MXPA97007900A - Sanitation composition especially adapted for the treatment of buildings for animal crises - Google Patents

Abstract

The present invention relates to: A disinfectant composition in aqueous solution specially adapted for the treatment of buildings for the rearing of animals, characterized in that it contains, in weight proportions, between 1 and 20% of monoaldehydes or dialdehydes, especially glutaraldehyde, between 3 and 35% of salts, especially quaternary ammonium chlorides, between 1 and 15% of ethoxylated fatty alcohol, and between 0.5 and 15% of an insecticide agent chosen among the pyrethrinoids of

Description

COMPOSITION DISINFECTANT SPECIALLY ADAPTED FOR THE TREATMENT OF BUILDINGS FOR ANIMAL FARMING The present invention relates to a disinfectant composition in aqueous solution specially adapted for the treatment of buildings for animal husbandry during the so-called periods of "sanitary vacuum" that separate each batch of animals. Currently on the market are numerous disinfectant compositions whose purpose is the cleaning of the premises in the case of the industrial breeding of animals. To give satiety, such compositions must have a remarkable disinfectant activity, that is, a bactericidal, virucidal and fungicidal action; in addition, they must be chemodegradable or biodegradable, and not be toxic and not very corrosive. In order to satisfy these different criteria, it has already been proposed, in accordance with publication FR-A-87 15 212, a composition containing, by weight, between 3 and 35% of quaternary ammonium salts, between 1 and 20% of straight chain di aldehyde, especially glutaraldehyde, and between 1 and 15% of ethoxy side fatty alcohols. This composition, in use, has proved to be particularly active, easily eli unleable and without danger to human health. The bactericidal, virucidal and fungicidal qualities of quaternary ammonium and glutaraldehyde are well known for a long time. In the aforementioned disinfected composition, the fatty alcohols act as wetting and solubilizing agents capable of improving the "stability" of the solution and allowing the increase in the proportion of active products. The combination of quaternary ammonium salts of glutaraldehyde and ethoxylated fatty alcohols therefore makes it possible to obtain, in aqueous solution, very concentrated disinfectant compositions with a very broad spectrum of disinfectant activity and having, in particular, a very remarkable directed activity due to the excellent Tenoactivity of quaternary ammoniums. By way of example, the following composition proved to be particularly active: dideei chloride ldimeti lamonium 18.75 g Dioctyl chloride ldimeti lamonium 18.75 g Chloride of oct i ldeci Idi eti lamonio 37.50 g Alkyl Chloride < C14 50% - C12 40% - C16 10%) dimet i 1ben i 1 ammonium 50 g Glutaraldehldo 62.50 g Terpinol 20 g Pine essence 20 g Fatty alcohols ethoxylated with 10 moles of ethylene oxide and 90% active matters. 40 g Angelic Green Dye < E 131 + E 104) 1 g Water q .s .p. 1 1 i tro Despite its proven advantages, this disinfectant composition has the drawback of not having any insecticidal action and therefore must be combined with a complementary treatment with the help of an insecticide product to obtain a complete sanitary "action". These operations represent an economic and material effort (number of operations, exposure of personnel, lengthening of period of "sanitary vacuum" of animal breeding sites). Therefore, and despite manufacturers' recommendations, users are sometimes tempted to mix in the course of the same treatment disinfectant specialties that do not have insecticidal action and insecticidal specialties that have no bactericidal or virucidal action. The mixtures made in this way, however, contact substances which are not necessarily compatible with each other and can cause poisoning-type accidents. In addition, studies that allow manufacturers to determine the efficacy of their product do not systematically take into account interactions that may appear when these products are associated with another specialty and can not guarantee that products mixed in this way retain their activity and stability. . Therefore, it would be desirable to be able to have a polyvalent specialty effectively associating disinfectant properties (bactericides, viricides and fungicides) and insecticidal properties. In spite of this obvious need, up to now it had not been possible to collect the necessary active substances in an active form, which is iscible in water and in suitable concentrations to obtain the essential efficacy for a single dose of use. The object of the present invention is to satisfy this need by proposing a composition adapted to the treatment of animal breeding buildings, chemically stable which has a high efficacy both insecticidal and bactericidal, virucidal and fungicidal and in parallel non-toxic for the intended use. and slightly corrosive in relation to exposed materials (especially metals). According to the present invention, this composition is characterized in that it contains, in proportions by weight, between 1 and 20% of onoaldehydes or dialdehydes, especially glutaraldehyde, between 3 and 35% of