MXPA05008315A - Nuevos derivados de 8-aza-biciclo[3.2.1]octano y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina. - Google Patents
Nuevos derivados de 8-aza-biciclo[3.2.1]octano y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina.Info
- Publication number
- MXPA05008315A MXPA05008315A MXPA05008315A MXPA05008315A MXPA05008315A MX PA05008315 A MXPA05008315 A MX PA05008315A MX PA05008315 A MXPA05008315 A MX PA05008315A MX PA05008315 A MXPA05008315 A MX PA05008315A MX PA05008315 A MXPA05008315 A MX PA05008315A
- Authority
- MX
- Mexico
- Prior art keywords
- aza
- bicyclo
- octane
- methyl
- chlorophenyl
- Prior art date
Links
- DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical class C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 title claims description 6
- 239000003112 inhibitor Substances 0.000 title abstract description 5
- 230000001561 neurotransmitter reuptake Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 74
- 238000000034 method Methods 0.000 claims abstract description 50
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical class CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
- -1 hydroxy, amino Chemical group 0.000 claims description 93
- 150000003839 salts Chemical class 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 41
- 125000000217 alkyl group Chemical group 0.000 claims description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 20
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- 125000003342 alkenyl group Chemical group 0.000 claims description 15
- 125000000304 alkynyl group Chemical group 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- 239000001257 hydrogen Substances 0.000 claims description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
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- 208000035475 disorder Diseases 0.000 claims description 14
- 125000003545 alkoxy group Chemical group 0.000 claims description 13
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 13
- 125000001624 naphthyl group Chemical group 0.000 claims description 11
- 239000002858 neurotransmitter agent Substances 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 11
- 238000011282 treatment Methods 0.000 claims description 10
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 9
- 230000009103 reabsorption Effects 0.000 claims description 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- 230000002265 prevention Effects 0.000 claims description 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
- 230000005764 inhibitory process Effects 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 7
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- OUTREUMPVYZFKZ-VIHIWDAPSA-N (3r,4s)-3-(3-chlorophenyl)-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@@H]1C2CCC(C[C@H]1C=1C=C(Cl)C=CC=1)N2C)OC1=CC=CC(Cl)=C1Cl OUTREUMPVYZFKZ-VIHIWDAPSA-N 0.000 claims description 3
- CGQKKDKUPUHQQG-VZDIDWBNSA-N (3s,4r)-3-(3-chlorophenyl)-4-[(2,3-difluorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(C[C@@H]1C=1C=C(Cl)C=CC=1)N2C)OC1=CC=CC(F)=C1F CGQKKDKUPUHQQG-VZDIDWBNSA-N 0.000 claims description 3
- FWCHGXSOLMAOCD-WBFXSEPVSA-N (3s,4r)-3-(3-chlorophenyl)-4-[(2,3-dimethoxyphenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound COC1=CC=CC(OC[C@@H]2[C@H](CC3CCC2N3C)C=2C=C(Cl)C=CC=2)=C1OC FWCHGXSOLMAOCD-WBFXSEPVSA-N 0.000 claims description 3
- DAQHJYNGLVDBGR-IOSBVQAASA-N (3s,4r)-3-cyclopropyl-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(C[C@H]1C1CC1)N2C)OC1=CC=CC(Cl)=C1Cl DAQHJYNGLVDBGR-IOSBVQAASA-N 0.000 claims description 3
- JLLIPUGDCXAUEP-OYNVLQORSA-N (3s,4r)-4-[(2,3-dichlorophenoxy)methyl]-3-ethyl-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(N2C)C[C@@H]1CC)OC1=CC=CC(Cl)=C1Cl JLLIPUGDCXAUEP-OYNVLQORSA-N 0.000 claims description 3
- SMCCFJLGYWDNNQ-IOSBVQAASA-N (3s,4r)-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-3-propan-2-yl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(N2C)C[C@H]1C(C)C)OC1=CC=CC(Cl)=C1Cl SMCCFJLGYWDNNQ-IOSBVQAASA-N 0.000 claims description 3
- BWYCGNAZYLFYDG-VZDIDWBNSA-N (3s,4r)-4-[(2-chloro-3-fluorophenoxy)methyl]-3-(3-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(C[C@@H]1C=1C=C(Cl)C=CC=1)N2C)OC1=CC=CC(F)=C1Cl BWYCGNAZYLFYDG-VZDIDWBNSA-N 0.000 claims description 3
- 125000001617 2,3-dimethoxy phenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 3
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- MKTXIVUGJMMDPT-UJEKJILKSA-N (3s,4r)-3-butyl-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(N2C)C[C@@H]1CCCC)OC1=CC=CC(Cl)=C1Cl MKTXIVUGJMMDPT-UJEKJILKSA-N 0.000 claims description 2
