NI201500074A - Trans-4-{2-[4-(2, 3-diclorofenil)-piperazin-1-il]-etil}-n, n-dimetilcarbamoil-ciclohexilamina para el tratamiento de síntomas negativos de la esquizofrenia. - Google Patents
Trans-4-{2-[4-(2, 3-diclorofenil)-piperazin-1-il]-etil}-n, n-dimetilcarbamoil-ciclohexilamina para el tratamiento de síntomas negativos de la esquizofrenia.Info
- Publication number
- NI201500074A NI201500074A NI201500074A NI201500074A NI201500074A NI 201500074 A NI201500074 A NI 201500074A NI 201500074 A NI201500074 A NI 201500074A NI 201500074 A NI201500074 A NI 201500074A NI 201500074 A NI201500074 A NI 201500074A
- Authority
- NI
- Nicaragua
- Prior art keywords
- schizophrenia
- negative symptoms
- dimethylcarbamoyl
- cyclohexylamine
- piperazin
- Prior art date
Links
- 201000000980 schizophrenia Diseases 0.000 title abstract 3
- -1 2, 3-DICHLOROPHENYL Chemical class 0.000 title 1
- PZWXYRDNQYUIIU-UHFFFAOYSA-N 3-cyclohexyl-1,1-dimethylurea Chemical compound CN(C)C(=O)NC1CCCCC1 PZWXYRDNQYUIIU-UHFFFAOYSA-N 0.000 title 1
- 208000024891 symptom Diseases 0.000 abstract 2
- KPWSJANDNDDRMB-QAQDUYKDSA-N cariprazine Chemical compound C1C[C@@H](NC(=O)N(C)C)CC[C@@H]1CCN1CCN(C=2C(=C(Cl)C=CC=2)Cl)CC1 KPWSJANDNDDRMB-QAQDUYKDSA-N 0.000 abstract 1
- 229960005123 cariprazine Drugs 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a trans-4-{2-[4-(2, 3-diclorofenil)-piperazin-1-il]-etil}-N, N-dimetilcarbamoil-ciclohexilamina (cariprazina) y a sus sales farmacéuticamente aceptables, hidratos, solvatos y polimorfos para su uso en el tratamiento de síntomas negativos primarios de la esquizofrenia y/o síntomas predominantemente negativos de la esquizofrenia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1200691A HU231227B1 (hu) | 2012-11-29 | 2012-11-29 | Transz-4-{2-[4-(2,3-diklórfenil)-piperazin-1-il]-etil}N,N-dimetilkarbamoil-ciklohexilamin skizofrénia negatív tüneteinek kezelésére |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NI201500074A true NI201500074A (es) | 2015-09-18 |
Family
ID=70289034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NI201500074A NI201500074A (es) | 2012-11-29 | 2015-05-27 | Trans-4-{2-[4-(2, 3-diclorofenil)-piperazin-1-il]-etil}-n, n-dimetilcarbamoil-ciclohexilamina para el tratamiento de síntomas negativos de la esquizofrenia. |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US20150306094A1 (es) |
| EP (2) | EP2925324B1 (es) |
| JP (2) | JP2016501215A (es) |
| KR (2) | KR20210010955A (es) |
| CN (1) | CN104812390A (es) |
| AP (1) | AP2015008448A0 (es) |
| AU (1) | AU2013350819B9 (es) |
| BR (1) | BR112015012512A2 (es) |
| CA (1) | CA2890952A1 (es) |
| CL (1) | CL2015001468A1 (es) |
| CR (1) | CR20150244A (es) |
| CY (1) | CY1123766T1 (es) |
| DK (1) | DK2925324T3 (es) |
| EA (1) | EA039245B1 (es) |
| ES (1) | ES2863052T3 (es) |
| GE (1) | GEP20186849B (es) |
| HK (1) | HK1212608A1 (es) |
| HR (1) | HRP20210486T1 (es) |
| HU (2) | HU231227B1 (es) |
| IL (1) | IL238723B (es) |
| LT (1) | LT2925324T (es) |
| MD (2) | MD4865C1 (es) |
| MX (2) | MX2015006677A (es) |
| MY (1) | MY174663A (es) |
| NI (1) | NI201500074A (es) |
| NZ (1) | NZ708295A (es) |
| PE (1) | PE20151052A1 (es) |
| PH (1) | PH12015501124B1 (es) |
| PL (1) | PL2925324T3 (es) |
| PT (1) | PT2925324T (es) |
| RS (1) | RS61509B1 (es) |
| SG (1) | SG11201503672SA (es) |
| SI (1) | SI2925324T1 (es) |
| UA (1) | UA123492C2 (es) |
| WO (1) | WO2014083522A1 (es) |
| ZA (1) | ZA201503660B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG192507A1 (en) | 2008-07-16 | 2013-08-30 | Richter Gedeon Nyrt | Pharmaceutical formulations containing dopamine receptor ligands |
| CN105218484B (zh) * | 2015-09-14 | 2018-02-23 | 安徽省逸欣铭医药科技有限公司 | 酒石酸卡利拉嗪及其制备方法和医药用途 |
| HU231173B1 (hu) * | 2016-07-08 | 2021-06-28 | Richter Gedeon Nyrt. | Ipari eljárás cariprazine előállítására |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| WO2019016828A1 (en) * | 2017-07-15 | 2019-01-24 | Msn Laboratories Private Limited, R&D Center | NOVEL PROCESSES FOR THE PREPARATION OF TRANS-N- {4- [2- [4- (2,3-DICHLOROPHENYL) PIPERAZIN-1-YL] ETHYL] CYCLOHEXYL} -N ', N'-DIMETHYLUMED HYDROCHLORIDE AND POLYMORPHS THIS ONE |
