MXPA06011021A - Compuestos de imidazol. - Google Patents
Compuestos de imidazol.Info
- Publication number
- MXPA06011021A MXPA06011021A MXPA06011021A MXPA06011021A MXPA06011021A MX PA06011021 A MXPA06011021 A MX PA06011021A MX PA06011021 A MXPA06011021 A MX PA06011021A MX PA06011021 A MXPA06011021 A MX PA06011021A MX PA06011021 A MXPA06011021 A MX PA06011021A
- Authority
- MX
- Mexico
- Prior art keywords
- methyl
- phenyl
- imidazol
- chloro
- compounds according
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract description 3
- 238000000034 method Methods 0.000 claims abstract description 98
- 239000000203 mixture Substances 0.000 claims abstract description 68
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- 210000000265 leukocyte Anatomy 0.000 claims abstract description 52
- 230000001404 mediated effect Effects 0.000 claims abstract description 37
- 206010061218 Inflammation Diseases 0.000 claims abstract description 27
- 230000004054 inflammatory process Effects 0.000 claims abstract description 27
- 150000001875 compounds Chemical class 0.000 claims description 270
- -1 hydroxy, amino Chemical group 0.000 claims description 152
- 125000001424 substituent group Chemical group 0.000 claims description 74
- 239000008194 pharmaceutical composition Substances 0.000 claims description 68
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 52
- 238000011282 treatment Methods 0.000 claims description 52
- 150000003839 salts Chemical class 0.000 claims description 41
- 230000002265 prevention Effects 0.000 claims description 39
- 230000028709 inflammatory response Effects 0.000 claims description 37
- 150000002148 esters Chemical class 0.000 claims description 36
- 230000004044 response Effects 0.000 claims description 35
- 150000001408 amides Chemical class 0.000 claims description 32
- 239000003112 inhibitor Substances 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 230000002401 inhibitory effect Effects 0.000 claims description 26
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 24
- 125000004122 cyclic group Chemical group 0.000 claims description 22
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 22
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- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 14
- 229960003529 diazepam Drugs 0.000 claims description 14
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- 125000005843 halogen group Chemical group 0.000 claims description 12
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 11
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 11
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 7
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- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 5
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 5
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
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- TYUUIESDBRAOMF-UHFFFAOYSA-N 1-[3-[2-chloro-4-(1h-imidazol-2-yl)phenoxy]propyl]-4-methylpiperazine Chemical compound C1CN(C)CCN1CCCOC1=CC=C(C=2NC=CN=2)C=C1Cl TYUUIESDBRAOMF-UHFFFAOYSA-N 0.000 claims description 3
- LWUGEDSDNLDXBV-UHFFFAOYSA-N 1-[3-[3-chloro-4-(4,5-diphenyl-1h-imidazol-2-yl)phenoxy]propyl]-4-methylpiperazine Chemical compound C1CN(C)CCN1CCCOC(C=C1Cl)=CC=C1C1=NC(C=2C=CC=CC=2)=C(C=2C=CC=CC=2)N1 LWUGEDSDNLDXBV-UHFFFAOYSA-N 0.000 claims description 3
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- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 3
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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| MXPA06011021A (es) * | 2004-03-25 | 2007-04-13 | Johnson & Johnson | Compuestos de imidazol. |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| US7589087B2 (en) * | 2006-03-31 | 2009-09-15 | Janssen Pharmaceutica, N.V. | Benzoimidazol-2-yl pyridines as modulators of the histamine H4receptor |
| ME01143B (me) | 2006-03-31 | 2013-03-20 | Janssen Pharmaceutica Nv | BENZOIMIDAZOL-2-IL PIRIMIDINI l PIRAZINI KAO MODULATORI HISTAMINSKOG H4 RECEPTORA |
| US20090069343A1 (en) * | 2006-04-10 | 2009-03-12 | Dunford Paul J | Combination Histamine H1R and H4R Antagonist Therapy for Treating Pruritus |
| CL2007002007A1 (es) * | 2006-07-11 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de benzofuro y benzotienopirimidinas, moduladores del receptor de histamina h4; procedimiento de preparacion; y su uso para tratar trastornos inflamatorios, alergicos, dermatologicos, enfermedades autoinmune, linfaticas y de inmu |
| US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| CL2008000467A1 (es) * | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma |
