod 51 tops of hydraulic cylinder 5, homogenate tank 2 has the inner chamber that piston piece 52 can be pushed, static axial compression column 3 has static cylinder 31, between static cylinder 31 bottoms and homogenate tank 2 tops, be connected by fast open chain fitting 6, static cylinder 31 has the inner chamber that piston piece 52 can be pushed, static cylinder 31 upper ends are detachably provided with upper end cover 32, static cylinder 31 upper ends are connected by fast open chain fitting with upper end cover 32, upper end cover 32 is provided with liquid outlet.Piston piece 52 is provided with notch 521, and notch 521 has cylindrical section and tapering part, and the tapering part of notch connects piston piece by groove 522.After static cylinder 31 lower ends separate with homogenate tank 2, bottom end cover 33 can be installed, static cylinder 31 lower ends are connected by fast open chain fitting with bottom end cover 33, and bottom end cover 33 is provided with liquid inlet.
Liquid phantom preparing chromatogram illustrates by static axial compression column packing column machine duty:
Duty one:
As shown in Figure 2, hydraulic cylinder 5 does not drive, and piston piece 52 is connected with the piston rod 51 of hydraulic cylinder 5, and homogenate tank 2 is arranged on support 1, and homogenate tank 2 is positioned at hydraulic cylinder 5 tops.
Duty two:
As shown in Figure 3, Pneumatic oil pump 4 produces fluid pressure and drives the piston rod 51 of hydraulic cylinder 5 up, and piston piece 52 is pushed homogenate tank 2 by piston rod 51, and piston piece 52 bottoms are concordant with 2 end of homogenate tank mouth, permissible error 10mm.
Duty three:
As shown in Figure 4, to the interior injected media homogenate of homogenate tank 2, homogenate tank 2 tops connect static axial compression column 3.
Pneumatic oil pump 4 produces fluid pressure and drives the piston rod 51 of hydraulic cylinder 5 again up, piston rod 51 promotes piston piece 51 and enters in the static cylinder 31 of static axial compression column 3 through homogenate tank 2, stops and keeping constant pressure after the post bed in the static cylinders 31 of piston piece 52 compactings.Standing 30min back piston bar 51 promotes piston piece 52 and continues compacted pillar bed.
Duty four:
As shown in Figure 5, open the fast open chain fitting connecting between homogenate tank 2 and static cylinder 31, manually separate homogenate tank 2 and static axial compression column 3, piston piece 52 separates with piston rod 51 simultaneously, piston piece 52 is in static cylinder 31 inner chambers, bottom end cover 33, bottom end cover 33 clamping piston parts 52 are installed in static cylinder 31 lower ends.The inlet of closed lower lid 33, the liquid outlet of upper end cover 32 are stand-by.
The vertical state of hydraulic cylinder of the present utility model is rack-mount, piston rod is pushed into medium homogenate in the inner chamber of static cylinder together with piston piece from homogenate tank, adopt piston piece of the present utility model, piston piece can not only depart from easily with piston rod, and make to apply even, constant axle pressure, compacted pillar bed.Static post upper end cover, bottom end cover are respectively equipped with liquid outlet, inlet, conveniently carry out work connection.
The utility model has guaranteed homogeneous media, the constant pressure in the post bed of static cylinder, guarantee to prepare separating effect, greatly reduce equipment operating cost simultaneously, be applicable to the research and development of laboratory and pilot-scale, can load the static axial compression column of multiple different length specification, also can load different types of filler, be more suitable for the separating technology requirement of different products and different scales, dress post process is simple to operation, with low cost, especially easily obtains rapid promotion and application.
Take above-mentioned foundation desirable embodiment of the present utility model as enlightenment, by above-mentioned description, relevant staff can, not departing from the scope of this utility model technological thought, carry out various change and modification completely.The technical scope of this utility model is not limited to the content on instructions, must determine its technical scope according to claim scope.
Claims (4)
1. a static axial compression column packing column machine for liquid phantom preparing chromatogram, it is characterized in that: comprise support (1), homogenate tank (2), static axial compression column (3), Pneumatic oil pump (4), hydraulic cylinder (5), described hydraulic cylinder (5) vertically state is arranged on support (1), the piston rod (51) of described hydraulic cylinder (5) is driven by Pneumatic oil pump (4), described homogenate tank (2) is positioned at hydraulic cylinder (5) top, described static axial compression column (3) is arranged on homogenate tank (2) top, the piston piece (52) that can depart from piston rod is installed at piston rod (51) top of described hydraulic cylinder (5), described homogenate tank (2) has the inner chamber that piston piece (52) can be pushed, described static axial compression column (3) has static cylinder (31), described static cylinder (31) bottom removably connects with homogenate tank (2) top, described static cylinder (31) has the inner chamber that piston piece (52) can be pushed, described static cylinder (31) upper end is detachably provided with upper end cover (32), described piston piece (52) is provided with notch (521), described notch has cylindrical section and tapering part, the tapering part of described notch connects piston piece by groove (522).
