MXPA04000531A - Acilsemicarbazidas como inhibidores de cinasa dependiente de ciclina utiles como agentes anti-cancer y anti-proliferativos. - Google Patents

Acilsemicarbazidas como inhibidores de cinasa dependiente de ciclina utiles como agentes anti-cancer y anti-proliferativos.

Info

Publication number
MXPA04000531A
MXPA04000531A MXPA04000531A MXPA04000531A MXPA04000531A MX PA04000531 A MXPA04000531 A MX PA04000531A MX PA04000531 A MXPA04000531 A MX PA04000531A MX PA04000531 A MXPA04000531 A MX PA04000531A MX PA04000531 A MXPA04000531 A MX PA04000531A
Authority
MX
Mexico
Prior art keywords
cancer
cyclin dependent
acylsemicarbazides
proliferative agents
kinase inhibitors
Prior art date
Application number
MXPA04000531A
Other languages
English (en)
Inventor
Carini David
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of MXPA04000531A publication Critical patent/MXPA04000531A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invencion se refiere a la sintesis de un nuevo tipo de indeno[1,2-c]pirazol-4-onas de la formula (I) que son inhibidores potentes de la clase de enzimas que se conocen como cinasas dependientes de la ciclina, que se refieren a las subunidades cataliticas cdk1-7 y sus subunidades reguladoras conocidas como ciclinas A-G. Esta invencion tambien proporciona un metodo novedoso del tratamiento del cancer o de otras enfermedades proliferativas al administrar una cantidad terapeuticamente efectiva de uno de estos compuestos o una forma de sal farmaceuticamente aceptable del mismo. Alternativamente, se puede tratar el cancer u otras enfermedades proliferativas al administrar una combinacion terapeuticamente efectiva de uno de los compuestos de la presente invencion y uno o mas de otros agentes anticancer o antiproliferativos conocidos.
MXPA04000531A 2001-07-16 2002-07-16 Acilsemicarbazidas como inhibidores de cinasa dependiente de ciclina utiles como agentes anti-cancer y anti-proliferativos. MXPA04000531A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/906,963 US6593356B2 (en) 1999-10-20 2001-07-16 Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
PCT/US2002/022663 WO2003007883A2 (en) 2001-07-16 2002-07-16 Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents

Publications (1)

Publication Number Publication Date
MXPA04000531A true MXPA04000531A (es) 2004-05-04

Family

ID=25423309

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000531A MXPA04000531A (es) 2001-07-16 2002-07-16 Acilsemicarbazidas como inhibidores de cinasa dependiente de ciclina utiles como agentes anti-cancer y anti-proliferativos.

Country Status (15)

Country Link
US (1) US6593356B2 (es)
EP (1) EP1417177A4 (es)
JP (1) JP2004536853A (es)
KR (1) KR20040015368A (es)
CN (1) CN1553900A (es)
BR (1) BR0211203A (es)
CA (1) CA2453594A1 (es)
HU (1) HUP0401588A3 (es)
IL (1) IL159863A0 (es)
MX (1) MXPA04000531A (es)
NO (1) NO20040175L (es)
PL (1) PL366912A1 (es)
RU (1) RU2004104329A (es)
WO (1) WO2003007883A2 (es)
ZA (1) ZA200400332B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040048844A1 (en) * 1999-10-20 2004-03-11 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
JP3821090B2 (ja) * 2002-10-22 2006-09-13 トヨタ自動車株式会社 内燃機関の始動制御装置
US7456169B2 (en) 2003-02-27 2008-11-25 Abbott Laboratories Inc. Heterocyclic kinase inhibitors
US7320986B2 (en) 2003-03-07 2008-01-22 Abbott Labortories Fused tri and tetra-cyclic pyrazole kinase inhibitors
EP1740579B1 (en) 2004-03-24 2015-08-19 AbbVie Inc. Tricyclic pyrazole kinase inhibitors
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US8029441B2 (en) 2006-02-28 2011-10-04 Abbott Diabetes Care Inc. Analyte sensor transmitter unit configuration for a data monitoring and management system
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
EP3923295A1 (en) 2009-08-31 2021-12-15 Abbott Diabetes Care, Inc. Medical devices and methods
CA3134869C (en) 2010-03-24 2024-03-05 Abbott Diabetes Care Inc. Medical device inserters and processes of inserting and using medical devices
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
MX2018006250A (es) 2015-11-18 2018-09-05 Genzyme Corp Biomarcador de enfermedad poliquistica renal y usos del mismo.
GB201721185D0 (en) 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
USD1002852S1 (en) 2019-06-06 2023-10-24 Abbott Diabetes Care Inc. Analyte sensor device
USD999913S1 (en) 2020-12-21 2023-09-26 Abbott Diabetes Care Inc Analyte sensor inserter