salts, especially quaternary ammonium chlorides, between 1 and 15 % of ethoxylated fatty alcohol and between 0.5 and 15% of an insecticide agent chosen among the synthetic pyrethrinoids, ie the analogs of pyrethrin which is a known insecticide itself constituted by toxic principles extracted from flowers and aerial parts of pi retre (Chrysanthemum Cineraria Folium). We observed that, surprisingly, it was possible, from the aforementioned known disinfectant composition, object of document FR-A-87 15 212 and acting on the nature and proportions of the solvents and surfactants employed, to obtain a stable and effective polyvalent composition thanks to the incorporation of a specific insecticide agent. According to the present invention, this insecticidal agent can advantageously be constituted by an isomer or a mixture of isomers of permethrin, particularly a mixture of approximately 25% cis isomer and about 75% trans isomer. Permethrin or <; l, RS) cis, trans (dichloro-2,2 vinyl) -3 dimethyl-2,2-cyclopropane carboxylate of phenoxy-3 benzyl is a pyrethrinoid with a broad spectrum of activity that is distinguished by a good persistence and whose effectiveness allows ensure insecticidal protection when used in low doses. The composition according to the present invention can advantageously contain about 20 g of synthetic pyrethrinoids and especially of permethrin by solution sol. According to another feature of the invention, the composition contains between 0.2 and 40% of terpene extacto and especially terpinol. The addition of terpinol in the composition according to the present invention is especially advantageous taking into consideration the fact that this compound, which has important bactericidal qualities, is at the same time perfume. By way of example, 100 g of terpinol per liter of solution can be used. According to another feature of the present invention, the composition contains essentially, per liter of solution, 60 g of ethoxylated fatty alcohols, consisting of ethoxylated compounds with 11 moles of ethyl alcohol and 45% of active substance. These fatty alcohols function as wetting and solubilizing agents. It is also possible, advantageously, to use, as quaternary ammonium salts, salts largely similar to those contained in the aforementioned disinfectant composition of document FR-A-87 15 212, that is, dialkyl ethylammonium chlorides and / or chlorides of alq? ilbencildi eti lamonio whose alkyl radicals contain between 8 and 16 carbon atoms. According to another characteristic of the invention, the composition essentially contains, per liter of solution, 125 g of quaternary ammonium salts constituted by a mixture of didecyl chloride, imidemmonium chloride, dioctyldimethyl ammonium chloride, octyl chloride, and the like. The Idimet and the anion and chlorides of alkyldimethylbenzylammonium, the latter being constituted by a mixture of approximately 50% by weight of C14 compounds, 40% by weight of C12 compounds and 10% by weight of C16 compounds. According to another feature of the present invention, the composition contains essentially 62.5 g of glutaraldehyde per liter of solution. The composition according to the present invention can and may contain other additives, such as a dye, especially a green dye. By way of example, the following composition proved to be especially advantageous, in uses dideci ldimeti lamonium chloride 18.75 g Dioctyl dimethyl ammonium chloride 18.75 g Chloride of octi ldeci ldimeti lamonio 37.50 g Alkydimether Chloride Ibencylammonium (C14 alkyl 50% -C12 40% - C16 10%) 50 g Blutaraldehyde 62.50 g Permethrin (cis / trans isomer: 25% / 75%) 20 g Ethoxylated fatty alcohols with 11 moles of ethylene oxide and 45% of active substances. 60 g Terpinol 100 g Angelic green coloring (E131 - E104) 0.020 g Water de ineral ized q.s.p. 1 liter The properties of the composition object of the present invention could be verified by the experimental tests described below: 1) INSECTICIDE EFFICACY Two tests were carried out in order to evaluate the insecticidal power of the composition in accordance with the > present invention. The performance of such tests proved to be indispensable, taking into consideration the fact that if the insecticidal properties of the pyrethrinoids are well known per se, it was not evident that, within the composition, no antagonists could be produced or "entrapment" phenomenon. of active matters by the other constituents. a) Laboratory test This test was carried out in accordance with the "Protocole exp rimental destiné á établir, en laboratoire, l'efficacité d'une spécialité insecticide" (Experimental protocol whose purpose is to establish, in the laboratory, the efficacy of a specialty insecticide) (Center National d'Etudes Vétérinai res et Al imentai res) (National Center for Veterinary and Food Studies) and made it possible to verify the efficacy of a composition with the composition according to the present invention on surfaces of a different nature (wood, cement and metal). The results, which take into consideration mortality percentages obtained with flies, appear in figure la (corresponding to mortality without treatment) and in figure Ib (corresponding to mortality after treatment).