| US20200375983A1 (en) * | 2017-12-01 | 2020-12-03 | Aurobindo Pharma Ltd | A process for the preparation of cariprazine hydrochloride |
| WO2020056929A1 (zh) * | 2018-09-21 | 2020-03-26 | 上海诚妙医药科技有限公司 | 卡利拉嗪盐酸盐的新晶型及其制备方法及其用途 |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
| US11344503B2 (en) | 2019-12-13 | 2022-05-31 | Halo Science LLC | Cariprazine release formulations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227534B1 (en) | 2003-08-04 | 2011-08-29 | Richter Gedeon Nyrt | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
| HU230748B1 (hu) | 2007-05-11 | 2018-02-28 | Richter Gedeon Nyrt | Új piperazin só és előállítási eljárása |
| HUP0700369A2 (en) | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia |
| KR20100022955A (ko) * | 2007-05-24 | 2010-03-03 | 리히터 게데온 닐트. | (티오) -카르바모일-시클로헥산 유도체 및 정신분열 치료 방법 |
| WO2010126527A1 (en) | 2009-05-01 | 2010-11-04 | Forest Laboratories Holdings Limited | Methods of treating cns disorders |
-
2012
- 2012-11-29 HU HU1200691A patent/HU231227B1/hu unknown
-
2013
- 2013-11-28 KR KR1020217001911A patent/KR20210010955A/ko not_active Application Discontinuation
- 2013-11-28 KR KR1020157015259A patent/KR102314248B1/ko active IP Right Grant
- 2013-11-28 LT LTEP13805597.5T patent/LT2925324T/lt unknown
- 2013-11-28 EA EA201500575A patent/EA039245B1/ru unknown
- 2013-11-28 MD MDA20150058A patent/MD4865C1/ro active IP Right Grant
- 2013-11-28 SG SG11201503672SA patent/SG11201503672SA/en unknown
- 2013-11-28 GE GEAP201313870A patent/GEP20186849B/en unknown
- 2013-11-28 DK DK13805597.5T patent/DK2925324T3/da active
- 2013-11-28 RS RS20210242A patent/RS61509B1/sr unknown
- 2013-11-28 EP EP13805597.5A patent/EP2925324B1/en active Active
- 2013-11-28 JP JP2015544593A patent/JP2016501215A/ja active Pending
- 2013-11-28 AU AU2013350819A patent/AU2013350819B9/en active Active
- 2013-11-28 WO PCT/IB2013/060465 patent/WO2014083522A1/en active Application Filing
- 2013-11-28 US US14/646,226 patent/US20150306094A1/en not_active Abandoned
- 2013-11-28 SI SI201331846T patent/SI2925324T1/sl unknown
- 2013-11-28 MD MDA20200089A patent/MD20200089A2/ro unknown
- 2013-11-28 NZ NZ708295A patent/NZ708295A/en active IP Right Revival
- 2013-11-28 AP AP2015008448A patent/AP2015008448A0/xx unknown
- 2013-11-28 MX MX2015006677A patent/MX2015006677A/es unknown
- 2013-11-28 PT PT138055975T patent/PT2925324T/pt unknown
- 2013-11-28 ES ES13805597T patent/ES2863052T3/es active Active
- 2013-11-28 BR BR112015012512A patent/BR112015012512A2/pt not_active Application Discontinuation
- 2013-11-28 CN CN201380062030.9A patent/CN104812390A/zh active Pending
- 2013-11-28 CA CA2890952A patent/CA2890952A1/en not_active Abandoned
- 2013-11-28 HU HUE13805597A patent/HUE054054T2/hu unknown
- 2013-11-28 MY MYPI2015001236A patent/MY174663A/en unknown
- 2013-11-28 EP EP19213168.8A patent/EP3653211A1/en active Pending
- 2013-11-28 PE PE2015000702A patent/PE20151052A1/es not_active Application Discontinuation
- 2013-11-28 PL PL13805597T patent/PL2925324T3/pl unknown
- 2013-11-28 UA UAA201506218A patent/UA123492C2/uk unknown
-
2015
- 2015-05-10 IL IL238723A patent/IL238723B/en active IP Right Grant
- 2015-05-11 CR CR20150244A patent/CR20150244A/es unknown
- 2015-05-20 PH PH12015501124A patent/PH12015501124B1/en unknown
- 2015-05-22 ZA ZA2015/03660A patent/ZA201503660B/en unknown
- 2015-05-27 MX MX2021000342A patent/MX2021000342A/es unknown
- 2015-05-27 NI NI201500074A patent/NI201500074A/es unknown
- 2015-05-29 CL CL2015001468A patent/CL2015001468A1/es unknown
-
2016
- 2016-01-19 HK HK16100562.0A patent/HK1212608A1/zh unknown
-
2019
- 2019-03-07 JP JP2019042062A patent/JP2019163240A/ja active Pending
-
2021
- 2021-02-03 CY CY20211100087T patent/CY1123766T1/el unknown
- 2021-03-25 HR HRP20210486TT patent/HRP20210486T1/hr unknown
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