| JP5439377B2 (ja) * | 2007-09-14 | 2014-03-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒスタミンｈ４受容体のチエノ−及びフロ−ピリミジン調節物質 |
| WO2009079001A1 (en) * | 2007-12-18 | 2009-06-25 | Janssen Pharmaceutica N.V. | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine h4 receptor |
| NZ603074A (en) | 2008-06-12 | 2013-08-30 | Janssen Pharmaceutica Nv | Use of histamine h4 antagonist for the treatment of post-operative adhesions |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| EP2865678A3 (en) * | 2008-06-30 | 2015-05-27 | Janssen Pharmaceutica NV | Crystalline hemi-tartrate form of a benzoimidazol-2-yl pyrimidine derivative |
| CA2742366C (en) * | 2008-12-01 | 2020-09-22 | Targacept, Inc. | Synthesis and salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine |
| US9145396B2 (en) | 2008-12-01 | 2015-09-29 | Targacept, Inc. | Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine |
| EP2201982A1 (en) | 2008-12-24 | 2010-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Histamine H4 receptor antagonists for the treatment of vestibular disorders |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| UA103699C2 (ru) | 2009-08-20 | 2013-11-11 | Еда Рисёрч Энд Девелопмент Ко., Лтд. | Терапия глатирамера ацетатом с низкой частотой |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| US8835444B2 (en) | 2010-02-02 | 2014-09-16 | Novartis Ag | Cyclohexyl amide derivatives as CRF receptor antagonists |
| UY34094A (es) | 2011-05-27 | 2013-01-03 | Novartis Ag | Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina |
| TW201348235A (zh) | 2012-05-03 | 2013-12-01 | Novartis Ag | 作爲格瑞啉受體促效劑之３－螺環哌啶衍生物 |
| EP3378476A1 (en) | 2012-06-08 | 2018-09-26 | Sensorion | H4 receptor inhibitors for treating tinnitus |
| BR112015021463A8 (pt) | 2013-03-06 | 2019-11-19 | Janssen Pharmaceutica Nv | moduladores de benzoimidazol-2-il pirimidina do receptor histamínico h4,seu uso e composição faramacêutica |
| US10414766B2 (en) * | 2015-12-15 | 2019-09-17 | Alembic Pharmaceuticals Limited | Polymorph of Riociguat and its process for the preparation |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| US12370233B2 (en) | 2016-08-31 | 2025-07-29 | Mapi Pharma Ltd. | Depot systems comprising glatiramer acetate |
| WO2018178973A1 (en) | 2017-03-26 | 2018-10-04 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4187213A (en) * | 1978-01-09 | 1980-02-05 | Eastman Kodak Company | Multiheterocyclic ultraviolet stabilizers and their use in organic compositions |
| FR2665161B1 (fr) * | 1990-07-26 | 1992-11-27 | Esteve Labor Dr | Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments. |
| EP0994870A4 (en) * | 1997-06-19 | 2002-10-23 | Smithkline Beecham | NEW IMIDAZOLE COMPOUNDS SUBSTITUTED BY AN ARYLOXYREST |
| DE59911249D1 (de) * | 1998-11-03 | 2005-01-13 | Abbott Gmbh & Co Kg | Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung |
| KR100852362B1 (ko) * | 2000-08-08 | 2008-08-14 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 비-이미다졸 아릴옥시피페리딘 |
| DE60309342T2 (de) * | 2002-08-09 | 2007-05-16 | Eli Lilly And Co., Indianapolis | Benzimidazole und benzothiazole als inhibitoren der map-kinase |
| SE0202462D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel use |
| US20040229927A1 (en) * | 2003-04-10 | 2004-11-18 | Sircar Jagadish C. | Imidazole derivatives for treatment of allergic and hyperproliferative disorders |
| KR20060097024A (ko) * | 2003-09-30 | 2006-09-13 | 얀센 파마슈티카 엔.브이. | 벤조이미다졸 화합물 |
| MXPA06011021A (es) * | 2004-03-25 | 2007-04-13 | Johnson & Johnson | Compuestos de imidazol. |
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- 2005-03-24 KR KR1020067022091A patent/KR101217103B1/ko not_active Expired - Fee Related
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- 2006-09-25 IL IL178287A patent/IL178287A/en active IP Right Grant
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- 2006-10-24 ZA ZA2006/08836A patent/ZA200608836B/en unknown
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- 2006-10-25 CR CR8704A patent/CR8704A/es unknown
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2007
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| Publication | Publication Date | Title |
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| MXPA06011021A (es) | Compuestos de imidazol. | |
| JP4767857B2 (ja) | ベンゾイミダゾール化合物 | |
| US6800645B1 (en) | Substituted azabicyclic compounds | |
| AU2004286933B2 (en) | Benzoimidazole compounds | |
| HK1102020B (en) | Imidazole compounds | |
| MXPA06003579A (en) | Benzoimidazole compounds |
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