MXPA03003199A - 3,4-dihidro-pirimido?11,2-a]pirimidinas y 3,4-dihidro-pirazino[1,2-a?3 pirimidinas sustituidas. - Google Patents

3,4-dihidro-pirimido?11,2-a]pirimidinas y 3,4-dihidro-pirazino[1,2-a?3 pirimidinas sustituidas.

Info

Publication number
MXPA03003199A
MXPA03003199A MXPA03003199A MXPA03003199A MXPA03003199A MX PA03003199 A MXPA03003199 A MX PA03003199A MX PA03003199 A MXPA03003199 A MX PA03003199A MX PA03003199 A MXPA03003199 A MX PA03003199A MX PA03003199 A MXPA03003199 A MX PA03003199A
Authority
MX
Mexico
Prior art keywords
pyrimidines
dihydro
compounds
pyrimido
substituted
Prior art date
Application number
MXPA03003199A
Other languages
English (en)
Inventor
Matthias Gerlach
Original Assignee
Gr Nenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gr Nenthal Gmbh filed Critical Gr Nenthal Gmbh
Publication of MXPA03003199A publication Critical patent/MXPA03003199A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invencion se refiere a 3,4-dihidro-pirimido [1, 2-a]pirimidinas y 3,4-dihidro-pirazino [1,2-a]pirimidinas sustituidas de estructura general (I), a metodos para su produccion, a bibliotecas de sustancias que los contienen, a medicamentos que contienen estos compuestos, al uso de estos compuestos para la elaboracion de medicamentos para el tratamiento de dolores, incontinencia urinaria, comezon, tinnitus aurium y/o diarrea, asi como a preparaciones que contienen estos compuestos.
MXPA03003199A 2000-10-13 2001-10-10 3,4-dihidro-pirimido?11,2-a]pirimidinas y 3,4-dihidro-pirazino[1,2-a?3 pirimidinas sustituidas. MXPA03003199A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10050661A DE10050661A1 (de) 2000-10-13 2000-10-13 Substituierte 3,4-Dihydro-pyrimido[1,2-a]pyrimidine und 3,4-Dihydro-pyrazino[1,2-a]pyrimidine
PCT/EP2001/011702 WO2002030934A1 (de) 2000-10-13 2001-10-10 Substituierte 3,4-dihydro-pyrimido[1,2-a]pyrimidine und 3,4-dihydropyrazino[1,2-a]pyrimidine

Publications (1)

Publication Number Publication Date
MXPA03003199A true MXPA03003199A (es) 2004-03-18

Family

ID=7659596

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03003199A MXPA03003199A (es) 2000-10-13 2001-10-10 3,4-dihidro-pirimido?11,2-a]pirimidinas y 3,4-dihidro-pirazino[1,2-a?3 pirimidinas sustituidas.

Country Status (26)

Country Link
US (1) US7226924B2 (es)
EP (1) EP1325010B1 (es)
JP (1) JP2004511485A (es)
KR (1) KR20030036923A (es)
CN (1) CN1243753C (es)
AR (1) AR035496A1 (es)
AT (1) ATE294180T1 (es)
AU (1) AU2002214007A1 (es)
BR (1) BR0114735A (es)
CA (1) CA2425685A1 (es)
DE (2) DE10050661A1 (es)
EC (1) ECSP034554A (es)
ES (1) ES2239168T3 (es)
HK (1) HK1056558A1 (es)
HU (1) HUP0302606A3 (es)
IL (1) IL155379A0 (es)
MX (1) MXPA03003199A (es)
NO (1) NO20031588D0 (es)
NZ (1) NZ525651A (es)
PE (1) PE20020477A1 (es)
PL (1) PL361777A1 (es)
PT (1) PT1325010E (es)
RU (1) RU2003113965A (es)
SK (1) SK4152003A3 (es)
WO (1) WO2002030934A1 (es)
ZA (1) ZA200303634B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006065703A1 (en) 2004-12-13 2006-06-22 Sunesis Pharmaceuticals, Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558618A (en) * 1968-04-01 1971-01-26 Dow Chemical Co Novel 4h-pyrazino(1,2-a)pyrimidine-4-ones
GB1347493A (en) * 1971-02-11 1974-02-27 Aspro Nicholas Ltd Benzazine derivatives
HU178910B (en) * 1977-08-19 1982-07-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 2,3-disubstituted-4-oxo-4h-pyrido/1,2-a/-pyrimidines
JP2668259B2 (ja) * 1988-02-18 1997-10-27 塩野義製薬株式会社 複素環化合物および抗潰瘍剤
FI94531C (fi) * 1990-03-13 1995-09-25 Ime Intermed Enterpris Sa Menetelmä farmaseuttisesti aktiivisen 1,3,4,6,7,8-heksahydro-2H-pyrimido-(1,2-a)-pyrimidiinijohdannaisen valmistamiseksi
IT1263804B (it) * 1993-01-22 1996-09-03 Luso Farmaco Inst Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista
KR100260292B1 (ko) * 1995-09-28 2000-07-01 오쓰카 요시미쓰 진통제

Also Published As

Publication number Publication date
AU2002214007A1 (en) 2002-04-22
BR0114735A (pt) 2003-10-14
PE20020477A1 (es) 2002-06-29
CN1243753C (zh) 2006-03-01
HUP0302606A2 (hu) 2004-07-28
NO20031588L (no) 2003-04-08
EP1325010B1 (de) 2005-04-27
SK4152003A3 (en) 2003-10-07
ES2239168T3 (es) 2005-09-16
PL361777A1 (en) 2004-10-04
DE50106048D1 (de) 2005-06-02
PT1325010E (pt) 2005-08-31
HUP0302606A3 (en) 2007-03-28
AR035496A1 (es) 2004-06-02
KR20030036923A (ko) 2003-05-09
JP2004511485A (ja) 2004-04-15
ECSP034554A (es) 2003-05-26
US20030220322A1 (en) 2003-11-27
RU2003113965A (ru) 2004-12-10
EP1325010A1 (de) 2003-07-09
HK1056558A1 (en) 2004-02-20
NO20031588D0 (no) 2003-04-08
ATE294180T1 (de) 2005-05-15
CA2425685A1 (en) 2003-04-11
DE10050661A1 (de) 2002-04-18
NZ525651A (en) 2004-10-29
ZA200303634B (en) 2004-08-12
IL155379A0 (en) 2003-11-23
US7226924B2 (en) 2007-06-05
CN1469879A (zh) 2004-01-21
WO2002030934A1 (de) 2002-04-18

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