MXPA04000652A - Identificacion de antigenos especificos del tumor por medio de seleccion de bibliotecas de acido desoxirribonucleico complementario con sueros y uso de antigenos en tratamiento de tumores. - Google Patents

Identificacion de antigenos especificos del tumor por medio de seleccion de bibliotecas de acido desoxirribonucleico complementario con sueros y uso de antigenos en tratamiento de tumores.

Info

Publication number
MXPA04000652A
MXPA04000652A MXPA04000652A MXPA04000652A MXPA04000652A MX PA04000652 A MXPA04000652 A MX PA04000652A MX PA04000652 A MXPA04000652 A MX PA04000652A MX PA04000652 A MXPA04000652 A MX PA04000652A MX PA04000652 A MXPA04000652 A MX PA04000652A
Authority
MX
Mexico
Prior art keywords
selection
sera
tumors
identification
treatment
Prior art date
Application number
MXPA04000652A
Other languages
English (en)
Inventor
Felici Franco
Original Assignee
Kenton S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kenton S R L filed Critical Kenton S R L
Publication of MXPA04000652A publication Critical patent/MXPA04000652A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe un metodo para la identificacion de antigenos especificos del tumor por medio de la seleccion de bibliotecas de exhibicion de CND utilizando sueros, caracterizado porque la seleccion es efectuada con la tecnica de exhibicion del fago, y en particular la seleccion es efectuada por medio de la tecnica SEREX (analisis serologico de antigenos del tumor autologo a traves de la expresion del ADNc recombinante). El metodo de acuerdo con la invencion descrito aqui combina ventajosamente el metodo SEREX con la potencia de la tecnica de exhibicion del fago definida anteriormente, al mismo tiempo que evita las desventajas caracteristicas de la tecnica SEREX. Los antigenos asi identificados son utiles para la preparacion de medicamentos para el tratamiento de tumores.
MXPA04000652A 2001-07-27 2002-07-25 Identificacion de antigenos especificos del tumor por medio de seleccion de bibliotecas de acido desoxirribonucleico complementario con sueros y uso de antigenos en tratamiento de tumores. MXPA04000652A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IT2001/000413 WO2003011902A1 (en) 2001-07-27 2001-07-27 Identification of specific tumour antigens by selection of cdna libraries with sera
PCT/IT2002/000490 WO2003011903A2 (en) 2001-07-27 2002-07-25 Identification of specific tumor antigens by means of the selection of cdna libraries with sera

Publications (1)

Publication Number Publication Date
MXPA04000652A true MXPA04000652A (es) 2004-03-19

Family

ID=11133709

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000652A MXPA04000652A (es) 2001-07-27 2002-07-25 Identificacion de antigenos especificos del tumor por medio de seleccion de bibliotecas de acido desoxirribonucleico complementario con sueros y uso de antigenos en tratamiento de tumores.

Country Status (10)

Country Link
US (1) US20050069556A1 (es)
EP (1) EP1438334A2 (es)
JP (1) JP2005508309A (es)
KR (1) KR20040049835A (es)
AU (1) AU2002330743A1 (es)
CA (1) CA2453939A1 (es)
HU (1) HUP0400661A3 (es)
MX (1) MXPA04000652A (es)
PL (1) PL369291A1 (es)
WO (2) WO2003011902A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0207251D0 (en) * 2002-03-27 2002-05-08 Isis Innovation Lymphoma-associated antigens
US20040248109A1 (en) * 2003-06-09 2004-12-09 Lawrence Greenfield Methods for selecting protein binding moieties
ITRM20040489A1 (it) 2004-10-08 2005-01-08 Sigma Tau Ind Farmaceuti Pentraxina lunga ptx3 deglicosilata o desialidata.
CN100428254C (zh) * 2006-07-20 2008-10-22 上海交通大学 交叉反应抗原计算机辅助筛选的方法
EP2108656A1 (en) 2008-03-19 2009-10-14 Beninati, Concetta Antigenic protein fragments of streptococcus pneumoniae
JP6630717B2 (ja) * 2014-07-07 2020-01-15 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 組織試料における切断ｓｎａｐ２５の検出方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002541818A (ja) * 1999-04-14 2002-12-10 ザ ガヴァメント オブ ザ ユナイテッド ステイツ オブ アメリカ、アズ レプリゼンテッド バイ ザ セクレタリー、 デパートメント オブ ヘルス アンド ヒューマン サーヴィスィズ 高感度ファージ提示生体分子検出

Also Published As

Publication number Publication date
CA2453939A1 (en) 2003-02-13
KR20040049835A (ko) 2004-06-12
HUP0400661A2 (hu) 2005-01-28
WO2003011902A1 (en) 2003-02-13
AU2002330743A1 (en) 2003-02-17
PL369291A1 (en) 2005-04-18
WO2003011903A2 (en) 2003-02-13
US20050069556A1 (en) 2005-03-31
EP1438334A2 (en) 2004-07-21
WO2003011903A3 (en) 2004-05-06
HUP0400661A3 (en) 2008-03-28
JP2005508309A (ja) 2005-03-31

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