- MIFKAKHTONPRMG-UJEKJILKSA-N (3s,4r)-3-butyl-4-[(2,3-dichlorophenyl)sulfanylmethyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(N2C)C[C@@H]1CCCC)SC1=CC=CC(Cl)=C1Cl MIFKAKHTONPRMG-UJEKJILKSA-N 0.000 claims description 2
- DYDDLCLIKCENRH-FFKUYJCKSA-N (3s,4r)-3-butyl-8-methyl-4-(naphthalen-1-yloxymethyl)-8-azabicyclo[3.2.1]octane Chemical compound C1=CC=C2C(OC[C@H]3C4CCC(N4C)C[C@@H]3CCCC)=CC=CC2=C1 DYDDLCLIKCENRH-FFKUYJCKSA-N 0.000 claims description 2
- WBSMPPDAPDGBGN-ZBOXLXRLSA-N (4r)-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(CC1)N2C)OC1=CC=CC(Cl)=C1Cl WBSMPPDAPDGBGN-ZBOXLXRLSA-N 0.000 claims description 2
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- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300212 | 2003-02-12 | ||
| US44810703P | 2003-02-20 | 2003-02-20 | |
| PCT/EP2004/050106 WO2004072075A1 (en) | 2003-02-12 | 2004-02-10 | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05008315A true MXPA05008315A (es) | 2005-09-20 |
Family
ID=32870666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05008315A MXPA05008315A (es) | 2003-02-12 | 2004-02-10 | Nuevos derivados de 8-aza-biciclo[3.2.1]octano y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7250425B2 (enExample) |
| EP (1) | EP1594874A1 (enExample) |
| JP (1) | JP2006517567A (enExample) |
| AU (1) | AU2004212165B2 (enExample) |
| CA (1) | CA2515732A1 (enExample) |
| MX (1) | MXPA05008315A (enExample) |
| NZ (1) | NZ541248A (enExample) |
| WO (1) | WO2004072075A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005500371A (ja) * | 2001-08-08 | 2005-01-06 | ニューロサーチ、アクティーゼルスカブ | 置換されたアミン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| WO2005039580A1 (en) * | 2003-10-16 | 2005-05-06 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor |
| EP1708707A1 (en) * | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| CA2553649A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| EP1755602A1 (en) * | 2004-06-04 | 2007-02-28 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for the inhibition of beta-amyloid (a beta 40 and a beta 42) generation |
| EP1779851A1 (en) * | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
| WO2009135678A2 (en) * | 2008-05-08 | 2009-11-12 | Detrey Gmbh Dentsply | Radical polymerisation inhibitors for light-curable dental materials |
| CN110520129A (zh) | 2017-02-17 | 2019-11-29 | 特维娜有限公司 | 含有5元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN110446495B (zh) | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN116406268A (zh) | 2020-10-27 | 2023-07-07 | 特维娜有限公司 | δ-阿片样物质调节剂的结晶和无定形形式 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU672052B2 (en) | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| US5554626A (en) | 1992-12-23 | 1996-09-10 | Neurosearch A/S | Substituted heterocyclic compounds as dopamine-reuptake inhibitors |
| TR199800780T2 (xx) | 1995-11-02 | 1998-07-21 | Neurosearch A/S | Kayna�m�� tropan t�revleri, haz�rlan��lar� ve kullan�mlar�. |
| ZA971525B (en) | 1996-02-22 | 1997-10-21 | Neurosearch As | Tropane derivatives, their preparation and use. |
| WO2002076440A2 (en) * | 2001-03-23 | 2002-10-03 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
| JP2005508872A (ja) * | 2001-05-23 | 2005-04-07 | ニューロサーチ、アクティーゼルスカブ | トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| JP2005500371A (ja) * | 2001-08-08 | 2005-01-06 | ニューロサーチ、アクティーゼルスカブ | 置換されたアミン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
| US7381733B2 (en) * | 2001-11-30 | 2008-06-03 | Neurosearch A/S | Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases |
-
2004
- 2004-02-10 JP JP2006502017A patent/JP2006517567A/ja not_active Ceased
- 2004-02-10 AU AU2004212165A patent/AU2004212165B2/en not_active Ceased
- 2004-02-10 US US10/543,828 patent/US7250425B2/en not_active Expired - Fee Related
- 2004-02-10 MX MXPA05008315A patent/MXPA05008315A/es active IP Right Grant
- 2004-02-10 NZ NZ541248A patent/NZ541248A/en not_active IP Right Cessation
- 2004-02-10 CA CA002515732A patent/CA2515732A1/en not_active Abandoned
- 2004-02-10 EP EP04709632A patent/EP1594874A1/en not_active Withdrawn
- 2004-02-10 WO PCT/EP2004/050106 patent/WO2004072075A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004212165B2 (en) | 2010-02-18 |
| NZ541248A (en) | 2008-04-30 |
| WO2004072075A1 (en) | 2004-08-26 |
| US20060148847A1 (en) | 2006-07-06 |
| CA2515732A1 (en) | 2004-08-26 |
| JP2006517567A (ja) | 2006-07-27 |
| US7250425B2 (en) | 2007-07-31 |
| AU2004212165A1 (en) | 2004-08-26 |
| EP1594874A1 (en) | 2005-11-16 |
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| FG | Grant or registration |