MXPA03010328A - Acidos hidroxinamicos y acil hidroxaminasas como inhibidores de naaladasa. - Google Patents
Acidos hidroxinamicos y acil hidroxaminasas como inhibidores de naaladasa.Info
- Publication number
- MXPA03010328A MXPA03010328A MXPA03010328A MXPA03010328A MXPA03010328A MX PA03010328 A MXPA03010328 A MX PA03010328A MX PA03010328 A MXPA03010328 A MX PA03010328A MX PA03010328 A MXPA03010328 A MX PA03010328A MX PA03010328 A MXPA03010328 A MX PA03010328A
- Authority
- MX
- Mexico
- Prior art keywords
- hydroxamines
- acyl
- compounds
- hydroxamic acids
- naaladase inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Esta invencion se refiere a compuestos novedosos, composiciones farmaceuticas y equipos diagnosticos que comprenden dichos compuestos, y metodos para usar dichos compuestos para inhibir la actividad de la enzima NAALADasa, detectar enfermedades en donde los niveles de NAALADasa estan alterados, afectar la actividad neuronal, afectar la actividad del TGF-(, inhibir la angiogenesis, y tratar anormalidades del glutamato, neuropatia, dolor, trastornos compulsivos, enfermedades de la prostata, canceres y glaucoma.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29001501P | 2001-05-11 | 2001-05-11 | |
US34274101P | 2001-12-28 | 2001-12-28 | |
PCT/US2002/014635 WO2002092553A1 (en) | 2001-05-11 | 2002-05-10 | Hydroxamic acids and acyl hydroxamines as naaladase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03010328A true MXPA03010328A (es) | 2004-02-17 |
Family
ID=26965968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03010328A MXPA03010328A (es) | 2001-05-11 | 2002-05-10 | Acidos hidroxinamicos y acil hidroxaminasas como inhibidores de naaladasa. |
Country Status (7)
Country | Link |
---|---|
US (2) | US6884907B2 (es) |
EP (1) | EP1392648A1 (es) |
JP (1) | JP4625236B2 (es) |
AU (1) | AU2002256505B2 (es) |
CA (1) | CA2446740A1 (es) |
MX (1) | MXPA03010328A (es) |
WO (1) | WO2002092553A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001092273A2 (en) * | 2000-05-30 | 2001-12-06 | Guilford Pharmaceuticals Inc. | Benzenedicarboxylic acid derivatives |
AU2002256505B2 (en) * | 2001-05-11 | 2008-06-26 | Eisai Inc. | Hydroxamic acids and acyl hydroxamines as naaladase inhibitors |
US7148250B2 (en) | 2001-12-28 | 2006-12-12 | Guilford Pharmaceuticals Inc. | Indoles as NAALADase inhibitors |
JP4016667B2 (ja) * | 2002-02-15 | 2007-12-05 | ヤマハ株式会社 | 光ディスク装置、フォーカス制御方法およびプログラム |
EP1988088A1 (en) * | 2003-03-03 | 2008-11-05 | Guilford Pharmaceuticals Inc. | Thiolactones |
US20040186081A1 (en) * | 2003-03-03 | 2004-09-23 | Guilford Pharmaceuticals Inc. | Naaladase inhibitors for treating opioid tolerance |
US20060004098A1 (en) * | 2003-07-28 | 2006-01-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compounds useful for treating neurological disorders |
RU2295517C1 (ru) * | 2005-06-24 | 2007-03-20 | Институт проблем химической физики РАН (ИПХФ РАН) | Производные дикарбоновых кислот, ингибиторы метастазов и средства, повышающие химиотерапевтическую активность противоопухолевых препаратов, способ усиления эффективности цитостатиков, способ ингибирования процесса метастазирования |
EP2209498A2 (en) | 2007-10-03 | 2010-07-28 | Cornell University | Treatment of proliferative disorders using antibodies to psma |
US20140081017A1 (en) * | 2012-09-14 | 2014-03-20 | Methylgene Inc. | Histone Deacetylase Inhibitors for Enhancing Activity of Antifungal Agents |
