NL2000376C2 - Piperidinederivaten. - Google Patents

Piperidinederivaten. Download PDF

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Publication number
NL2000376C2
NL2000376C2 NL2000376A NL2000376A NL2000376C2 NL 2000376 C2 NL2000376 C2 NL 2000376C2 NL 2000376 A NL2000376 A NL 2000376A NL 2000376 A NL2000376 A NL 2000376A NL 2000376 C2 NL2000376 C2 NL 2000376C2
Authority
NL
Netherlands
Prior art keywords
pharmaceutically acceptable
group
compound
ylmethoxy
acceptable salt
Prior art date
Application number
NL2000376A
Other languages
English (en)
Dutch (nl)
Other versions
NL2000376A1 (nl
Inventor
Patrick Michael O'brien
Kimberly Suzanne Para
Scott Edward Lazerwith
Michelle Marie Bruendl
Keri Lynn Greene
Allen Jennings Rex
Joe Nahra
Susan Mary Kult Sheehan
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NL2000376A1 publication Critical patent/NL2000376A1/nl
Application granted granted Critical
Publication of NL2000376C2 publication Critical patent/NL2000376C2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NL2000376A 2005-12-20 2006-12-15 Piperidinederivaten. NL2000376C2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75184505P 2005-12-20 2005-12-20
US75184505 2005-12-20

Publications (2)

Publication Number Publication Date
NL2000376A1 NL2000376A1 (nl) 2007-06-21
NL2000376C2 true NL2000376C2 (nl) 2007-10-24

Family

ID=38015373

Family Applications (2)

Application Number Title Priority Date Filing Date
NL2000376A NL2000376C2 (nl) 2005-12-20 2006-12-15 Piperidinederivaten.
NL2000937A NL2000937C2 (nl) 2005-12-20 2007-10-15 Piperidinederivaten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL2000937A NL2000937C2 (nl) 2005-12-20 2007-10-15 Piperidinederivaten.

Country Status (12)

Country Link
US (1) US20070142389A1 (https=)
EP (1) EP1966137A2 (https=)
JP (1) JP2009520018A (https=)
AR (1) AR058110A1 (https=)
CA (1) CA2634172A1 (https=)
DO (1) DOP2006000287A (https=)
GT (1) GT200600516A (https=)
NL (2) NL2000376C2 (https=)
PE (1) PE20071005A1 (https=)
TW (1) TW200732304A (https=)
UY (1) UY30029A1 (https=)
WO (1) WO2007072150A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642583B2 (en) 2008-10-30 2014-02-04 Janssen Pharmaceutica Nv Serotonin receptor modulators
US8575364B2 (en) 2008-10-30 2013-11-05 Janssen Pharmaceutica Nv Modulators of serotonin receptor
US8304433B2 (en) 2008-11-14 2012-11-06 Theravance, Inc. Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound
WO2011085291A1 (en) 2010-01-11 2011-07-14 Theravance, Inc. 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors
ES2576082T3 (es) * 2012-01-31 2016-07-05 Eisai R&D Management Co., Ltd. Derivado de paroxetina
PT3344248T (pt) * 2015-09-02 2022-06-29 Trevena Inc Compostos moduladores do recetor opioide delta contendo aza-heterocíclicos de 6 membros, composições compreendendo os mesmos e seus usos
US11225487B2 (en) 2017-02-17 2022-01-18 Trevena, Inc. 7-membered aza-heterocyclic containing δ-opioid receptor modulating compounds, methods of using and making the same
BR112019016827A2 (pt) 2017-02-17 2020-04-07 Trevena Inc compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos
CN111533682B (zh) * 2020-05-29 2022-03-01 清华大学 帕罗西汀及其类似物的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3912743A (en) * 1973-01-30 1975-10-14 Ferrosan As 4-Phenylpiperidine compounds
EP0152273A2 (en) * 1984-02-07 1985-08-21 A/S Ferrosan A phenylpiperidine derivative, and its salts, their preparation, compositions containing them, and their therapeutic use
EP0190496A2 (en) * 1984-12-13 1986-08-13 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
EP0266574A2 (en) * 1986-11-03 1988-05-11 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0339579A2 (en) * 1988-04-28 1989-11-02 Novo Nordisk A/S Piperidine compositions and their preparation and use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE45511B1 (en) * 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
US5227379A (en) * 1986-11-03 1993-07-13 Novo Nordisk A/S Piperidine compounds and their preparation and use
US5017585A (en) * 1986-11-03 1991-05-21 Novo Nordisk A/S Method of treating calcium overload
IL98757A (en) * 1990-07-18 1997-01-10 Novo Nordisk As Piperidine derivatives their preparation and pharmaceutical compositions containing them
US5808139A (en) * 1992-04-21 1998-09-15 Ligand Pharmaceuticals Incorporated Non-steroid progesterone receptor agonist and antagonist and compounds and methods
US5914328A (en) * 1992-10-09 1999-06-22 Abbott Laboratories Heterocyclic ether compounds useful in controlling neurotransmitter release
RU2167865C2 (ru) * 1995-09-07 2001-05-27 Ф. Хоффманн-Ля Рош Аг Производные пиперидина, способ их получения, фармацевтическая композиция на их основе и промежуточные вещества
US20020151712A1 (en) * 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
WO2001032178A1 (en) * 1999-10-29 2001-05-10 Novo Nordisk A/S Use of 3,4-substituted piperidines
JP2004504319A (ja) * 2000-07-17 2004-02-12 スミスクライン　ビーチャム　パブリック　リミテッド　カンパニー ４−フェニルピペリジン誘導体の新規製造方法
EP1417174A2 (en) * 2001-08-08 2004-05-12 Neurosearch A/S Substituted amine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3912743A (en) * 1973-01-30 1975-10-14 Ferrosan As 4-Phenylpiperidine compounds
EP0152273A2 (en) * 1984-02-07 1985-08-21 A/S Ferrosan A phenylpiperidine derivative, and its salts, their preparation, compositions containing them, and their therapeutic use
EP0190496A2 (en) * 1984-12-13 1986-08-13 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
EP0266574A2 (en) * 1986-11-03 1988-05-11 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0339579A2 (en) * 1988-04-28 1989-11-02 Novo Nordisk A/S Piperidine compositions and their preparation and use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
P. PLENGE ET AL, J. PHARM. PHARMACOL., vol. 39, no. 11, 1987, pages 877 - 882, XP009022055 *
V.D. PATIL ET AL, INDIAN DRUGS, vol. 35, no. 11, 1998, pages 686 - 692, XP008079062 *

Also Published As

Publication number Publication date
WO2007072150A2 (en) 2007-06-28
TW200732304A (en) 2007-09-01
PE20071005A1 (es) 2007-10-24
AR058110A1 (es) 2008-01-23
CA2634172A1 (en) 2007-06-28
NL2000937A1 (nl) 2008-01-11
DOP2006000287A (es) 2007-11-30
GT200600516A (es) 2007-08-21
US20070142389A1 (en) 2007-06-21
WO2007072150A3 (en) 2008-05-29
EP1966137A2 (en) 2008-09-10
JP2009520018A (ja) 2009-05-21
UY30029A1 (es) 2007-07-31
NL2000937C2 (nl) 2008-07-22
NL2000376A1 (nl) 2007-06-21

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Legal Events

Date Code Title Description
AD1B A search report has been drawn up
PD2B A search report has been drawn up
V1 Lapsed because of non-payment of the annual fee

Effective date: 20100701