JP2006517567A - 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法 - Google Patents
新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法 Download PDFInfo
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- JP2006517567A JP2006517567A JP2006502017A JP2006502017A JP2006517567A JP 2006517567 A JP2006517567 A JP 2006517567A JP 2006502017 A JP2006502017 A JP 2006502017A JP 2006502017 A JP2006502017 A JP 2006502017A JP 2006517567 A JP2006517567 A JP 2006517567A
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- Prior art keywords
- aza
- bicyclo
- octane
- methyl
- chlorophenyl
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- 238000000034 method Methods 0.000 title claims abstract description 58
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- 125000000217 alkyl group Chemical group 0.000 claims description 28
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- MKTXIVUGJMMDPT-UJEKJILKSA-N (3s,4r)-3-butyl-4-[(2,3-dichlorophenoxy)methyl]-8-methyl-8-azabicyclo[3.2.1]octane Chemical compound C([C@H]1C2CCC(N2C)C[C@@H]1CCCC)OC1=CC=CC(Cl)=C1Cl MKTXIVUGJMMDPT-UJEKJILKSA-N 0.000 claims description 2
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Anesthesiology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300212 | 2003-02-12 | ||
| US44810703P | 2003-02-20 | 2003-02-20 | |
| PCT/EP2004/050106 WO2004072075A1 (en) | 2003-02-12 | 2004-02-10 | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006517567A true JP2006517567A (ja) | 2006-07-27 |
| JP2006517567A5 JP2006517567A5 (enExample) | 2011-01-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006502017A Ceased JP2006517567A (ja) | 2003-02-12 | 2004-02-10 | 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7250425B2 (enExample) |
| EP (1) | EP1594874A1 (enExample) |
| JP (1) | JP2006517567A (enExample) |
| AU (1) | AU2004212165B2 (enExample) |
| CA (1) | CA2515732A1 (enExample) |
| MX (1) | MXPA05008315A (enExample) |
| NZ (1) | NZ541248A (enExample) |
| WO (1) | WO2004072075A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040235906A1 (en) * | 2001-08-08 | 2004-11-25 | Gouliaev Alex Haahr | Substituted amine derivatives and their use as monoamine neurotransmitter re-up-take inhibitors |
| MXPA06003762A (es) * | 2003-10-16 | 2006-06-14 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de recaptacion de neurotransmisor monoamina y un inhibidor de acetilcolinesterasa. |
| AU2005205882A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an N-methyl-D-aspartate (NMDA) receptors antagonist |
| EP1727547A1 (en) * | 2004-01-22 | 2006-12-06 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| WO2005117874A1 (en) * | 2004-06-04 | 2005-12-15 | Neurosearch A/S | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION |
| EP1779851A1 (en) * | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
| WO2009135677A1 (en) * | 2008-05-08 | 2009-11-12 | Dentsply Detrey Gmbh | Radical polymerisation initiators for light-curable dental materials |
| CA3052480A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| CN110446495B (zh) | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06293758A (ja) * | 1992-12-23 | 1994-10-21 | Neurosearch As | 抗鬱病および抗パーキンソン氏病化合物 |
| WO2002076440A2 (en) * | 2001-03-23 | 2002-10-03 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
| WO2002102801A1 (en) * | 2001-05-23 | 2002-12-27 | Neurosearch A/S | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5554626A (en) | 1992-12-23 | 1996-09-10 | Neurosearch A/S | Substituted heterocyclic compounds as dopamine-reuptake inhibitors |
| KR100277482B1 (ko) | 1995-11-02 | 2001-01-15 | 페더 벨링 | 신경전달물질 재흡수 저해제인 융합구조의 트로판 유도체 |
| JP3238414B2 (ja) | 1996-02-22 | 2001-12-17 | ニューロサーチ・アクティーゼルスカブ | トロパン―誘導体、その製造方法及びその使用方法 |
| US20040235906A1 (en) | 2001-08-08 | 2004-11-25 | Gouliaev Alex Haahr | Substituted amine derivatives and their use as monoamine neurotransmitter re-up-take inhibitors |
| US7381733B2 (en) | 2001-11-30 | 2008-06-03 | Neurosearch A/S | Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases |
-
2004
- 2004-02-10 EP EP04709632A patent/EP1594874A1/en not_active Withdrawn
- 2004-02-10 NZ NZ541248A patent/NZ541248A/en not_active IP Right Cessation
- 2004-02-10 AU AU2004212165A patent/AU2004212165B2/en not_active Ceased
- 2004-02-10 MX MXPA05008315A patent/MXPA05008315A/es active IP Right Grant
- 2004-02-10 WO PCT/EP2004/050106 patent/WO2004072075A1/en not_active Ceased
- 2004-02-10 US US10/543,828 patent/US7250425B2/en not_active Expired - Fee Related
- 2004-02-10 CA CA002515732A patent/CA2515732A1/en not_active Abandoned
- 2004-02-10 JP JP2006502017A patent/JP2006517567A/ja not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06293758A (ja) * | 1992-12-23 | 1994-10-21 | Neurosearch As | 抗鬱病および抗パーキンソン氏病化合物 |
| WO2002076440A2 (en) * | 2001-03-23 | 2002-10-03 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
| WO2002102801A1 (en) * | 2001-05-23 | 2002-12-27 | Neurosearch A/S | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2515732A1 (en) | 2004-08-26 |
| WO2004072075A1 (en) | 2004-08-26 |
| EP1594874A1 (en) | 2005-11-16 |
| AU2004212165B2 (en) | 2010-02-18 |
| MXPA05008315A (es) | 2005-09-20 |
| NZ541248A (en) | 2008-04-30 |
| US20060148847A1 (en) | 2006-07-06 |
| US7250425B2 (en) | 2007-07-31 |
| AU2004212165A1 (en) | 2004-08-26 |
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