2. static axial compression column packing column machine for liquid phantom preparing chromatogram according to claim 1, is characterized in that: between described static cylinder (31) bottom and homogenate tank (2) top, be connected by fast open chain fitting.
3. static axial compression column packing column machine for liquid phantom preparing chromatogram according to claim 1, is characterized in that: described static cylinder (31) upper end is connected by fast open chain fitting with upper end cover (32), and described upper end cover (32) is provided with liquid outlet.
4. static axial compression column packing column machine for liquid phantom preparing chromatogram according to claim 1, it is characterized in that: bottom end cover (33) can be installed after separating with homogenate tank (2) in described static cylinder (31) lower end, described static cylinder (31) lower end is connected by fast open chain fitting with bottom end cover (33), and described bottom end cover (33) is provided with liquid inlet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320812998.6U CN203643412U (en) | 2013-12-11 | 2013-12-11 | Static axial compression column assembling machine for preparative liquid chromatography |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320812998.6U CN203643412U (en) | 2013-12-11 | 2013-12-11 | Static axial compression column assembling machine for preparative liquid chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203643412U true CN203643412U (en) | 2014-06-11 |
Family
ID=50874647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320812998.6U Expired - Fee Related CN203643412U (en) | 2013-12-11 | 2013-12-11 | Static axial compression column assembling machine for preparative liquid chromatography |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203643412U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019501393A (en) * | 2016-01-06 | 2019-01-17 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | Method and apparatus for packing a chromatography column assembly |
| CN117233303A (en) * | 2023-11-13 | 2023-12-15 | 维慕曦生物科技(常州)有限公司 | Automatic filling device for liquid chromatographic column |
-
2013
- 2013-12-11 CN CN201320812998.6U patent/CN203643412U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019501393A (en) * | 2016-01-06 | 2019-01-17 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | Method and apparatus for packing a chromatography column assembly |
| JP7070982B2 (en) | 2016-01-06 | 2022-05-18 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | Methods and equipment for filling chromatographic column assemblies |
| CN117233303A (en) * | 2023-11-13 | 2023-12-15 | 维慕曦生物科技(常州)有限公司 | Automatic filling device for liquid chromatographic column |
| CN117233303B (en) * | 2023-11-13 | 2024-01-19 | 维慕曦生物科技(常州)有限公司 | Automatic filling device for liquid chromatographic column |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN203643412U (en) | Static axial compression column assembling machine for preparative liquid chromatography | |
| CN203634859U (en) | Static axial compression column assembling machine | |
| CN204495556U (en) | A kind of chain wear contrast test machine | |
| CN104236881A (en) | Rigid damping testing device | |
| CN203765515U (en) | Tool used for maintaining oil cylinder | |
| CN203634860U (en) | Solid-phase extraction column filling device | |
| CN102990961A (en) | Large-scale vertical hydraulic machine with small floor area | |
| CN104707360A (en) | Static axial compression column assembling machine | |
| CN104707361A (en) | Static axial compression column assembling machine | |
| CN202136832U (en) | Normal pressure column chromatography device under closed environment | |
| CN203090528U (en) | Internal energy-storing constant pressure preparative column apparatus | |
| CN207051018U (en) | One kind detection sampling mechanism | |
| CN203804898U (en) | Tool for disassembling valve seat of plunger pump | |
| CN102836572A (en) | Double-cavity dynamic compression column for chromatographic separation | |
| CN209012174U (en) | Servo electric cylinders formula purifies and separates system | |
| CN203447822U (en) | Chromatographic column suitable for 96-well tissue culture plate | |
| CN207056088U (en) | A kind of syringe filter support | |
| CN209280652U (en) | A kind of column filler that can quickly load chromatographic column | |
| CN209967746U (en) | Column assembling device for chromatographic column | |
| CN202345942U (en) | Packing device for aligning steel tubes | |
| CN201394922Y (en) | Two-beam and three-column medicine pressing hydraulic press with vacuity control function | |
| CN102989199B (en) | Inner storage constant-pressure preparative column device | |
| CN206648937U (en) | A kind of wood adhesive glue-joint strength novel test device | |
| CN202886068U (en) | Water leakage detecting device | |
| CN202061418U (en) | Purification device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140611 Termination date: 20141211 |
|
| EXPY | Termination of patent right or utility model |