From the first 20 minutes of exposure, the efficacy is optimal. b) Tests carried out in the field Only the natural conditions of use make it possible to evaluate the actual effectiveness of an insecticide. In fact, the remanence of the treatment is an important quality criterion for this type of product. This remanence is influenced by the stability and resistance of the insecticide on the surfaces to the extent that the latter acts by contact with the insect. The contact with the insect is in turn influenced by the natural fouling of the buildings dedicated to the cria. of animals with the passage of time. The test was carried out in accordance with method No. 107: "Methodological approach for the processing of insecticide products destined to lutter against the mouches des étables dans les lacaux d'élevages d'animaux domestiques" (Test method for practical effectiveness of insecticide products whose purpose is to fight against flies in stables in breeding premises of domestic animals) established by the members of the Coission des Essais Biologiques de l'Association Nationale pour la Protection des Plantes (Commission for Biological Tests) of the National Association for the Protection of Plants). Held the summer, the trial consisted in the comparison of the variations of the population of flies in the buildings dedicated to the breeding of animals in the course of the 3 months after the treatment. The test was carried out both in an untreated building and in a building treated by the composition in accordance with the present invention and in a building treated with a known insecticide for positive control. The results obtained appear in figure 2. CONCLUSION: These results show that the composition according to the present invention is equally effective as a product known exclusively as an insecticide. 2) BACTERICIDE AND VIRICIDE EFFICACY a) Bactericide Preliminary tests allowed to verify that the substances active responsible for bactericidal activity retain their potency. The synergistic association of the mixture of aqueous ammonia and aldehyde which is a characteristic of the above disinfectant composition according to the document FP-A-87 15 212 is not inhibited within the framework of the composition according to the present invention. . This control was carried out by comparing the CMB (minimum bactericidal concentrations) obtained in the Pseudomonas aeruginosa strain in the presence of pure water at 30 ° C (method: by icroplates in accordance with AFNOR NF T 72-170). Four variants of the composition according to the present invention were tested (variations in the proportions of surfactants and co-solvents). RESULTS: For each trial (including the previous disinfectant composition), Bactericidal Minimum Concentrations were obtained for dilutions less than or equal to 0.125%. CONCLUSION: Bactericidal efficacy is maintained compared to the previous approved disinfectant composition for use at 0.5% dilution on e to Pseudomas aeruginosa; the use of the composition according to the present invention is foreseen for a dilution of 2%. b) VIRICIDAL The test was carried out by micromanagement on the virus of the disease of Talfan (Picornaevirus type 1), well known for its resistance to disinfectants and which constitutes for this reason the factor limiting the dilution of use. RESULTS: The composition according to the present invention, diluted at 2%, allows to obtain a reduction of at least 3 Log of the viral titer, in accordance with the requirements of the Laboratoire des Medicamente Vétérinaires (Laboratory of Veterinary Drugs) in relation to the disinfectant of agricultural use. 3) CHEMICAL STABILITY The stability study of the composition includes the control of the appearance of the product, the measurement of the pH and the dosage of the active substances. The study is carried out on samples stored in polypropylene bottles, in a bath at a temperature of 37 ° C, in order to have an accelerated aging profile. The data presented below correspond to batches stored at 37 ° C for more than 3 months, a) Appearance of the samples absence of precipitates absence of phase separation of the constituents stable coloration.