KR102625793B1 (ko) | 2015-05-06 | 2024-01-15 | 얀센 바이오테크 인코포레이티드 | 전립선 특이적 막 항원 결합 피브로넥틴 iii형 도메인 |
US11059775B2 (en) | 2016-11-18 | 2021-07-13 | The Johns Hopkins University | Prodrug compositions and utility of hydroxamate-based GCPII inhibitors |
JP7219806B2 (ja) * | 2019-03-28 | 2023-02-08 | 富士フイルム株式会社 | 薬液、被処理物の処理方法 |
WO2021155167A1 (en) * | 2020-01-31 | 2021-08-05 | The Johns Hopkins University | Bile acid-gcpii inhibitor conjugates to treat inflammatory diseases |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3282986A (en) | 1960-10-06 | 1966-11-01 | Merck & Co Inc | N-acylated hydroxamic acids and derivatives thereof |
OA07000A (fr) * | 1981-01-23 | 1983-08-31 | Shell Internatiole Research Mi | Compositions fongicides. |
JPH0592948A (ja) * | 1991-02-06 | 1993-04-16 | Yoshitomi Pharmaceut Ind Ltd | プロピオン酸アミド誘導体およびその医薬用途 |
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
WO1994015908A1 (en) * | 1993-01-14 | 1994-07-21 | Yoshitomi Pharmaceutical Industries, Ltd. | Propionamide derivative and medicinal use thereof |
NZ288299A (en) | 1994-06-22 | 1998-06-26 | British Biotech Pharm | Substituted (hetero)aryl-sulphonylaminomethyl-hydroxamic acid and medicaments |
JP2829501B2 (ja) * | 1994-11-04 | 1998-11-25 | 参天製薬株式会社 | ヒドロキシ基を含有する新規1,3−ジアルキルウレア誘導体 |
US5962521A (en) | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
EP0911319A1 (en) | 1997-09-01 | 1999-04-28 | Roche Diagnostics GmbH | Malonic acid based matrix metalloproteinase inhibitors |
CN1298299A (zh) * | 1998-02-07 | 2001-06-06 | 英国生物技术药物有限公司 | 抗菌剂 |
US6458775B1 (en) * | 1998-07-06 | 2002-10-01 | Guilford Pharmaceutical Inc. | NAALADase inhibitors useful as pharmaceutical compounds and compositions |
US6313159B1 (en) * | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
AU2001265119A1 (en) * | 2000-05-30 | 2001-12-11 | Guilford Pharmaceuticals Inc. | Naaladase inhibitors for treating amyotrophic lateral sclerosis |
AU6661901A (en) | 2000-05-30 | 2001-12-11 | Guilford Pharm Inc | Naaladase inhibitors for treating retinal disorders and glaucoma |
WO2001092273A2 (en) | 2000-05-30 | 2001-12-06 | Guilford Pharmaceuticals Inc. | Benzenedicarboxylic acid derivatives |
AU2002256505B2 (en) * | 2001-05-11 | 2008-06-26 | Eisai Inc. | Hydroxamic acids and acyl hydroxamines as naaladase inhibitors |
-
2002
- 2002-05-10 AU AU2002256505A patent/AU2002256505B2/en not_active Ceased
- 2002-05-10 WO PCT/US2002/014635 patent/WO2002092553A1/en active Application Filing
- 2002-05-10 US US10/141,818 patent/US6884907B2/en not_active Expired - Fee Related
- 2002-05-10 MX MXPA03010328A patent/MXPA03010328A/es active IP Right Grant
- 2002-05-10 EP EP02725975A patent/EP1392648A1/en not_active Withdrawn
- 2002-05-10 CA CA002446740A patent/CA2446740A1/en not_active Abandoned
- 2002-05-10 JP JP2002589439A patent/JP4625236B2/ja not_active Expired - Fee Related
-
2005
- 2005-03-01 US US11/068,042 patent/US20060009525A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP4625236B2 (ja) | 2011-02-02 |
WO2002092553A1 (en) | 2002-11-21 |
EP1392648A1 (en) | 2004-03-03 |
AU2002256505B2 (en) | 2008-06-26 |
JP2004535398A (ja) | 2004-11-25 |
CA2446740A1 (en) | 2002-11-21 |
US20060009525A1 (en) | 2006-01-12 |
US20030087897A1 (en) | 2003-05-08 |
US6884907B2 (en) | 2005-04-26 |
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Legal Events
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