JP2025509853A - ジンクフィンガーデグロン配列 - Google Patents

ジンクフィンガーデグロン配列 Download PDF

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Publication number
JP2025509853A
JP2025509853A JP2024555386A JP2024555386A JP2025509853A JP 2025509853 A JP2025509853 A JP 2025509853A JP 2024555386 A JP2024555386 A JP 2024555386A JP 2024555386 A JP2024555386 A JP 2024555386A JP 2025509853 A JP2025509853 A JP 2025509853A
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JP
Japan
Prior art keywords
zinc finger
finger domain
hybrid
amino acid
cys2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024555386A
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English (en)
Japanese (ja)
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JP2025509853A5 (https=
Inventor
キャン サヒルリオグル アリ
ニコラス マリア シューマッハ アントニウス
Original Assignee
スティヒティング ヘット ネーデルランズ カンケル インスティテュート－アントニ ファン レーウェンフーク ジーケンハウス
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Application filed by スティヒティング ヘット ネーデルランズ カンケル インスティテュート－アントニ ファン レーウェンフーク ジーケンハウス filed Critical スティヒティング ヘット ネーデルランズ カンケル インスティテュート－アントニ ファン レーウェンフーク ジーケンハウス
Publication of JP2025509853A publication Critical patent/JP2025509853A/ja
Publication of JP2025509853A5 publication Critical patent/JP2025509853A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2024555386A 2022-03-18 2023-03-17 ジンクフィンガーデグロン配列 Pending JP2025509853A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2031325 2022-03-18
NL2031325A NL2031325B1 (en) 2022-03-18 2022-03-18 Novel zinc finger degron sequences
PCT/NL2023/050136 WO2023177296A1 (en) 2022-03-18 2023-03-17 Zinc finger degron sequences

Publications (2)

Publication Number Publication Date
JP2025509853A true JP2025509853A (ja) 2025-04-11
JP2025509853A5 JP2025509853A5 (https=) 2026-02-25

Family

ID=82483007

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024555386A Pending JP2025509853A (ja) 2022-03-18 2023-03-17 ジンクフィンガーデグロン配列

Country Status (9)

Country Link
US (1) US20250206789A1 (https=)
EP (1) EP4493696A1 (https=)
JP (1) JP2025509853A (https=)
CN (1) CN118922547A (https=)
AU (1) AU2023233426A1 (https=)
CA (1) CA3255620A1 (https=)
IL (1) IL315649A (https=)
NL (1) NL2031325B1 (https=)
WO (1) WO2023177296A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2033636B1 (en) 2022-11-29 2024-06-04 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Receptor- and drug-dependent regulated on-site production of biologicals.
NL2037809B1 (en) 2024-05-29 2025-12-12 Cell Control Biotherapeutics Inc Loop reinforcement expression system for improved cell therapy products

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201710620D0 (en) 2017-07-03 2017-08-16 Glaxosmithkline Intellectual Property Ltd Targeted protein degradation
US12049482B2 (en) 2017-10-31 2024-07-30 The Brigham And Women's Hospital, Inc. Molecular switch-mediated control of engineered cells
WO2020132039A2 (en) 2018-12-18 2020-06-25 Dana-Farber Cancer Institute, Inc. Peptide tags for ligand induced degradation of fusion proteins
CN111907552B (zh) 2019-07-17 2021-08-13 中车大同电力机车有限公司 机车牵引装置及其调整方法
EP4048301B1 (en) 2019-10-23 2024-09-18 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Chimeric polypeptide for regulating immune cells
US20230151342A1 (en) 2020-02-28 2023-05-18 The Broad Institute, Inc Zinc finger degradation domains

Also Published As

Publication number Publication date
EP4493696A1 (en) 2025-01-22
NL2031325B1 (en) 2023-09-29
US20250206789A1 (en) 2025-06-26
CN118922547A (zh) 2024-11-08
WO2023177296A1 (en) 2023-09-21
AU2023233426A1 (en) 2024-10-31
CA3255620A1 (en) 2023-09-21
IL315649A (en) 2024-11-01

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