That is, an aspect without change after 3 months at 37 ° C. b) Stability of the aldehydes The stability at a temperature of 37 ° C of the aldehydes is shown in Figure 3. No significant degradation is observed after 99 days at a temperature of 37 ° C. c) Stability of quaternary ammoniums The stability at 37 ° C of quaternary ammonium is shown in Figure 4. No significant degradation is observed after 99 days at a temperature of 37 ° C. d) Stability of permethrin The stability at 37 ° C of permethrin appears in Figure 5. No significant degradation is observed after 99 days at a temperature of 37 ° C. e) Variations of the pH The pH evolution at a temperature of 37 * C appears in figure 6. The pH decreases slightly after 2 months f) Comments The graphs mentioned above correspond to the results of the dosages made on six different batches of the composition according to the present invention. These lots contain some variations among them in terms of the percentages of excipients. It can be seen that the active substances successfully resist the aging conditions at 37 ° C for at least 3 months. 4) TOXICOLOGICAL ASPECT The different constituents of the composition according to the present invention do not present a particular danger in the expected dose of use (2% in aqueous dilution). 5) CORROSIVE ACTION OF THE COMPOSITION In the doses of use, the composition presents no particular risk in relation to the materials exposed to the treatments.

Claims (11)

1. CLAIMS 1. The use for the treatment of buildings for the rearing of animals, particularly during the periods known as "sanitary vacuum" that separate each batch of animals, from a disinfectant composition in aqueous solution containing, in proportions by weight, between 1 and 20% of onoaldehydes or dialdehldoß, especially glutaraldehyde, between 3 and 35% of salts, especially quaternary ammonium chlorides, between 1 and 15% of ethoxylated fatty alcohols, and between 0.5 and 15% of an insecticide agent chosen among the pyrethrinoids of synthesis.
2. 2. The use according to claim 1, characterized in that the insecticidal agent constitutes an isomer or a mixture of isomers of permethrin.
3. 3. The use according to claim 2, characterized in that the insecticidal agent contains approximately 25% cis isomer and 75% trans isomer.
4. 4. The use according to any of the rei indications 1 to 3, characterized in that it contains between 0.2 and 40% terpene extract, especially terpinal.
5. 5. The use according to any of claims 1 to 4, characterized in that the quaternary ammonium salts are dialkydimetiimmonium chlorides and / or alkylimethylbenzylchlorides, the alkyl radicals contain between 8 and 16 carbon atoms. .
6. 6. The use according to claim 5, characterized in that it contains essentially, per liter of solution, 125 g of quaternary ammonium salt constituted by a mixture of d idee and Idimet chloride, of dioctyldimethylammonium chloride, of octylchloride chloride. Idimet and ammonium chlorides and Ibenci lamanium alkyl chlorides, the latter consisting of a mixture of approximately 50% by weight of C14 compounds, 40% by weight of C12 compounds and 10% by weight of C16 compounds. The use according to any of claims 1 to 6, characterized in that it contains essentially 62.5 g of glutaraldehyde per liter of solution. 8. The use according to any of claims 1 to 7, characterized in that it contains essentially 20 g of synthetic pyrethrinoids and especially of permethrin per liter of solution. 9. The use according to any of the above indications 1 to 8, characterized in that it contains essentially, per liter of solution, 60 g of ethazylated fatty alcohols, constituted by ethoxylated compounds with 11 moles of ethyl alcohol and 45% of active substance. 10. The use according to any of claims 1 to 9, characterized in that it contains essentially 100 g of terpinol per liter of solution. 11. The disinfectant composition in aqueous solution specially adapted for the treatment of buildings for the breeding of animals, characterized because it contains in weight proportions between 1 and 20% of onoaldehydes to good dialdehydes, especially glutaraldehyde, between 3 and 35% of dialki chlorides. limeti lamonia and / or alkylbenzyl chlorides Idimethylammonium, the alkyl radicals contain between 8 and 16 carbon atoms, between 1 and 15% of ethoxylated fatty alcohols consisting of ethoxylated compounds with 11 moles of ethylene oxide and 45% of active substance, and between 0.5 and 15% of an insecticide agent chosen among the synthetic pyrethrinoids, this composition is free of salts of aliphatic acids or aromatic hydroxylates.