NL1014354C2 - Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur. - Google Patents

Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur. Download PDF

Info

Publication number
NL1014354C2
NL1014354C2 NL1014354A NL1014354A NL1014354C2 NL 1014354 C2 NL1014354 C2 NL 1014354C2 NL 1014354 A NL1014354 A NL 1014354A NL 1014354 A NL1014354 A NL 1014354A NL 1014354 C2 NL1014354 C2 NL 1014354C2
Authority
NL
Netherlands
Prior art keywords
amount
phenylalanine
phenylpropanoic acid
base
bromo
Prior art date
Application number
NL1014354A
Other languages
English (en)
Dutch (nl)
Inventor
Franciscus Alphons Mari Lommen
Helmut Koller
Herbert Scherubl
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL1014354A priority Critical patent/NL1014354C2/nl
Application filed by Dsm Nv filed Critical Dsm Nv
Priority to PCT/NL2001/000078 priority patent/WO2001058865A1/en
Priority to JP2001558416A priority patent/JP2003522756A/ja
Priority to EP01910210A priority patent/EP1272466A1/en
Priority to US10/203,698 priority patent/US20030120102A1/en
Priority to AU2001237790A priority patent/AU2001237790A1/en
Priority to CZ20022710A priority patent/CZ20022710A3/cs
Priority to HU0204456A priority patent/HUP0204456A2/hu
Priority to CN01804780.7A priority patent/CN1425001A/zh
Priority to CA002399788A priority patent/CA2399788A1/en
Application granted granted Critical
Publication of NL1014354C2 publication Critical patent/NL1014354C2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NL1014354A 2000-02-11 2000-02-11 Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur. NL1014354C2 (nl)

Priority Applications (10)

Application Number Priority Date Filing Date Title
NL1014354A NL1014354C2 (nl) 2000-02-11 2000-02-11 Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur.
JP2001558416A JP2003522756A (ja) 2000-02-11 2001-02-02 （ｓ）−２−アセチルチオ−３−フェニルプロピオン酸の製造法
EP01910210A EP1272466A1 (en) 2000-02-11 2001-02-02 Method for the preparation of (s)-2-acetylthio-3-phenylpropionic acid
US10/203,698 US20030120102A1 (en) 2000-02-11 2001-02-02 Method for the preparation of (s) -2-acetylthio-3-phenylpropionic acid
PCT/NL2001/000078 WO2001058865A1 (en) 2000-02-11 2001-02-02 Method for the preparation of (s)-2-acetylthio-3-phenylpropionic acid
AU2001237790A AU2001237790A1 (en) 2000-02-11 2001-02-02 Method for the preparation of (s)-2-acetylthio-3-phenylpropionic acid
CZ20022710A CZ20022710A3 (cs) 2000-02-11 2001-02-02 Způsob přípravy (S)-2-acetylthio-3-fenylpropionové kyseliny
HU0204456A HUP0204456A2 (hu) 2000-02-11 2001-02-02 Eljárás (S)-2-acetil-tio-3-fenil-propionsav előállítására
CN01804780.7A CN1425001A (zh) 2000-02-11 2001-02-02 制备(s)－2－乙酰硫－3－苯基丙酸的方法
CA002399788A CA2399788A1 (en) 2000-02-11 2001-02-02 Method for the preparation of (s)-2-acetylthio-3-phenylpropionic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1014354A NL1014354C2 (nl) 2000-02-11 2000-02-11 Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur.
NL1014354 2000-02-11

Publications (1)

Publication Number Publication Date
NL1014354C2 true NL1014354C2 (nl) 2001-08-14

Family

ID=19770798

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1014354A NL1014354C2 (nl) 2000-02-11 2000-02-11 Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur.

Country Status (10)

Country Link
US (1) US20030120102A1 (cs)
EP (1) EP1272466A1 (cs)
JP (1) JP2003522756A (cs)
CN (1) CN1425001A (cs)
AU (1) AU2001237790A1 (cs)
CA (1) CA2399788A1 (cs)
CZ (1) CZ20022710A3 (cs)
HU (1) HUP0204456A2 (cs)
NL (1) NL1014354C2 (cs)
WO (1) WO2001058865A1 (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE275129T1 (de) 2000-03-30 2004-09-15 Ajinomoto Kk Verfahren zur herstellung von aromatischen acylthiocarbonsäurederivaten
DE10212198A1 (de) * 2002-03-19 2003-10-02 Aventis Pharma Gmbh Ethan-1-diaminium-bis(2R)-2-brom-3-phenylpropanoat), Verfahren zu dessen Herstellung und dessen Verwendung

