MXPA03006422A - Derivados de lactama y sultama triciclicas y sus usos como inhibidores de histona deacetilasa. - Google Patents

Derivados de lactama y sultama triciclicas y sus usos como inhibidores de histona deacetilasa.

Info

Publication number
MXPA03006422A
MXPA03006422A MXPA03006422A MXPA03006422A MXPA03006422A MX PA03006422 A MXPA03006422 A MX PA03006422A MX PA03006422 A MXPA03006422 A MX PA03006422A MX PA03006422 A MXPA03006422 A MX PA03006422A MX PA03006422 A MXPA03006422 A MX PA03006422A
Authority
MX
Mexico
Prior art keywords
histone deacetylase
deacetylase inhibitors
tricyclic lactam
sultam derivatives
sultam
Prior art date
Application number
MXPA03006422A
Other languages
English (en)
Inventor
Wolfgang Von Der Saal
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MXPA03006422A publication Critical patent/MXPA03006422A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • C07D209/92—Naphthostyrils

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
MXPA03006422A 2001-01-27 2002-01-24 Derivados de lactama y sultama triciclicas y sus usos como inhibidores de histona deacetilasa. MXPA03006422A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01101873 2001-01-27
PCT/EP2002/000705 WO2002062773A1 (en) 2001-01-27 2002-01-24 Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors

Publications (1)

Publication Number Publication Date
MXPA03006422A true MXPA03006422A (es) 2003-10-15

Family

ID=8176314

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03006422A MXPA03006422A (es) 2001-01-27 2002-01-24 Derivados de lactama y sultama triciclicas y sus usos como inhibidores de histona deacetilasa.

Country Status (15)

Country Link
US (1) US7091229B2 (es)
EP (1) EP1358168B1 (es)
JP (1) JP3961955B2 (es)
KR (1) KR100628013B1 (es)
CN (1) CN1216047C (es)
AR (1) AR035417A1 (es)
AT (1) ATE301644T1 (es)
AU (1) AU2002246053B2 (es)
BR (1) BR0206738A (es)
CA (1) CA2432196C (es)
DE (1) DE60205454T2 (es)
ES (1) ES2248531T3 (es)
MX (1) MXPA03006422A (es)
WO (1) WO2002062773A1 (es)
ZA (1) ZA200305382B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0226855D0 (en) 2002-11-18 2002-12-24 Queen Mary & Westfield College Histone deacetylase inhibitors
CA2518318A1 (en) * 2003-03-17 2004-09-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2005058298A2 (en) * 2003-12-10 2005-06-30 Wisconsin Alumni Research Foundation Fk228 analogs and their use as hdac-inhibitors
WO2005066151A2 (en) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20050159470A1 (en) * 2003-12-19 2005-07-21 Syrrx, Inc. Histone deacetylase inhibitors
EP1776357A1 (en) * 2004-08-09 2007-04-25 Astellas Pharma Inc. Hydroxyamide compounds having activity as inhibitors of histone deacetylase (hdac)
EP1824831A2 (en) * 2004-12-16 2007-08-29 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20100087328A1 (en) * 2005-03-01 2010-04-08 The Regents Of The University Of Michigan Brm expression and related diagnostics
US7604939B2 (en) * 2005-03-01 2009-10-20 The Regents Of The University Of Michigan Methods of identifying active BRM expression-promoting HDAC inhibitors
JP2008540574A (ja) * 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
CA2615105A1 (en) * 2005-07-14 2007-01-25 Takeda San Diego, Inc. Histone deacetylase inhibitors
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EP1976835A2 (en) * 2006-01-13 2008-10-08 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
AU2007249435A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 HT receptor mediated neurogenesis
ES2288803B1 (es) * 2006-07-07 2008-12-16 Universidad De Granada Derivados de benzo(d)isotiazoles como inhibidores de las histonas desacetilasas.
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
GB0620823D0 (en) 2006-10-19 2006-11-29 Univ London Histone deacetylase inhibitors
TWI519508B (zh) * 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
WO2009002941A1 (en) * 2007-06-22 2008-12-31 Board Of Regents, The University Of Texas System Composition and method for the treatment of diseases affected by histone deacetylase inhibitors
WO2009026446A2 (en) * 2007-08-21 2009-02-26 Arqule, Inc. Hdac inhibitors
US20110044952A1 (en) * 2007-11-27 2011-02-24 Ottawa Health Research Institute Amplification of cancer-specific oncolytic viral infection by histone deacetylase inhibitors
WO2009079375A1 (en) * 2007-12-14 2009-06-25 Georgetown University Histone deacetylase inhibitors
WO2010011700A2 (en) 2008-07-23 2010-01-28 The Brigham And Women's Hospital, Inc. Treatment of cancers characterized by chromosomal rearrangement of the nut gene
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
AU2010232647A1 (en) * 2009-03-31 2011-10-20 Arqule, Inc. Peri-fused pyrazolo-pyrimidine compounds
WO2015058106A1 (en) * 2013-10-18 2015-04-23 The General Hospital Corporation Imaging histone deacetylases with a radiotracer using positron emission tomography

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143791A (en) * 1994-02-03 2000-11-07 Cambridge Neuroscience, Inc. Therapeutic guanidines
AUPO721997A0 (en) 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
KR100588249B1 (ko) * 1997-12-25 2006-06-13 메이지 세이카 가부시키가이샤 테트라하이드로벤즈인돌 유도체
US6271222B1 (en) * 1998-05-28 2001-08-07 Merck & Co., Inc. Penem antibacterial compounds, compositions and methods of treatment
US6221859B1 (en) * 1999-08-27 2001-04-24 Merck & Co., Inc. Carbapenem antibacterial compositions and methods of the treatment

Also Published As

Publication number Publication date
ES2248531T3 (es) 2006-03-16
DE60205454T2 (de) 2006-03-30
KR100628013B1 (ko) 2006-09-26
CN1216047C (zh) 2005-08-24
US7091229B2 (en) 2006-08-15
KR20030072607A (ko) 2003-09-15
JP2004517956A (ja) 2004-06-17
ZA200305382B (en) 2004-10-11
JP3961955B2 (ja) 2007-08-22
EP1358168B1 (en) 2005-08-10
DE60205454D1 (de) 2005-09-15
CA2432196C (en) 2007-11-27
ATE301644T1 (de) 2005-08-15
AU2002246053B2 (en) 2005-02-17
CN1487925A (zh) 2004-04-07
EP1358168A1 (en) 2003-11-05
BR0206738A (pt) 2004-02-03
WO2002062773A1 (en) 2002-08-15
US20040077698A1 (en) 2004-04-22
CA2432196A1 (en) 2002-08-15
AR035417A1 (es) 2004-05-26

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