NL1014354C2 - Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur. - Google Patents

Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur. Download PDF

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Publication number
NL1014354C2
NL1014354C2 NL1014354A NL1014354A NL1014354C2 NL 1014354 C2 NL1014354 C2 NL 1014354C2 NL 1014354 A NL1014354 A NL 1014354A NL 1014354 A NL1014354 A NL 1014354A NL 1014354 C2 NL1014354 C2 NL 1014354C2
Authority
NL
Netherlands
Prior art keywords
amount
phenylalanine
phenylpropanoic acid
base
bromo
Prior art date
Application number
NL1014354A
Other languages
English (en)
Dutch (nl)
Inventor
Franciscus Alphons Mari Lommen
Helmut Koller
Herbert Scherubl
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL1014354A priority Critical patent/NL1014354C2/nl
Application filed by Dsm Nv filed Critical Dsm Nv
Priority to CN01804780.7A priority patent/CN1425001A/zh
Priority to CA002399788A priority patent/CA2399788A1/en
Priority to EP01910210A priority patent/EP1272466A1/en
Priority to CZ20022710A priority patent/CZ20022710A3/cs
Priority to US10/203,698 priority patent/US20030120102A1/en
Priority to AU2001237790A priority patent/AU2001237790A1/en
Priority to HU0204456A priority patent/HUP0204456A2/hu
Priority to JP2001558416A priority patent/JP2003522756A/ja
Priority to PCT/NL2001/000078 priority patent/WO2001058865A1/en
Application granted granted Critical
Publication of NL1014354C2 publication Critical patent/NL1014354C2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NL1014354A 2000-02-11 2000-02-11 Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur. NL1014354C2 (nl)

Priority Applications (10)

Application Number Priority Date Filing Date Title
NL1014354A NL1014354C2 (nl) 2000-02-11 2000-02-11 Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur.
CA002399788A CA2399788A1 (en) 2000-02-11 2001-02-02 Method for the preparation of (s)-2-acetylthio-3-phenylpropionic acid
EP01910210A EP1272466A1 (en) 2000-02-11 2001-02-02 Method for the preparation of (s)-2-acetylthio-3-phenylpropionic acid
CZ20022710A CZ20022710A3 (cs) 2000-02-11 2001-02-02 Způsob přípravy (S)-2-acetylthio-3-fenylpropionové kyseliny
CN01804780.7A CN1425001A (zh) 2000-02-11 2001-02-02 制备(s)－2－乙酰硫－3－苯基丙酸的方法
US10/203,698 US20030120102A1 (en) 2000-02-11 2001-02-02 Method for the preparation of (s) -2-acetylthio-3-phenylpropionic acid
AU2001237790A AU2001237790A1 (en) 2000-02-11 2001-02-02 Method for the preparation of (s)-2-acetylthio-3-phenylpropionic acid
HU0204456A HUP0204456A2 (hu) 2000-02-11 2001-02-02 Eljárás (S)-2-acetil-tio-3-fenil-propionsav előállítására
JP2001558416A JP2003522756A (ja) 2000-02-11 2001-02-02 （ｓ）−２−アセチルチオ−３−フェニルプロピオン酸の製造法
PCT/NL2001/000078 WO2001058865A1 (en) 2000-02-11 2001-02-02 Method for the preparation of (s)-2-acetylthio-3-phenylpropionic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1014354A NL1014354C2 (nl) 2000-02-11 2000-02-11 Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur.
NL1014354 2000-02-11

Publications (1)

Publication Number Publication Date
NL1014354C2 true NL1014354C2 (nl) 2001-08-14

Family

ID=19770798

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1014354A NL1014354C2 (nl) 2000-02-11 2000-02-11 Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur.

Country Status (10)

Country Link
US (1) US20030120102A1 (cs)
EP (1) EP1272466A1 (cs)
JP (1) JP2003522756A (cs)
CN (1) CN1425001A (cs)
AU (1) AU2001237790A1 (cs)
CA (1) CA2399788A1 (cs)
CZ (1) CZ20022710A3 (cs)
HU (1) HUP0204456A2 (cs)
NL (1) NL1014354C2 (cs)
WO (1) WO2001058865A1 (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2227069T3 (es) 2000-03-30 2005-04-01 Ajinomoto Co., Inc. Metodo de produccion de un derivado de acido acetiltiocarboxilico aromatico.
DE10212198A1 (de) * 2002-03-19 2003-10-02 Aventis Pharma Gmbh Ethan-1-diaminium-bis(2R)-2-brom-3-phenylpropanoat), Verfahren zu dessen Herstellung und dessen Verwendung

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
WO1999042438A1 (en) * 1998-02-18 1999-08-26 Zambon Group S.P.A. Process for preparing 2-acetylthio-3-phenyl-propionic acid and the salts thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
WO1999042438A1 (en) * 1998-02-18 1999-08-26 Zambon Group S.P.A. Process for preparing 2-acetylthio-3-phenyl-propionic acid and the salts thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J.W.SKILES, ET AL.: "Angiotensin-converting enzyme inhibitors: new orally active 1,4-thiazepine-2,5-diones, 1,4-thiazine-2,5-diones, and 1,4-benzothiazepine-2,5-diones possessing antihyertensive activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 5, May 1986 (1986-05-01), American Chemical Society, Washington, DC, US, pages 784 - 796, XP002150808, ISSN: 0022-2623 *
M.-C. FOURNIE-ZALUSKI, ET AL.: "Differences in the structural requirements for selective interaction with neutral metalloendopeptidase (enkephalinase) or angiotensin-converting enzyme. Molecular investigation by use of new thiol inhibitors", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 139, no. 2, March 1984 (1984-03-01), Springer Verlag, Berlin, DE, pages 267 - 274, XP000953110, ISSN: 0014-2956 *
P. CORIC, ET AL.: "Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 6, 15 March 1996 (1996-03-15), American Chemical Society, Washington, DC, US, pages 1210 - 1219, XP002134922, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
HUP0204456A2 (hu) 2003-04-28
US20030120102A1 (en) 2003-06-26
CN1425001A (zh) 2003-06-18
JP2003522756A (ja) 2003-07-29
EP1272466A1 (en) 2003-01-08
CZ20022710A3 (cs) 2002-11-13
WO2001058865A1 (en) 2001-08-16
CA2399788A1 (en) 2001-08-16
AU2001237790A1 (en) 2001-08-20

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Effective date: 20040901