MXPA05011596A - Derivados de amino-propanol como modulador de receptor de esfingosina-1-fosfato. - Google Patents
Derivados de amino-propanol como modulador de receptor de esfingosina-1-fosfato.Info
- Publication number
- MXPA05011596A MXPA05011596A MXPA05011596A MXPA05011596A MXPA05011596A MX PA05011596 A MXPA05011596 A MX PA05011596A MX PA05011596 A MXPA05011596 A MX PA05011596A MX PA05011596 A MXPA05011596 A MX PA05011596A MX PA05011596 A MXPA05011596 A MX PA05011596A
- Authority
- MX
- Mexico
- Prior art keywords
- sphingosine
- amino
- receptor modulator
- phosphate receptor
- propanol derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/094—Esters of phosphoric acids with arylalkanols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0309944 | 2003-04-30 | ||
| GB0329505A GB0329505D0 (en) | 2003-12-19 | 2003-12-19 | Organic compounds |
| GB0329500A GB0329500D0 (en) | 2003-12-19 | 2003-12-19 | Organic compounds |
| PCT/EP2004/004569 WO2004096752A1 (en) | 2003-04-30 | 2004-04-29 | Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05011596A true MXPA05011596A (es) | 2006-01-23 |
Family
ID=33424535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05011596A MXPA05011596A (es) | 2003-04-30 | 2004-04-29 | Derivados de amino-propanol como modulador de receptor de esfingosina-1-fosfato. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7625950B2 (enExample) |
| EP (1) | EP1622860B1 (enExample) |
| JP (1) | JP4603531B2 (enExample) |
| CN (1) | CN1777575B (enExample) |
| AT (1) | ATE547395T1 (enExample) |
| AU (1) | AU2004234066B2 (enExample) |
| BR (1) | BRPI0410025A (enExample) |
| CA (1) | CA2523582A1 (enExample) |
| ES (1) | ES2383298T3 (enExample) |
| MX (1) | MXPA05011596A (enExample) |
| WO (1) | WO2004096752A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003259296A1 (en) | 2002-07-30 | 2004-02-16 | University Of Virginia Patent Foundation | Compounds active in spinigosine 1-phosphate signaling |
| GB0313612D0 (en) * | 2003-06-12 | 2003-07-16 | Novartis Ag | Organic compounds |
| BRPI0413151A (pt) * | 2003-08-28 | 2006-10-03 | Novartis Ag | derivados de amino propanol |
| WO2005041899A2 (en) | 2003-11-03 | 2005-05-12 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
| GB0329498D0 (en) * | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
| US8039674B2 (en) | 2004-06-23 | 2011-10-18 | Ono Pharmaceutical Co., Ltd. | Compound having S1P receptor binding potency and use thereof |
| PT1772145E (pt) | 2004-07-16 | 2011-05-27 | Kyorin Seiyaku Kk | Processo de utiliza??o eficaz de um medicamento e processo respeitante ? preven??o de efeitos secund?rios |
| EP1781595A1 (en) | 2004-08-13 | 2007-05-09 | Praecis Pharmaceuticals Inc. | Methods and compositions for modulating sphingosine-1-phosphate (s1p) receptor activity |
| BRPI0516337A (pt) | 2004-10-12 | 2008-04-29 | Kyorin Seiyaku Kk | processo para a produção de 2- amino-2-[4-(3-benziloxifeniltio) -2- (clorofenil} etil] - 1,3 - hidrocloreto de propanediol e hidratos dos mesmos e produtos intermerdiários para a produção dos mesmos |
