MXPA05005315A - Dispositivos medicos que incorporan rapamicina deuterizada para la administracion controlada de la misma. - Google Patents

Dispositivos medicos que incorporan rapamicina deuterizada para la administracion controlada de la misma.

Info

Publication number
MXPA05005315A
MXPA05005315A MXPA05005315A MXPA05005315A MXPA05005315A MX PA05005315 A MXPA05005315 A MX PA05005315A MX PA05005315 A MXPA05005315 A MX PA05005315A MX PA05005315 A MXPA05005315 A MX PA05005315A MX PA05005315 A MXPA05005315 A MX PA05005315A
Authority
MX
Mexico
Prior art keywords
rapamycin
deuterated
medical devices
controlled delivery
devices incorporating
Prior art date
Application number
MXPA05005315A
Other languages
English (en)
Inventor
Koziak Joseph
Original Assignee
Isotechnika International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotechnika International Inc filed Critical Isotechnika International Inc
Publication of MXPA05005315A publication Critical patent/MXPA05005315A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Abstract

La rapamicina deuterizada puede introducirse controlablemente a las ubicaciones objetivo del cuerpo del paciente al utilizar un dispositivo medico implantable que tienen una estructura incorporada con un agente terapeutico que comprende la rapamicina deuterizada. Las rapamicinas deuterizadas representativas incluyen epi-7-deuterometil rapamicina, 7,43-d6 rapamicina, 7-deuterometil rapamicina y 31,42-d2-rapamicina e isomeros de los mismos y mezclas de los mismos. La rapamicina deuterizada tambien puede ser glicosilada.
MXPA05005315A 2002-11-20 2003-11-17 Dispositivos medicos que incorporan rapamicina deuterizada para la administracion controlada de la misma. MXPA05005315A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/301,504 US6884429B2 (en) 1997-09-05 2002-11-20 Medical devices incorporating deuterated rapamycin for controlled delivery thereof
PCT/US2003/036838 WO2004045668A1 (en) 2002-11-20 2003-11-17 Medical devices incorporating deuterated rapamycin for controlled delivery thereof

Publications (1)

Publication Number Publication Date
MXPA05005315A true MXPA05005315A (es) 2005-10-26

Family

ID=32324552

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05005315A MXPA05005315A (es) 2002-11-20 2003-11-17 Dispositivos medicos que incorporan rapamicina deuterizada para la administracion controlada de la misma.

Country Status (11)

Country Link
US (1) US6884429B2 (es)
EP (1) EP1562654A1 (es)
JP (1) JP2006512943A (es)
KR (1) KR20050071702A (es)
AU (1) AU2003287677A1 (es)
BR (1) BR0315700A (es)
CA (1) CA2505080A1 (es)
MX (1) MXPA05005315A (es)
NZ (1) NZ539470A (es)
TW (1) TWI293253B (es)
WO (1) WO2004045668A1 (es)

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TWI293253B (en) 2008-02-11
NZ539470A (en) 2006-11-30
US20030130206A1 (en) 2003-07-10
CA2505080A1 (en) 2004-06-03
US6884429B2 (en) 2005-04-26
WO2004045668A1 (en) 2004-06-03
JP2006512943A (ja) 2006-04-20
EP1562654A1 (en) 2005-08-17
BR0315700A (pt) 2005-09-06
AU2003287677A1 (en) 2004-06-15
KR20050071702A (ko) 2005-07-07

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