NL1026599C2 - Systeem en werkwijze voor het detecteren van ijzer in de hersenen, onder gebruikmaking van magnetische-resonantiebeeldvorming. - Google Patents
Systeem en werkwijze voor het detecteren van ijzer in de hersenen, onder gebruikmaking van magnetische-resonantiebeeldvorming. Download PDFInfo
- Publication number
- NL1026599C2 NL1026599C2 NL1026599A NL1026599A NL1026599C2 NL 1026599 C2 NL1026599 C2 NL 1026599C2 NL 1026599 A NL1026599 A NL 1026599A NL 1026599 A NL1026599 A NL 1026599A NL 1026599 C2 NL1026599 C2 NL 1026599C2
- Authority
- NL
- Netherlands
- Prior art keywords
- brain
- magnetic field
- iron
- disease
- magnetic resonance
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims description 106
- 210000004556 brain Anatomy 0.000 title claims description 54
- 229910052742 iron Inorganic materials 0.000 title claims description 52
- 238000000034 method Methods 0.000 title claims description 31
- 238000002595 magnetic resonance imaging Methods 0.000 title claims description 25
- 201000010099 disease Diseases 0.000 claims description 27
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 27
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 claims description 11
- 230000001419 dependent effect Effects 0.000 claims description 5
- 208000018737 Parkinson disease Diseases 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 claims description 4
- 230000002708 enhancing effect Effects 0.000 claims description 4
- 230000004770 neurodegeneration Effects 0.000 claims description 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 4
- 208000002593 pantothenate kinase-associated neurodegeneration Diseases 0.000 claims description 4
- 208000024827 Alzheimer disease Diseases 0.000 claims description 3
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 238000004393 prognosis Methods 0.000 claims description 2
- 230000003143 atherosclerotic effect Effects 0.000 claims 1
- 238000003384 imaging method Methods 0.000 description 16
- 238000005259 measurement Methods 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- 230000008021 deposition Effects 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 208000014644 Brain disease Diseases 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000005389 magnetism Effects 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 102000008857 Ferritin Human genes 0.000 description 2
- 108050000784 Ferritin Proteins 0.000 description 2
- 238000008416 Ferritin Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000005415 magnetization Effects 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 208000018565 Hemochromatosis Diseases 0.000 description 1
- 108010017480 Hemosiderin Proteins 0.000 description 1
- 208000033981 Hereditary haemochromatosis Diseases 0.000 description 1
- 206010065973 Iron Overload Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000002599 functional magnetic resonance imaging Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003140 lateral ventricle Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000000626 neurodegenerative effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4082—Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- High Energy & Nuclear Physics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61754303 | 2003-07-10 | ||
| US10/617,543 US20050020904A1 (en) | 2003-07-10 | 2003-07-10 | System and method for the detection of brain iron using magnetic resonance imaging |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL1026599A1 NL1026599A1 (nl) | 2005-01-11 |
| NL1026599C2 true NL1026599C2 (nl) | 2005-06-02 |
Family
ID=33564995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL1026599A NL1026599C2 (nl) | 2003-07-10 | 2004-07-07 | Systeem en werkwijze voor het detecteren van ijzer in de hersenen, onder gebruikmaking van magnetische-resonantiebeeldvorming. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20050020904A1 (enExample) |
| JP (1) | JP2005028151A (enExample) |
| DE (1) | DE102004033256A1 (enExample) |
| NL (1) | NL1026599C2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2414614T3 (es) * | 2007-01-30 | 2013-07-22 | Ge Healthcare Limited | Herramientas para ayudar en el diagnóstico de enfermedades neurodegenerativas |
| AU2012304646B2 (en) * | 2011-09-06 | 2017-02-23 | University Of Florida Research Foundation, Inc. | Systems and methods for detecting the presence of anomalous material within tissue |
| KR101685377B1 (ko) * | 2011-09-28 | 2016-12-12 | 고꾸리쯔다이가꾸호오진 구마모또 다이가꾸 | 화상해석장치, 화상해석방법 및 화상해석프로그램을 기록한 기록매체 |
