NL190664C - Gesubstitueerde benzhydrylpiperidinoderivaten met therapeutische werking en farmaceutische preparaten die deze verbindingen bevatten. - Google Patents

Gesubstitueerde benzhydrylpiperidinoderivaten met therapeutische werking en farmaceutische preparaten die deze verbindingen bevatten.

Info

Publication number
NL190664C
NL190664C NL8000762A NL8000762A NL190664C NL 190664 C NL190664 C NL 190664C NL 8000762 A NL8000762 A NL 8000762A NL 8000762 A NL8000762 A NL 8000762A NL 190664 C NL190664 C NL 190664C
Authority
NL
Netherlands
Prior art keywords
benzhydrylpiperidino
derivatives
substituted
compounds
pharmaceutical preparations
Prior art date
Application number
NL8000762A
Other languages
English (en)
Dutch (nl)
Other versions
NL8000762A (nl
NL190664B (nl
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of NL8000762A publication Critical patent/NL8000762A/nl
Publication of NL190664B publication Critical patent/NL190664B/xx
Application granted granted Critical
Publication of NL190664C publication Critical patent/NL190664C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NL8000762A 1979-04-10 1980-02-07 Gesubstitueerde benzhydrylpiperidinoderivaten met therapeutische werking en farmaceutische preparaten die deze verbindingen bevatten. NL190664C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/028,872 US4254130A (en) 1979-04-10 1979-04-10 Piperidine derivatives
US2887279 1979-04-10

Publications (3)

Publication Number Publication Date
NL8000762A NL8000762A (nl) 1980-10-14
NL190664B NL190664B (nl) 1994-01-17
NL190664C true NL190664C (nl) 1994-06-16

Family

ID=21845986

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8000762A NL190664C (nl) 1979-04-10 1980-02-07 Gesubstitueerde benzhydrylpiperidinoderivaten met therapeutische werking en farmaceutische preparaten die deze verbindingen bevatten.

Country Status (18)

Country Link
US (1) US4254130A (sv)
JP (1) JPS55139360A (sv)
AT (1) AT376207B (sv)
AU (1) AU536463B2 (sv)
BE (1) BE882704A (sv)
CA (1) CA1123439A (sv)
CH (1) CH648019A5 (sv)
DE (1) DE3005948A1 (sv)
DK (1) DK160250C (sv)
ES (1) ES489933A0 (sv)
FR (1) FR2453853A1 (sv)
IL (1) IL59157A (sv)
IT (1) IT1144079B (sv)
NL (1) NL190664C (sv)
NO (1) NO154964C (sv)
NZ (1) NZ192615A (sv)
SE (1) SE448727B (sv)
ZA (1) ZA80331B (sv)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231105A (en) * 1987-06-02 1993-07-27 Ajinomoto Co., Inc. Ethylamine derivatives and antihypertensives containing the same
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
JP2548800Y2 (ja) * 1991-09-13 1997-09-24 株式会社小糸製作所 自動車用ヘッドランプ
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
WO1993021156A1 (en) * 1992-04-10 1993-10-28 Merrell Dow Pharmaceuticals Inc. 4-diphenylmethyl piperidine derivatives and process for their preparation
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
DE69415319T2 (de) * 1993-06-24 1999-06-10 Albany Molecular Research, Inc., Albany, N.Y. Verfahren zur herstellung von piperidinderivaten
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
ATE230395T1 (de) 1993-06-25 2003-01-15 Merrell Pharma Inc Neue zwischenprodukte für die herstellung von antihistaminschen 4- diphenylmethyl/diphenylmethoxypiperidin-derivat n
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
CA2449419C (en) 1994-05-18 2011-09-06 Aventis Pharmaceuticals Inc. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
CN1067385C (zh) 1994-08-25 2001-06-20 默里尔药物公司 用于治疗变应性疾病的新的取代的哌啶类化合物
EP0812195B1 (en) * 1995-02-28 2002-10-30 Aventis Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol compounds
WO1996035667A1 (en) * 1995-05-08 1996-11-14 Hoescht Marion Roussel, Inc. Alpha-(substituted alkylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidine butanol derivatives, their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
IL133420A (en) * 1997-08-26 2004-07-25 Aventis Pharma Inc Tablet-shaped pharmaceutical preparation containing a combination of piperidinoalkanol and antihistamines and reduces symptomatic congestion
US6689898B2 (en) 1998-07-02 2004-02-10 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
EP1616861A3 (en) * 2004-06-15 2006-02-08 Dipharma S.p.A. A process for the preparation of keto compounds
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
ITMI20070987A1 (it) * 2007-05-16 2008-11-17 Dipharma Francis Srl Procedimento per la preparazione di composti chetonici
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
EP2289867A3 (en) 2009-08-19 2012-04-25 Jubilant Organosys Limited A process for producing 4-(4-halo-1-oxybutyl)-alpha,alpha-dimethylbenzene acetic acid or alkyl esters thereof
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
EP2371817A1 (en) 2010-04-01 2011-10-05 Arevipharma GmbH Process for the preparation of 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone and acid addition salts thereof
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
CN102659667B (zh) * 2012-04-20 2013-08-14 浙江启明药业有限公司 一种非索非那定关键中间体的合成方法
CN116375634A (zh) * 2023-01-03 2023-07-04 成都施贝康生物医药科技有限公司 卡瑞斯汀对甲苯磺酸盐的晶型和无定型

