MXPA04008800A - Derivados de 4-azasteroides fluorados como moduladores del receptor de androgenos. - Google Patents
Derivados de 4-azasteroides fluorados como moduladores del receptor de androgenos.Info
- Publication number
- MXPA04008800A MXPA04008800A MXPA04008800A MXPA04008800A MXPA04008800A MX PA04008800 A MXPA04008800 A MX PA04008800A MX PA04008800 A MXPA04008800 A MX PA04008800A MX PA04008800 A MXPA04008800 A MX PA04008800A MX PA04008800 A MXPA04008800 A MX PA04008800A
- Authority
- MX
- Mexico
- Prior art keywords
- methyl
- aza
- fluoro
- carboxamide
- oxo
- Prior art date
Links
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36382202P | 2002-03-13 | 2002-03-13 | |
| PCT/US2003/008277 WO2003077919A1 (en) | 2002-03-13 | 2003-03-07 | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
Publications (1)
| Publication Number | Publication Date |
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| MXPA04008800A true MXPA04008800A (es) | 2004-11-26 |
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| IL (2) | IL163825A0 (enExample) |
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| US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US7772433B2 (en) | 2002-02-28 | 2010-08-10 | University Of Tennessee Research Foundation | SARMS and method of use thereof |
| NZ534946A (en) * | 2002-03-13 | 2007-05-31 | Merck & Co Inc | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
| BR0308901A (pt) * | 2002-05-10 | 2005-01-04 | Hoffmann La Roche | ácidos bisfosfÈnicos para tratamento e prevenção de osteoporose |
| US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
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| EP1663228A4 (en) * | 2003-09-10 | 2010-10-06 | Merck Sharp & Dohme | 17-heterocyclic 4-azasteroid derivatives as androgen receptor modules |
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| CN1930181A (zh) | 2004-01-07 | 2007-03-14 | 恩多研究公司 | 螺旋12定向的甾族药品 |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| JP2007534757A (ja) * | 2004-04-28 | 2007-11-29 | メルク エンド カムパニー インコーポレーテッド | アンドロゲン受容体モジュレーターとしてのフッ素付加４−アザステロイド |
| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| CA2576988A1 (en) * | 2004-08-25 | 2006-03-09 | Merck & Co., Inc. | Androgen receptor modulators |
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| TW200730505A (en) | 2005-12-07 | 2007-08-16 | Merck & Co Inc | Polymorphs of an androgen receptor modulator |
| US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
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| US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
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| CN101990541A (zh) * | 2008-02-07 | 2011-03-23 | 百时美施贵宝公司 | 糖皮质激素受体、AP-1和/或NF-κB活性的稠合杂芳基调节剂及其用途 |
| EP2149552A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
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| EP2149554A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma Aktiengesellschaft | Indolylamide als Modulatoren des EP2-Rezeptors |
| EP3205648A1 (en) | 2010-06-10 | 2017-08-16 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
| DE102010027016A1 (de) | 2010-07-09 | 2012-01-12 | Universitätsklinikum Jena | Steroid-Styrylfarbstoff-Konjugate zur Simulation und direkten lichtoptischen Detektion des Verhaltens von Steroiden im lebenden biologischen Gewebe und in Gegenwart von steroidbindenden Proteinen |
| EP2791132A4 (en) | 2011-12-14 | 2015-08-05 | Seragon Pharmaceuticals Inc | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US12685719B2 (en) | 2012-07-13 | 2026-07-21 | University Of Tennessee Research Foundation | Treatment of breast cancer with selective androgen receptor modulators and cyclin-dependent kinase 4/6 inhibitors |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| EP3733170A1 (en) | 2012-07-13 | 2020-11-04 | Oncternal Therapeutics, Inc. | A method of treating androgen receptor (ar) -positive breast cancers with selective androgen receptor modulator (sarms) |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9566310B2 (en) | 2012-09-10 | 2017-02-14 | Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno | Methods of treating muscular dystrophy |
| EP2968273A4 (en) | 2013-03-15 | 2016-08-31 | Univ Nevada | METHOD FOR THE TREATMENT OF MUSCLE DYSTROPHIES |
| EP3613418A1 (en) | 2014-01-17 | 2020-02-26 | Ligand Pharmaceuticals, Inc. | Methods and compositions for modulating hormone levels |
| KR101586345B1 (ko) * | 2014-08-06 | 2016-01-18 | 한국생명공학연구원 | 에스트라디올 벤조에이트(Estradiol benzoate) 또는 이의 약학적으로 허용 가능한 염을 포함하는 근력약화 관련 질환의 예방 또는 치료용 약학적 조성물 |
| ES2927715T3 (es) | 2017-10-05 | 2022-11-10 | Fulcrum Therapeutics Inc | Inhibidores de la quinasa p38 reducen la expresión de dux4 y de los genes que le siguen para el tratamiento de la FSHD |