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU767409B2 (en) 1998-04-21 2003-11-06 Du Pont Pharmaceuticals Company 5-aminoindeno(1,2-C)pyrazol-4-ones as anti-cancer and anti-proliferative agents
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
US6291504B1 (en) * 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
EP1414804A1 (en) * 2000-10-20 2004-05-06 Bristol-Myers Squibb Pharma Company Acylsemicarbazides and their use as cyclin dependent kinase (cdk) inhibitors
WO2002044174A2 (en) * 2000-12-01 2002-06-06 Bristol-Myers Squibb Pharma Company 3-(2,4-dimethylthiazol-5-yl) indeno[1,2-c]pyrazol-4-one derivatives as cdk inhibitors

Also Published As

Publication number Publication date
KR20040015368A (ko) 2004-02-18
NO20040175L (no) 2004-03-12
CN1553900A (zh) 2004-12-08
HUP0401588A2 (hu) 2005-01-28
HUP0401588A3 (en) 2005-06-28
ZA200400332B (en) 2005-06-29
EP1417177A4 (en) 2005-10-19
EP1417177A2 (en) 2004-05-12
JP2004536853A (ja) 2004-12-09
RU2004104329A (ru) 2005-07-10
CA2453594A1 (en) 2003-01-30
IL159863A0 (en) 2004-06-20
PL366912A1 (en) 2005-02-07
WO2003007883A3 (en) 2003-05-22
BR0211203A (pt) 2004-09-28
WO2003007883A2 (en) 2003-01-30
US20030073686A1 (en) 2003-04-17
US6593356B2 (en) 2003-07-15

Similar Documents

Publication Publication Date Title
IL138079A0 (en) 5-aminoindeno (1,2-c) pyrazol-4-ones as anti-cancer and anti-proliferative agents
AU6422399A (en) 6-substituted pyrazolo(3,4-d)pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
CY1107074T1 (el) Συνθεση εναντιομερων 4-αμινο-θαλιδομιδης
HK1069169A1 (en) Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors
MY134783A (en) Rho-kinase inhibitors
MY142915A (en) Rho-kinase inhibitors
WO2002044174A3 (en) 3-(2,4-dimethylthiazol-5-yl) indeno[1,2-c]pyrazol-4-one derivatives as cdk inhibitors
YU84603A (sh) Novi inhibitori tirozin kinaze
MXPA05011296A (es) Conjugados de fosfonato inhibidores de la cinasa.
TW200407311A (en) N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders
PT1678166E (pt) Inibidores de proteína-quinase
MXPA04000531A (es) Acilsemicarbazidas como inhibidores de cinasa dependiente de ciclina utiles como agentes anti-cancer y anti-proliferativos.
PL1682528T3 (pl) Pochodne benzo[b][1,4]dioksepiny
YU75603A (sh) Dihidropirimidinska jedinjenja koja su supstituisana na cijano grupi i njihova upotreba u lečenju oboljenja
WO2002079149A3 (en) Novel cyano-substituted dihydropyrimidine compounds and their use to treat diseases
BR0318521A (pt) arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados
WO2004073375A3 (en) Podophyllotoxin derivatives as antitumor agents
TW200730177A (en) 4 anilino-3-quinolinecarbonitriles for the treatment of cancer
WO2003080624A3 (en) Dithiolopyrrolone derivatives useful in the treatment of proliferative diseases