NL2031325B1 - Novel zinc finger degron sequences - Google Patents

Novel zinc finger degron sequences Download PDF

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Publication number
NL2031325B1
NL2031325B1 NL2031325A NL2031325A NL2031325B1 NL 2031325 B1 NL2031325 B1 NL 2031325B1 NL 2031325 A NL2031325 A NL 2031325A NL 2031325 A NL2031325 A NL 2031325A NL 2031325 B1 NL2031325 B1 NL 2031325B1
Authority
NL
Netherlands
Prior art keywords
zinc finger
finger domain
hybrid
amino acid
leu
Prior art date
Application number
NL2031325A
Other languages
English (en)
Dutch (nl)
Inventor
Nicolaas Maria Schumacher Antonius
Can Sahillioglu Ali
Original Assignee
Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis filed Critical Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis
Priority to NL2031325A priority Critical patent/NL2031325B1/en
Priority to IL315649A priority patent/IL315649A/en
Priority to CA3255620A priority patent/CA3255620A1/en
Priority to AU2023233426A priority patent/AU2023233426A1/en
Priority to US18/845,540 priority patent/US20250206789A1/en
Priority to CN202380027768.5A priority patent/CN118922547A/zh
Priority to PCT/NL2023/050136 priority patent/WO2023177296A1/en
Priority to EP23714358.1A priority patent/EP4493696A1/en
Priority to JP2024555386A priority patent/JP2025509853A/ja
Application granted granted Critical
Publication of NL2031325B1 publication Critical patent/NL2031325B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NL2031325A 2022-03-18 2022-03-18 Novel zinc finger degron sequences NL2031325B1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
NL2031325A NL2031325B1 (en) 2022-03-18 2022-03-18 Novel zinc finger degron sequences
IL315649A IL315649A (en) 2022-03-18 2023-03-17 Zinc finger dagron sequences
CA3255620A CA3255620A1 (en) 2022-03-18 2023-03-17 ZINC FINGER DEGRON SEQUENCES
AU2023233426A AU2023233426A1 (en) 2022-03-18 2023-03-17 Zinc finger degron sequences
US18/845,540 US20250206789A1 (en) 2022-03-18 2023-03-17 Zinc finger degron sequences
CN202380027768.5A CN118922547A (zh) 2022-03-18 2023-03-17 锌指降解决定子序列
PCT/NL2023/050136 WO2023177296A1 (en) 2022-03-18 2023-03-17 Zinc finger degron sequences
EP23714358.1A EP4493696A1 (en) 2022-03-18 2023-03-17 Zinc finger degron sequences
JP2024555386A JP2025509853A (ja) 2022-03-18 2023-03-17 ジンクフィンガーデグロン配列

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL2031325A NL2031325B1 (en) 2022-03-18 2022-03-18 Novel zinc finger degron sequences

Publications (1)

Publication Number Publication Date
NL2031325B1 true NL2031325B1 (en) 2023-09-29

Family

ID=82483007

Family Applications (1)

Application Number Title Priority Date Filing Date
NL2031325A NL2031325B1 (en) 2022-03-18 2022-03-18 Novel zinc finger degron sequences

Country Status (9)

Country Link
US (1) US20250206789A1 (https=)
EP (1) EP4493696A1 (https=)
JP (1) JP2025509853A (https=)
CN (1) CN118922547A (https=)
AU (1) AU2023233426A1 (https=)
CA (1) CA3255620A1 (https=)
IL (1) IL315649A (https=)
NL (1) NL2031325B1 (https=)
WO (1) WO2023177296A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024117904A1 (en) 2022-11-29 2024-06-06 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Receptor- and drug-dependent regulated on-site production of biologicals

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2037809B1 (en) 2024-05-29 2025-12-12 Cell Control Biotherapeutics Inc Loop reinforcement expression system for improved cell therapy products

