MXPA06006050A - Inhibidores de proteina quinasa a base de indolinona. - Google Patents

Inhibidores de proteina quinasa a base de indolinona.

Info

Publication number
MXPA06006050A
MXPA06006050A MXPA06006050A MXPA06006050A MXPA06006050A MX PA06006050 A MXPA06006050 A MX PA06006050A MX PA06006050 A MXPA06006050 A MX PA06006050A MX PA06006050 A MXPA06006050 A MX PA06006050A MX PA06006050 A MXPA06006050 A MX PA06006050A
Authority
MX
Mexico
Prior art keywords
protein kinase
kinase inhibitors
based protein
indolinone
indolinone based
Prior art date
Application number
MXPA06006050A
Other languages
English (en)
Inventor
Congxin Liang
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of MXPA06006050A publication Critical patent/MXPA06006050A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

Derivados de hidroxi carboxi pirrolil-indolinona tienen propiedades de farmaco mejoradas e inesperadas como inhibidores de proteina quinasa y son utiles en tratar desordenes relacionados con actividades de proteina quinasa anormales tales como cancer.
MXPA06006050A 2003-11-26 2004-11-26 Inhibidores de proteina quinasa a base de indolinona. MXPA06006050A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52543003P 2003-11-26 2003-11-26
US54572104P 2004-02-18 2004-02-18
PCT/US2004/039752 WO2005053686A1 (en) 2003-11-26 2004-11-26 Indolinone based protein kinase inhibitors

Publications (1)

Publication Number Publication Date
MXPA06006050A true MXPA06006050A (es) 2007-05-24

Family

ID=34657179

Family Applications (2)

Application Number Title Priority Date Filing Date
MXPA06006049A MXPA06006049A (es) 2003-11-26 2004-11-26 Inhibidores de proteina quinasa avanzados a base de indolinona.
MXPA06006050A MXPA06006050A (es) 2003-11-26 2004-11-26 Inhibidores de proteina quinasa a base de indolinona.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MXPA06006049A MXPA06006049A (es) 2003-11-26 2004-11-26 Inhibidores de proteina quinasa avanzados a base de indolinona.

Country Status (9)

Country Link
US (1) US20080044881A1 (es)
EP (1) EP1686987A4 (es)
JP (1) JP2007512353A (es)
AU (1) AU2004294981A1 (es)
BR (1) BRPI0416994A (es)
CA (1) CA2547066A1 (es)
IL (1) IL175889A0 (es)
MX (2) MXPA06006049A (es)
WO (2) WO2005053686A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008542294A (ja) * 2005-05-26 2008-11-27 ザ スクリプス リサーチ インスティテュート 向上したインドリノン系プロテインキナーゼ阻害剤
CN101282965A (zh) * 2005-09-22 2008-10-08 斯克利普斯研究院 基于烷氧基吲哚酮的蛋白激酶抑制剂
CN101389331A (zh) * 2005-12-29 2009-03-18 斯克里普斯研究学院 基于吲哚满酮的氨基酸衍生物的蛋白激酶抑制剂
CN101054379A (zh) * 2006-04-11 2007-10-17 上海恒瑞医药有限公司 吡咯取代的嘧啶酮衍生物、其制备方法及其在医药上的用途
AU2007296740B2 (en) 2006-09-11 2012-09-27 Curis, Inc. Substituted 2-indolinone as PTK inhibitors containing a zinc binding moiety
AU2007294686B2 (en) 2006-09-15 2013-10-31 Equinox Sciences, Llc Kinase inhibitor compounds
ES2383084T3 (es) 2006-12-04 2012-06-18 Jiangsu Simcere Pharmaceutical R&D Co., Ltd. Derivados de 3-pirrolo[b]ciclohexilen-2-dihidroindolinona y usos de los mismos
KR20110036588A (ko) 2008-07-24 2011-04-07 테바 파마슈티컬 인더스트리즈 리미티드 수니티닙 아세테이트 및 이의 다형을 통한 수니티닙 말레이트의 제조 방법
CN102115472B (zh) * 2010-01-04 2013-12-04 深圳市天和医药科技开发有限公司 3-(2-吡咯亚甲基)氮杂吲哚啉-2-酮衍生物及其制法与应用
CN110016052B (zh) * 2018-01-08 2021-09-28 四川海思科制药有限公司 N-去乙基舒尼替尼的磷酰胺衍生物及其制备方法
CN109293638B (zh) * 2018-03-27 2020-08-14 大连理工大学 一种增强型的靶向识别受体酪氨酸激酶的荧光传感器及细胞膜荧光成像的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0108394B8 (pt) * 2000-02-15 2021-05-25 Upjohn Co inibidores de proteína de quinase de 2-indolinona de pirrol substituído, seus sais e composições farmacêuticas compreendendo os mesmos
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
US6797725B2 (en) * 2001-04-09 2004-09-28 Sugen, Inc. Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
WO2005040116A2 (en) * 2003-10-24 2005-05-06 Schering Aktiengesellschaft Indolinone derivatives and their use in treating disease-states such as cancer

Also Published As

Publication number Publication date
JP2007512353A (ja) 2007-05-17
CA2547066A1 (en) 2005-06-16
WO2005053686A1 (en) 2005-06-16
WO2005053614A3 (en) 2006-02-23
EP1686987A4 (en) 2009-02-25
IL175889A0 (en) 2006-10-05
BRPI0416994A (pt) 2007-02-06
WO2005053614A2 (en) 2005-06-16
EP1686987A2 (en) 2006-08-09
US20080044881A1 (en) 2008-02-21
MXPA06006049A (es) 2007-05-24
AU2004294981A1 (en) 2005-06-16

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