MXPA05008315A - Nuevos derivados de 8-aza-biciclo[3.2.1]octano y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina. - Google Patents
Nuevos derivados de 8-aza-biciclo[3.2.1]octano y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina.Info
- Publication number
- MXPA05008315A MXPA05008315A MXPA05008315A MXPA05008315A MXPA05008315A MX PA05008315 A MXPA05008315 A MX PA05008315A MX PA05008315 A MXPA05008315 A MX PA05008315A MX PA05008315 A MXPA05008315 A MX PA05008315A MX PA05008315 A MXPA05008315 A MX PA05008315A
- Authority
- MX
- Mexico
- Prior art keywords
- aza
- bicyclo
- octane
- methyl
- chlorophenyl
- Prior art date
Links
- DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical class C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 title claims description 6
- 239000003112 inhibitor Substances 0.000 title abstract description 5
- 230000001561 neurotransmitter reuptake Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 74
- 238000000034 method Methods 0.000 claims abstract description 50
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical class CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
- -1 hydroxy, amino Chemical group 0.000 claims description 93
- 150000003839 salts Chemical class 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 41
- 125000000217 alkyl group Chemical group 0.000 claims description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 20
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- 125000003342 alkenyl group Chemical group 0.000 claims description 15
- 125000000304 alkynyl group Chemical group 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- 239000001257 hydrogen Substances 0.000 claims description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
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- 208000035475 disorder Diseases 0.000 claims description 14
- 125000003545 alkoxy group Chemical group 0.000 claims description 13
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 13
- 125000001624 naphthyl group Chemical group 0.000 claims description 11
- 239000002858 neurotransmitter agent Substances 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 11
- 238000011282 treatment Methods 0.000 claims description 10
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 9
- 230000009103 reabsorption Effects 0.000 claims description 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- 230000002265 prevention Effects 0.000 claims description 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
- 230000005764 inhibitory process Effects 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 7
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- OUTREUMPVYZFKZ-VIHIWDAPSA-N (3r,4s)-3-(3-chlorophenyl)-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@@H]1C2CCC(C[C@H]1C=1C=C(Cl)C=CC=1)N2C)OC1=CC=CC(Cl)=C1Cl OUTREUMPVYZFKZ-VIHIWDAPSA-N 0.000 claims description 3
- CGQKKDKUPUHQQG-VZDIDWBNSA-N (3s,4r)-3-(3-chlorophenyl)-4-[(2,3-difluorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(C[C@@H]1C=1C=C(Cl)C=CC=1)N2C)OC1=CC=CC(F)=C1F CGQKKDKUPUHQQG-VZDIDWBNSA-N 0.000 claims description 3
- FWCHGXSOLMAOCD-WBFXSEPVSA-N (3s,4r)-3-(3-chlorophenyl)-4-[(2,3-dimethoxyphenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound COC1=CC=CC(OC[C@@H]2[C@H](CC3CCC2N3C)C=2C=C(Cl)C=CC=2)=C1OC FWCHGXSOLMAOCD-WBFXSEPVSA-N 0.000 claims description 3
- DAQHJYNGLVDBGR-IOSBVQAASA-N (3s,4r)-3-cyclopropyl-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(C[C@H]1C1CC1)N2C)OC1=CC=CC(Cl)=C1Cl DAQHJYNGLVDBGR-IOSBVQAASA-N 0.000 claims description 3
- JLLIPUGDCXAUEP-OYNVLQORSA-N (3s,4r)-4-[(2,3-dichlorophenoxy)methyl]-3-ethyl-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(N2C)C[C@@H]1CC)OC1=CC=CC(Cl)=C1Cl JLLIPUGDCXAUEP-OYNVLQORSA-N 0.000 claims description 3
- SMCCFJLGYWDNNQ-IOSBVQAASA-N (3s,4r)-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-3-propan-2-yl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(N2C)C[C@H]1C(C)C)OC1=CC=CC(Cl)=C1Cl SMCCFJLGYWDNNQ-IOSBVQAASA-N 0.000 claims description 3
- BWYCGNAZYLFYDG-VZDIDWBNSA-N (3s,4r)-4-[(2-chloro-3-fluorophenoxy)methyl]-3-(3-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(C[C@@H]1C=1C=C(Cl)C=CC=1)N2C)OC1=CC=CC(F)=C1Cl BWYCGNAZYLFYDG-VZDIDWBNSA-N 0.000 claims description 3
- 125000001617 2,3-dimethoxy phenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 3