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
BE794596A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Piperidinoalcanone-oximes substituees et leur procede de preparation
ZA728544B (en) * 1972-01-28 1974-02-27 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines

Also Published As

Publication number Publication date
ES8103734A1 (es) 1981-03-16
ES489933A0 (es) 1981-03-16
JPS55139360A (en) 1980-10-31
FR2453853B1 (sv) 1982-07-09
DK160250B (da) 1991-02-18
DE3005948C2 (sv) 1989-10-05
IL59157A0 (en) 1980-05-30
IT1144079B (it) 1986-10-29
BE882704A (fr) 1980-07-31
FR2453853A1 (fr) 1980-11-07
CA1123439A (en) 1982-05-11
NO154964B (no) 1986-10-13
AU5501880A (en) 1980-10-16
CH648019A5 (de) 1985-02-28
IT8047919A0 (it) 1980-02-15
SE8002635L (sv) 1980-10-11
IL59157A (en) 1984-02-29
DK160250C (da) 1991-07-22
ATA126080A (de) 1984-03-15
NO154964C (no) 1987-01-21
NL8000762A (nl) 1980-10-14
US4254130A (en) 1981-03-03
DE3005948A1 (de) 1980-10-30
NZ192615A (en) 1982-02-23
AU536463B2 (en) 1984-05-10
NO801015L (no) 1980-10-13
SE448727B (sv) 1987-03-16
ZA80331B (en) 1981-01-28
DK133080A (da) 1980-10-11
AT376207B (de) 1984-10-25
NL190664B (nl) 1994-01-17

Similar Documents

Publication Publication Date Title
NL190664C (nl) Gesubstitueerde benzhydrylpiperidinoderivaten met therapeutische werking en farmaceutische preparaten die deze verbindingen bevatten.
NL190580C (nl) Gesubstitueerde benzhydrylpiperidinederivaten met therapeutische werking en preparaten die deze stoffen bevatten.
NO801863L (no) Farmasoeytiske preparater.
NL7810520A (nl) Nieuwe 2,6-diaminonebularinen, alsmede farmaceutische preparaten die deze verbindingen bevatten.
NL190552B (nl) 1-fenyl-4-alkyl-7,8-dialkoxy-5h-2,3-benzodiazepinederivaten en farmaceutische preparaten, die deze bevatten.
BE871584A (fr) Preparations pharmaceutiques
NL182775C (nl) Corticosteroide bevattende farmaceutische preparaten.
NL970028I1 (nl) 2(1H)-Pyridinonderivaten en farmaceutische preparaten die deze derivaten bevatten.
NL7803162A (nl) Nieuwe 1-aminoindaanderivaten, alsmede farmaceutische preparaten die deze bevatten.
NL191307C (nl) Analgetisch werkzame piperazinederivaten en farmaceutische preparaten, die deze derivaten bevatten.
NL188645C (nl) 1-azaxanthon-3-carbonzuurverbindingen en farmaceutische preparaten die deze verbindingen bevatten.
NL187397C (nl) Farmaceutische preparaten, 20,21-dinoreburnamenineverbindingen daarvoor en werkwijze voor hun bereiding.
FI824098A0 (fi) Terapeutiskt medel
NL7903769A (nl) Di-o-n-alkylglycerolderivaten en farmaceutische preparaten daarvan.
NL7801921A (nl) Farmaceutische preparaten.
NL7803448A (nl) Nieuwe benzothiadiazinederivaten, alsmede farmaceutische preparaten die deze verbindingen bevatten.
DZ276A1 (fr) Préparations pharmaceutiques.
NO883609L (no) Farmasoeytiske preparater for topisk anvendelse.
NL184896C (nl) Pyranochinolinonderivaten en gevormde farmaceutische preparaten die deze bevatten.
NL7808440A (nl) Anti-inflammatoire 1-fenylethanolamine-derivaten, far- maceutische preparaten, die deze verbindingen bevatten en werkwijzen ter bereiding daarvan.
NL7902802A (nl) Benzimidazool- en benzimidazolidine-derivaten en farmaceutische preparaten daarvan.
NL7803574A (nl) Nieuwe thenoylindaanderivaten en farmaceutische prepa- raten die deze derivaten bevatten.
NL7800667A (nl) Nieuwe dimere indool-dihydroindoolverbindingen en farmaceutische preparaten die deze verbin- dingen bevatten.
NL7614500A (nl) Montmorilloniet bevattende farmaceutische preparaten.
NL7803601A (nl) Farmaceutische preparaten.

Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
V4 Discontinued because of reaching the maximum lifetime of a patent

Free format text: 20000207