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019007869A1 (en) 2017-07-03 2019-01-10 Glaxosmithkline Intellectual Property Development Limited TARGETED DEGRADATION OF PROTEINS
WO2019089592A1 (en) 2017-10-31 2019-05-09 The General Hospital Corporation Molecular switch-mediated control of engineered cells
WO2020132039A2 (en) 2018-12-18 2020-06-25 Dana-Farber Cancer Institute, Inc. Peptide tags for ligand induced degradation of fusion proteins
WO2021008042A1 (zh) 2019-07-17 2021-01-21 中车大同电力机车有限公司 机车牵引装置及其调整方法
WO2021080427A1 (en) 2019-10-23 2021-04-29 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Chimeric polypeptide for regulating immune cells
WO2021188286A2 (en) 2020-02-28 2021-09-23 The Broad Institute, Inc. Zinc finger degradation domains

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019007869A1 (en) 2017-07-03 2019-01-10 Glaxosmithkline Intellectual Property Development Limited TARGETED DEGRADATION OF PROTEINS
WO2019089592A1 (en) 2017-10-31 2019-05-09 The General Hospital Corporation Molecular switch-mediated control of engineered cells
WO2020132039A2 (en) 2018-12-18 2020-06-25 Dana-Farber Cancer Institute, Inc. Peptide tags for ligand induced degradation of fusion proteins
WO2021008042A1 (zh) 2019-07-17 2021-01-21 中车大同电力机车有限公司 机车牵引装置及其调整方法
WO2021080427A1 (en) 2019-10-23 2021-04-29 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Chimeric polypeptide for regulating immune cells
WO2021188286A2 (en) 2020-02-28 2021-09-23 The Broad Institute, Inc. Zinc finger degradation domains

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
AN ET AL., NAT COMMUN., vol. 8, 2017, pages 15398
CHUNG ET AL., NAT CHEM BIOL., vol. 11, no. 9, September 2015 (2015-09-01), pages 713 - 20
FEDOTOVA ET AL., ACTANATURAE, vol. 9, no. 2, pages 47 - 58
FENK ET AL., CLIN CANCER RES., vol. 26, no. 22, 15 November 2020 (2020-11-15), pages 5879 - 5886
GIBSON ET AL., NAT METHODS., vol. 6, no. 5, May 2009 (2009-05-01), pages 343 - 5
HAUGWITZ ET AL., BIOTECHNIQUES, vol. 44, no. 3, March 2008 (2008-03-01), pages 432 - 3
HU ET AL., CHEMBIOCHEM, 8 September 2021 (2021-09-08)
JAN ET AL., SCI TRANSL MED., vol. 13, no. 575, 6 January 2021 (2021-01-06), pages eabb6295
KODURI ET AL., PNAS, vol. 116, no. 7, 2019, pages 2539 - 2544
KVISTBORG ET AL., ONCOIMMUNOLOGY, vol. 1, no. 4, 1 July 2012 (2012-07-01), pages 409 - 418
LANIER ET AL., NAT IMMUNOL., vol. 9, no. 5, May 2008 (2008-05-01), pages 495 - 502
NABET ET AL., NAT CHEM BIOL., vol. 14, no. 5, May 2018 (2018-05-01), pages 431 - 441
SAHILLIOGLU ET AL., HUM GENE THER., vol. 32, no. 19-20, October 2021 (2021-10-01), pages 1029 - 1043
SIEVERS ET AL., SCIENCE, vol. 362, no. 6414, 2 November 2018 (2018-11-02), pages eaat0572
STRONEN ET AL., SCIENCE, vol. 352, no. 6291, 10 June 2016 (2016-06-10), pages 1337 - 41
TAN ET AL., PLOS ONE., vol. 12, no. 7, 2017, pages e0181578

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024117904A1 (en) 2022-11-29 2024-06-06 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Receptor- and drug-dependent regulated on-site production of biologicals

Also Published As

Publication number Publication date
EP4493696A1 (en) 2025-01-22
US20250206789A1 (en) 2025-06-26
CN118922547A (zh) 2024-11-08
WO2023177296A1 (en) 2023-09-21
AU2023233426A1 (en) 2024-10-31
JP2025509853A (ja) 2025-04-11
CA3255620A1 (en) 2023-09-21
IL315649A (en) 2024-11-01

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