| CA2596990A1 (en) | 2005-02-14 | 2006-08-24 | University Of Virginia Patent Foundation | Sphingosine 1-phosphate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups |
| GB0513431D0 (en) | 2005-06-30 | 2005-08-10 | Kherion Technology Ltd | Prophylactic compositions and uses |
| PL1932522T3 (pl) * | 2005-10-07 | 2012-09-28 | Kyorin Seiyaku Kk | Środek terapeutyczny do leczenia choroby wątroby zawierający jako składnik czynny pochodną 2-amino-1,3-propanodiolu |
| PT1961734E (pt) | 2005-12-15 | 2011-10-06 | Mitsubishi Tanabe Pharma Corp | Composto de amina e sua utilização para fins médicos |
| JP2009528274A (ja) | 2006-01-27 | 2009-08-06 | ユニバーシティ オブ バージニア パテント ファンデーション | 神経因性疼痛の治療法 |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| EP1987013A1 (en) | 2006-02-09 | 2008-11-05 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
| WO2007112322A2 (en) | 2006-03-28 | 2007-10-04 | Allergan, Inc. | Indole compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity |
| EP2053038B1 (en) * | 2006-08-08 | 2016-10-05 | Kyorin Pharmaceutical Co., Ltd. | Amino alcohol derivative and immunosuppressive agent having same as an active ingredient |
| EP2058317B1 (en) | 2006-08-08 | 2013-10-16 | Kyorin Pharmaceutical Co., Ltd. | Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient |
| CA2669102A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Tetralin analogs having sphingosine 1-phosphate agonist activity |
| JP2010510250A (ja) | 2006-11-21 | 2010-04-02 | ユニバーシティ オブ バージニア パテント ファンデーション | スフィンゴシン＝１−燐酸受容体アゴニスト活性を有するヒドリンダンアナログ |
| AU2007323557A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity |
| US8524917B2 (en) | 2007-01-11 | 2013-09-03 | Allergan, Inc. | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| ES2581879T3 (es) * | 2007-06-14 | 2016-09-08 | Mitsubishi Tanabe Pharma Corporation | Compuesto de amina y su uso farmacéutico |
| KR20100067677A (ko) | 2007-09-24 | 2010-06-21 | 알러간, 인코포레이티드 | 스핑고신-1-포스페이트 (ｓｐ1) 생물학적 활성을 갖는 아릴 또는 헤테로아릴 기를 함유하는 인돌 화합물 |
| WO2009099174A1 (ja) | 2008-02-07 | 2009-08-13 | Kyorin Pharmaceutical Co., Ltd. | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
| RU2010149311A (ru) | 2008-05-08 | 2012-06-20 | Аллерган, Инк. (Us) | ТЕРАПЕВТИЧЕСКИ ПОЛЕЗНЫЕ ЗАМЕЩЕННЫЕ 1,7-ДИФЕНИЛ-1,2,3,5,6,7-ГЕКСАГИДРОПИРИДО [3,2,1-ij]ХИНОЛИНОВЫЕ СОЕДИНЕНИЯ |
| US8143291B2 (en) | 2008-05-09 | 2012-03-27 | Allergan, Inc. | Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity |
| SI2326621T1 (sl) | 2008-07-23 | 2016-10-28 | Arena Pharmaceuticals, Inc. | Substituirani derivati 1,2,3,4-tetrahidrociklopenta(b)indol-3-il)ocetne kisline, uporabni pri zdravljenju avtoimunskih in vnetnih motenj |
| NZ591001A (en) | 2008-08-27 | 2012-11-30 | Arena Pharm Inc | Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
| BR112012009670A2 (pt) * | 2009-10-23 | 2016-05-17 | Allergan Inc | compostos de cumarina como moduladores de receptor com utilidade terapêutica |
| RU2012128650A (ru) * | 2009-12-10 | 2014-01-20 | Новартис Аг | Галогенированные производные fty720 |
| SG10201500639TA (en) | 2010-01-27 | 2015-03-30 | Arena Pharm Inc | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| CN105503882B (zh) | 2010-03-03 | 2019-07-05 | 艾尼纳制药公司 | 制备s1p1受体调节剂及其晶体形式的方法 |