| EP2709061A1 (en) * | 2012-09-12 | 2014-03-19 | Virtual Proteins B.V. | System and method for 3D visualization of brain iron deposition |
| US9157975B2 (en) * | 2012-10-24 | 2015-10-13 | Siemens Medical Solutions Usa, Inc. | Concurrent fat and iron estimation in magnetic resonance signal data |
| ES2822201T3 (es) * | 2014-06-12 | 2021-04-29 | Commissariat Energie Atomique | Método de IRM para cuantificar la cantidad de hierro en tejidos utilizando difusión por imágenes de resonancia magnética |
| AU2016240409A1 (en) * | 2015-04-02 | 2017-11-09 | Crc For Mental Health Ltd | Method for predicting risk of cognitive deterioration |
| KR102025356B1 (ko) * | 2017-11-17 | 2019-09-25 | 울산과학기술원 | 뇌에 존재하는 철의 시각화를 위한 방법 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5322682A (en) * | 1992-08-06 | 1994-06-21 | The Regents Of The University Of California | Method for quantitatively measuring and mapping stored iron in tissue using MRI |
| US6366797B1 (en) * | 1998-08-25 | 2002-04-02 | The Cleveland Clinic Foundation | Method and system for brain volume analysis |
| WO2004049939A1 (en) * | 2002-11-27 | 2004-06-17 | General Electric Company | Magnetic resonance imaging system and methods for the detection of brain iron deposits |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5603322A (en) * | 1993-01-19 | 1997-02-18 | Mcw Research Foundation | Time course MRI imaging of brain functions |
| US5617028A (en) * | 1995-03-09 | 1997-04-01 | Board Of Trustees Of The Leland Stanford Junior University | Magnetic field inhomogeneity correction in MRI using estimated linear magnetic field map |
| US5842986A (en) * | 1995-08-16 | 1998-12-01 | Proton Sciences Corp. | Ferromagnetic foreign body screening method and apparatus |
| US5860921A (en) * | 1997-04-11 | 1999-01-19 | Trustees Of The University Of Pennyslvania | Method for measuring the reversible contribution to the transverse relaxation rate in magnetic resonance imaging |
| US6385479B1 (en) * | 1999-03-31 | 2002-05-07 | Science & Technology Corporation @ Unm | Method for determining activity in the central nervous system |
| WO2000059297A2 (en) * | 1999-04-06 | 2000-10-12 | Harrington Arthritis Research Center | Methods for tracking the progression of alzheimer's disease and identifying treatments using transgenic mice |
-
2003
- 2003-07-10 US US10/617,543 patent/US20050020904A1/en not_active Abandoned
-
2004
- 2004-07-07 NL NL1026599A patent/NL1026599C2/nl not_active IP Right Cessation
- 2004-07-08 DE DE102004033256A patent/DE102004033256A1/de not_active Ceased
- 2004-07-09 JP JP2004202669A patent/JP2005028151A/ja not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5322682A (en) * | 1992-08-06 | 1994-06-21 | The Regents Of The University Of California | Method for quantitatively measuring and mapping stored iron in tissue using MRI |
| US6366797B1 (en) * | 1998-08-25 | 2002-04-02 | The Cleveland Clinic Foundation | Method and system for brain volume analysis |
| WO2004049939A1 (en) * | 2002-11-27 | 2004-06-17 | General Electric Company | Magnetic resonance imaging system and methods for the detection of brain iron deposits |
Non-Patent Citations (3)
| Title |
|---|
| ORDIDGE R J ET AL: "ASSESSMENT OF RELATIVE BRAIN IRON CONCENTRATIONS USING T2-WEIGHTED AND T2*-WEIGHTED MRI AT 3 TESLA", MAGNETIC RESONANCE IN MEDICINE, ACADEMIC PRESS, DULUTH, MN, US, vol. 32, no. 3, 1 September 1994 (1994-09-01), pages 335 - 341, XP000470229, ISSN: 0740-3194 * |
| VYMAZAL J ET AL: "DIFFERENTIATION BETWEEN HEMOSIDERIN- AND FERRITIN-BOUND BRAIN IRON USING NUCLEAR MAGNETIC RESONANCE AND MAGNETIC RESONANCE IMAGING", CELLULAR AND MOLECULAR BIOLOGY, CMB ASSOCIATIONS, NOISY-LE-GRAND, FR, vol. 46, no. 4, June 2000 (2000-06-01), pages 835 - 842, XP000986539, ISSN: 0145-5680 * |
| VYMAZAL J ET AL: "Magnetic resonance imaging of brain iron in health and disease", JOURNAL OF NEUROLOGICAL SCIENCES, ELSEVIER SCIENTIFIC PUBLISHING CO, AMSTERDAM, NL, vol. 134 (suppl), 1995, pages 19 - 26, XP002275228, ISSN: 0022-510X * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050020904A1 (en) | 2005-01-27 |
| DE102004033256A1 (de) | 2005-02-03 |
| NL1026599A1 (nl) | 2005-01-11 |
| JP2005028151A (ja) | 2005-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AD1A | A request for search or an international type search has been filed | ||
| RD2N | Patents in respect of which a decision has been taken or a report has been made (novelty report) |
Effective date: 20050331 |
|
| PD2B | A search report has been drawn up | ||
| MM | Lapsed because of non-payment of the annual fee |
Effective date: 20170801 |