| US12139508B2 (en) | 2018-02-11 | 2024-11-12 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Steroid derivative regulators, method for preparing the same, and uses thereof |
| AU2020257397B2 (en) | 2019-04-19 | 2026-02-26 | Ligand Pharmaceuticals Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| WO2020263989A1 (en) | 2019-06-24 | 2020-12-30 | University Of Iowa Research Foundation | Jnk inhibitors as anticancer agents |
| WO2021023213A1 (zh) | 2019-08-07 | 2021-02-11 | 上海翰森生物医药科技有限公司 | 一种甾族类衍生物调节剂的盐及其晶型 |
| US11904006B2 (en) | 2019-12-11 | 2024-02-20 | University Of Iowa Research Foundation | Poly(diaminosulfide) particle-based vaccine |
| CN112851745B (zh) * | 2021-01-25 | 2021-11-16 | 广西民族大学 | 氮杂甾体吡啶类化合物及其合成与应用 |
| WO2022271951A1 (en) | 2021-06-23 | 2022-12-29 | University Of Iowa Research Foundation | Sustained release formulations comprising a selective androgen receptor modulator |
| CN120289552A (zh) * | 2021-07-02 | 2025-07-11 | 石家庄迪斯凯威医药科技有限公司 | 一种甾体磷酸酯化合物及其应用 |
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| US5187278A (en) | 1990-08-27 | 1993-02-16 | Merck & Co., Inc. | Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-aza-5α-androstan-3-one steroids |
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| GB9216284D0 (en) * | 1992-07-31 | 1992-09-16 | Erba Carlo Spa | Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives |
| TW408127B (en) * | 1993-09-17 | 2000-10-11 | Glaxo Inc | Androstenones |
| EP0859761A4 (en) * | 1995-09-15 | 2000-01-26 | Merck & Co Inc | 4-AZASTEROIDS FOR TREATING HYPERANDROGEN STATES |
| WO1998025623A1 (en) * | 1996-12-09 | 1998-06-18 | Merck & Co., Inc. | Methods and compositions for preventing and treating bone loss |
| NZ534946A (en) * | 2002-03-13 | 2007-05-31 | Merck & Co Inc | Fluorinated 4-azasteroid derivatives as androgen receptor modulators |
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2003
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- 2003-03-07 IL IL16382503A patent/IL163825A0/xx unknown
- 2003-03-07 JP JP2003575972A patent/JP4516316B2/ja not_active Expired - Fee Related
- 2003-03-07 HR HR20040822A patent/HRP20040822A2/hr not_active Application Discontinuation
- 2003-03-07 RU RU2004130452/04A patent/RU2320670C2/ru not_active IP Right Cessation
- 2003-03-07 CN CNA038104857A patent/CN1652786A/zh active Pending
- 2003-03-07 AU AU2003218235A patent/AU2003218235B2/en not_active Ceased
- 2003-03-07 WO PCT/US2003/008277 patent/WO2003077919A1/en not_active Ceased
- 2003-03-07 EP EP03714228A patent/EP1485095A4/en not_active Withdrawn
- 2003-03-07 PL PL03372920A patent/PL372920A1/xx not_active Application Discontinuation
- 2003-03-07 CA CA2478186A patent/CA2478186C/en not_active Expired - Fee Related
- 2003-03-07 KR KR1020047014281A patent/KR100938136B1/ko not_active Expired - Fee Related
- 2003-03-07 BR BR0308355-1A patent/BR0308355A/pt not_active IP Right Cessation
- 2003-03-07 MX MXPA04008800A patent/MXPA04008800A/es active IP Right Grant
- 2003-03-07 US US10/507,239 patent/US7186838B2/en not_active Expired - Fee Related
- 2003-07-03 UA UA20041008266A patent/UA78029C2/uk unknown
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2004
- 2004-08-26 IS IS7425A patent/IS7425A/is unknown
- 2004-08-27 ZA ZA200406843A patent/ZA200406843B/en unknown
- 2004-08-31 IL IL163825A patent/IL163825A/en not_active IP Right Cessation
- 2004-09-10 EC EC2004005287A patent/ECSP045287A/es unknown
- 2004-10-07 MA MA27893A patent/MA27112A1/fr unknown
- 2004-10-12 NO NO20044312A patent/NO20044312L/no unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| US7186838B2 (en) | 2007-03-06 |
| RU2004130452A (ru) | 2005-04-10 |
| WO2003077919A1 (en) | 2003-09-25 |
| PL372920A1 (en) | 2005-08-08 |
| IL163825A (en) | 2010-12-30 |
| JP5268975B2 (ja) | 2013-08-21 |
| MA27112A1 (fr) | 2004-12-20 |
| CN1652786A (zh) | 2005-08-10 |
| IS7425A (is) | 2004-08-26 |
| NZ534946A (en) | 2007-05-31 |
| UA78029C2 (en) | 2007-02-15 |
| NO20044312L (no) | 2004-10-12 |
| US20050165039A1 (en) | 2005-07-28 |
| KR100938136B1 (ko) | 2010-01-22 |
| JP2005526082A (ja) | 2005-09-02 |
| HRP20040822A2 (en) | 2005-06-30 |
| CA2478186C (en) | 2011-08-23 |
| ECSP045287A (es) | 2004-10-26 |
| BR0308355A (pt) | 2005-01-25 |
| JP4516316B2 (ja) | 2010-08-04 |
| ZA200406843B (en) | 2007-06-27 |
| IL163825A0 (en) | 2005-12-18 |
| CA2478186A1 (en) | 2003-09-25 |
| AU2003218235A1 (en) | 2003-09-29 |
| KR20040097167A (ko) | 2004-11-17 |
| JP2010168391A (ja) | 2010-08-05 |
| EP1485095A4 (en) | 2009-11-18 |
| EP1485095A1 (en) | 2004-12-15 |
| RU2320670C2 (ru) | 2008-03-27 |
| AU2003218235B2 (en) | 2008-05-15 |
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