| CN102260178A (zh) * | 2010-05-25 | 2011-11-30 | 中国医学科学院药物研究所 | 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途 |
| CN116850181A (zh) | 2015-01-06 | 2023-10-10 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
| AU2016284162A1 (en) | 2015-06-22 | 2018-02-01 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(Compound1) for use in SIP1 receptor-associated disorders |
| CA3053416A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
| AU2018220521A1 (en) | 2017-02-16 | 2019-09-05 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
| WO2019236757A1 (en) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0778263B1 (en) | 1994-08-22 | 2002-01-09 | Welfide Corporation | Benzene compound and medicinal use thereof |
| GB2309868A (en) * | 1996-01-30 | 1997-08-06 | Sony Corp | Radio receiver detects FCCH synchronising signal |
| SI1319651T1 (en) * | 1997-04-04 | 2005-10-31 | Mitsubishi Pharma Corporation | 2-Aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor |
| ATE298741T1 (de) | 1997-04-10 | 2005-07-15 | Pharmacia & Upjohn Co Llc | Polyaromatische verbindungen zur behandlung von herpes-infektionen |
| IL157773A0 (en) * | 2001-03-26 | 2004-03-28 | Novartis Ag | 2-amino-propanol derivatives |
| JP2002316985A (ja) * | 2001-04-20 | 2002-10-31 | Sankyo Co Ltd | ベンゾチオフェン誘導体 |
| WO2003029184A1 (en) * | 2001-09-27 | 2003-04-10 | Kyorin Pharmaceutical Co., Ltd. | Diaryl ether derivative, addition salt thereof, and immunosuppressant |
| CN1329372C (zh) * | 2001-09-27 | 2007-08-01 | 杏林制药株式会社 | 二芳基硫醚衍生物及其加成盐和免疫抑制剂 |
| BR0314113A (pt) * | 2002-09-13 | 2005-07-12 | Novartis Ag | Derivados de amino propanol |
-
2004
- 2004-04-29 AU AU2004234066A patent/AU2004234066B2/en not_active Ceased
- 2004-04-29 CN CN2004800110595A patent/CN1777575B/zh not_active Expired - Fee Related
- 2004-04-29 WO PCT/EP2004/004569 patent/WO2004096752A1/en not_active Ceased
- 2004-04-29 AT AT04730206T patent/ATE547395T1/de active
- 2004-04-29 BR BRPI0410025-5A patent/BRPI0410025A/pt not_active IP Right Cessation
- 2004-04-29 ES ES04730206T patent/ES2383298T3/es not_active Expired - Lifetime
- 2004-04-29 MX MXPA05011596A patent/MXPA05011596A/es active IP Right Grant
- 2004-04-29 EP EP04730206A patent/EP1622860B1/en not_active Expired - Lifetime
- 2004-04-29 JP JP2006505327A patent/JP4603531B2/ja not_active Expired - Fee Related
- 2004-04-29 US US10/554,556 patent/US7625950B2/en not_active Expired - Fee Related
- 2004-04-29 CA CA002523582A patent/CA2523582A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004234066A1 (en) | 2004-11-11 |
| ES2383298T3 (es) | 2012-06-20 |
| US20060211658A1 (en) | 2006-09-21 |
| AU2004234066B2 (en) | 2008-02-21 |
| CN1777575B (zh) | 2010-05-12 |
| EP1622860B1 (en) | 2012-02-29 |
| CN1777575A (zh) | 2006-05-24 |
| JP2006524660A (ja) | 2006-11-02 |
| JP4603531B2 (ja) | 2010-12-22 |
| BRPI0410025A (pt) | 2006-04-25 |
| WO2004096752A1 (en) | 2004-11-11 |
| US7625950B2 (en) | 2009-12-01 |
| CA2523582A1 (en) | 2004-11-11 |
| EP1622860A1 (en) | 2006-02-08 |
| ATE547395T1 (de) | 2012-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| HH | Correction or change in general |