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- MKTXIVUGJMMDPT-UJEKJILKSA-N (3s,4r)-3-butyl-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(N2C)C[C@@H]1CCCC)OC1=CC=CC(Cl)=C1Cl MKTXIVUGJMMDPT-UJEKJILKSA-N 0.000 claims description 2
- MIFKAKHTONPRMG-UJEKJILKSA-N (3s,4r)-3-butyl-4-[(2,3-dichlorophenyl)sulfanylmethyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(N2C)C[C@@H]1CCCC)SC1=CC=CC(Cl)=C1Cl MIFKAKHTONPRMG-UJEKJILKSA-N 0.000 claims description 2
- DYDDLCLIKCENRH-FFKUYJCKSA-N (3s,4r)-3-butyl-8-methyl-4-(naphthalen-1-yloxymethyl)-8-azabicyclo[3.2.1]octane Chemical compound C1=CC=C2C(OC[C@H]3C4CCC(N4C)C[C@@H]3CCCC)=CC=CC2=C1 DYDDLCLIKCENRH-FFKUYJCKSA-N 0.000 claims description 2
- WBSMPPDAPDGBGN-ZBOXLXRLSA-N (4r)-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(CC1)N2C)OC1=CC=CC(Cl)=C1Cl WBSMPPDAPDGBGN-ZBOXLXRLSA-N 0.000 claims description 2
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300212 | 2003-02-12 | ||
| US44810703P | 2003-02-20 | 2003-02-20 | |
| PCT/EP2004/050106 WO2004072075A1 (en) | 2003-02-12 | 2004-02-10 | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05008315A true MXPA05008315A (es) | 2005-09-20 |
Family
ID=32870666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05008315A MXPA05008315A (es) | 2003-02-12 | 2004-02-10 | Nuevos derivados de 8-aza-biciclo[3.2.1]octano y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7250425B2 (enExample) |
| EP (1) | EP1594874A1 (enExample) |
| JP (1) | JP2006517567A (enExample) |
| AU (1) | AU2004212165B2 (enExample) |
| CA (1) | CA2515732A1 (enExample) |
| MX (1) | MXPA05008315A (enExample) |
| NZ (1) | NZ541248A (enExample) |
| WO (1) | WO2004072075A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040235906A1 (en) * | 2001-08-08 | 2004-11-25 | Gouliaev Alex Haahr | Substituted amine derivatives and their use as monoamine neurotransmitter re-up-take inhibitors |
| MXPA06003762A (es) * | 2003-10-16 | 2006-06-14 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de recaptacion de neurotransmisor monoamina y un inhibidor de acetilcolinesterasa. |
| AU2005205882A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist |
| EP1727547A1 (en) * | 2004-01-22 | 2006-12-06 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| WO2005117874A1 (en) * | 2004-06-04 | 2005-12-15 | Neurosearch A/S | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION |
| EP1779851A1 (en) * | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
| WO2009135677A1 (en) * | 2008-05-08 | 2009-11-12 | Dentsply Detrey Gmbh | Radical polymerisation initiators for light-curable dental materials |
| CA3052480A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CN110446495B (zh) | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| US5554626A (en) | 1992-12-23 | 1996-09-10 | Neurosearch A/S | Substituted heterocyclic compounds as dopamine-reuptake inhibitors |
| KR100277482B1 (ko) | 1995-11-02 | 2001-01-15 | 페더 벨링 | 신경전달물질 재흡수 저해제인 융합구조의 트로판 유도체 |
| JP3238414B2 (ja) | 1996-02-22 | 2001-12-17 | ニューロサーチ・アクティーゼルスカブ | トロパン―誘導体、その製造方法及びその使用方法 |
| AU2002306848A1 (en) * | 2001-03-23 | 2002-10-08 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
| WO2002102801A1 (en) * | 2001-05-23 | 2002-12-27 | Neurosearch A/S | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US20040235906A1 (en) | 2001-08-08 | 2004-11-25 | Gouliaev Alex Haahr | Substituted amine derivatives and their use as monoamine neurotransmitter re-up-take inhibitors |
| US7381733B2 (en) | 2001-11-30 | 2008-06-03 | Neurosearch A/S | Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases |
-
2004
- 2004-02-10 EP EP04709632A patent/EP1594874A1/en not_active Withdrawn
- 2004-02-10 NZ NZ541248A patent/NZ541248A/en not_active IP Right Cessation
- 2004-02-10 AU AU2004212165A patent/AU2004212165B2/en not_active Ceased
- 2004-02-10 MX MXPA05008315A patent/MXPA05008315A/es active IP Right Grant
- 2004-02-10 WO PCT/EP2004/050106 patent/WO2004072075A1/en not_active Ceased
- 2004-02-10 US US10/543,828 patent/US7250425B2/en not_active Expired - Fee Related
- 2004-02-10 CA CA002515732A patent/CA2515732A1/en not_active Abandoned
- 2004-02-10 JP JP2006502017A patent/JP2006517567A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2515732A1 (en) | 2004-08-26 |
| JP2006517567A (ja) | 2006-07-27 |
| WO2004072075A1 (en) | 2004-08-26 |
| EP1594874A1 (en) | 2005-11-16 |
| AU2004212165B2 (en) | 2010-02-18 |
| NZ541248A (en) | 2008-04-30 |
| US20060148847A1 (en) | 2006-07-06 |
| US7250425B2 (en) | 2007-07-31 |
| AU2004212165A1 (en) | 2004-08-26 |
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| FG | Grant or registration |