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
WO1999042438A1 (en) * 1998-02-18 1999-08-26 Zambon Group S.P.A. Process for preparing 2-acetylthio-3-phenyl-propionic acid and the salts thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
WO1999042438A1 (en) * 1998-02-18 1999-08-26 Zambon Group S.P.A. Process for preparing 2-acetylthio-3-phenyl-propionic acid and the salts thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J.W.SKILES, ET AL.: "Angiotensin-converting enzyme inhibitors: new orally active 1,4-thiazepine-2,5-diones, 1,4-thiazine-2,5-diones, and 1,4-benzothiazepine-2,5-diones possessing antihyertensive activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 5, May 1986 (1986-05-01), American Chemical Society, Washington, DC, US, pages 784 - 796, XP002150808, ISSN: 0022-2623 *
M.-C. FOURNIE-ZALUSKI, ET AL.: "Differences in the structural requirements for selective interaction with neutral metalloendopeptidase (enkephalinase) or angiotensin-converting enzyme. Molecular investigation by use of new thiol inhibitors", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 139, no. 2, March 1984 (1984-03-01), Springer Verlag, Berlin, DE, pages 267 - 274, XP000953110, ISSN: 0014-2956 *
P. CORIC, ET AL.: "Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 6, 15 March 1996 (1996-03-15), American Chemical Society, Washington, DC, US, pages 1210 - 1219, XP002134922, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
CZ20022710A3 (cs) 2002-11-13
JP2003522756A (ja) 2003-07-29
CN1425001A (zh) 2003-06-18
HUP0204456A2 (hu) 2003-04-28
CA2399788A1 (en) 2001-08-16
AU2001237790A1 (en) 2001-08-20
US20030120102A1 (en) 2003-06-26
WO2001058865A1 (en) 2001-08-16
EP1272466A1 (en) 2003-01-08

Similar Documents

Publication Publication Date Title
KR102065543B1 (ko) 메틸 4-아미노-3-클로로-6-(4-클로로-2-플루오로-3-메톡시페닐)피리딘-2-카르복실레이트의 제조 방법
NL1014354C2 (nl) Werkwijze voor de bereiding van (S) -2-acethylthio-3-fenylpropaanzuur.
Hajipour et al. Synthesis of aryl azides from aryl halides promoted by Cu2O/tetraethylammonium prolinate
KR20130125368A (ko) 락틱산-아민 복합체의 제조 방법
Hepperle et al. Mono N-arylation of piperazine (III): metal-catalyzed N-arylation and its application to the novel preparations of the antifungal posaconazole and its advanced intermediate
KR102065950B1 (ko) (4-클로로-2-플루오로-3-치환된-페닐) 보로네이트의 단리 방법 및 그의 사용 방법
KR20080007347A (ko) 오염화인과 디엠에프로부터 부산물로서 옥시염화인의 생성및 빌스마이어-헥크 시약으로의 변환에 의한 염소화 반응에사용되는 옥시염화인의 용도
CN105154070B (zh) 基于光点击反应且具有荧光响应的dna标记物及制备方法与应用
NL1014353C2 (nl) Werkwijze voor de bereiding van (R) -2-broom-3-fenylpropaanzuur.
CN102127093B (zh) 头孢替安酯盐酸盐的精制工艺
CA1236118A (en) Ethoxylated lignite composition and method of preparing
JP3932755B2 (ja) ２−ヒドロキシ−４−メチルチオブタン酸の製造方法
CN103073606A (zh) 5’-s-(4,4’-二甲氧基三苯甲基)-2’-脱氧肌苷的合成与制备方法
US4433151A (en) Oxy benzoic acid terminated polyether derivatives of 8-hydroxy quinolines
CN114539085A (zh) 一种脲基衍生物的制备
CN111574463A (zh) 一种利格列汀中间体化合物ⅳ
WO2014096870A1 (en) Process for producing lactic acid
TWI825164B (zh) 製備氟烷基腈的方法及其在製備相關氟烷基四唑中的用途
JPS6161844B2 (cs)
CN1032857C (zh) 新的双烯酮亚胺衍生物的制备方法
CN100390190C (zh) D-葡萄糖醛酸的制备方法
JP4553419B2 (ja) アダマンタンジオ−ル類の製造方法
US20240092787A1 (en) Pharmaceutical process and intermediates
CN116854735A (zh) 一种泰诺福韦的合成方法
SU682524A1 (ru) Способ получени натриевой соли железного комплекса оксиэтилиден дифосфоновой кислоты

Legal Events

Date Code Title Description
PD2B A search report has been drawn up
VD1 Lapsed due to non-payment of the annual fee

Effective date: 20040901