MXPA03000315A - 1-(4-aminofenil) indoles sustituidos y su uso como agentes anti-inflamatorios. - Google Patents

1-(4-aminofenil) indoles sustituidos y su uso como agentes anti-inflamatorios.

Info

Publication number
MXPA03000315A
MXPA03000315A MXPA03000315A MXPA03000315A MXPA03000315A MX PA03000315 A MXPA03000315 A MX PA03000315A MX PA03000315 A MXPA03000315 A MX PA03000315A MX PA03000315 A MXPA03000315 A MX PA03000315A MX PA03000315 A MXPA03000315 A MX PA03000315A
Authority
MX
Mexico
Prior art keywords
indoles
aminophenyl
substituted
inflammatory agents
lymphocytes
Prior art date
Application number
MXPA03000315A
Other languages
English (en)
Inventor
Rajiv Sharma
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MXPA03000315A publication Critical patent/MXPA03000315A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invencion se refiere a 1-(4- aminofenil)indoles opcionalmente sustituidos en las posiciones 2, 4, 5, 6 y 7 del anillo indol y en el grupo amino en la posicion 4 del anillo fenilo, los indoles que inhiben la produccion de IL-2 en los linfocitos T.
MXPA03000315A 2000-07-13 2001-07-09 1-(4-aminofenil) indoles sustituidos y su uso como agentes anti-inflamatorios. MXPA03000315A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/616,014 US6353007B1 (en) 2000-07-13 2000-07-13 Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents
PCT/US2001/021670 WO2002006273A1 (en) 2000-07-13 2001-07-09 Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
MXPA03000315A true MXPA03000315A (es) 2003-06-06

Family

ID=24467698

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03000315A MXPA03000315A (es) 2000-07-13 2001-07-09 1-(4-aminofenil) indoles sustituidos y su uso como agentes anti-inflamatorios.

Country Status (6)

Country Link
US (1) US6353007B1 (es)
EP (1) EP1303508A1 (es)
JP (1) JP2004504318A (es)
CA (1) CA2415126A1 (es)
MX (1) MXPA03000315A (es)
WO (1) WO2002006273A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099206A2 (en) * 2002-05-21 2003-12-04 Bristol-Myers Squibb Company Indole compounds useful as impdh inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
KR20070028553A (ko) * 2004-06-18 2007-03-12 바이올리폭스 에이비 염증 치료에 유용한 인돌
EP1765775B1 (en) * 2004-06-18 2009-04-29 Biolipox AB Indoles useful in the treatment of inflammation
CA2570531A1 (en) * 2004-06-18 2005-12-29 Kristofer Olofsson Indoles useful in the treatment of inflammation
CA2594773A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
CA2594878A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
JP2008527030A (ja) * 2005-01-19 2008-07-24 バイオリポックス エービー 炎症の治療に有用なインドール類
CA2594665A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Thienopyrroles useful in the treatment of inflammation
KR20070114123A (ko) * 2005-01-19 2007-11-29 바이올리폭스 에이비 염증 치료에 유용한 인돌
WO2006077401A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Pyrrolopyridines useful in the treatment of inflammation
AR056690A1 (es) * 2005-10-14 2007-10-17 Athersys Inc Derivados de indol como inhibidores de indol como inhibidores del receptor 3 de histamina para el tartamiento de trastornos del sueno y cognitivos obesidad y otros trastornos de snc
EP2350006A1 (en) * 2008-10-01 2011-08-03 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
TW201038553A (en) * 2009-03-19 2010-11-01 Sanofi Aventis Novel indazole derivatives which inhibit HSP90, compositions containing them and use thereof
US9550750B2 (en) * 2012-10-05 2017-01-24 Merck Sharp & Dohme Corp. Indoline compounds as aldosterone synthase inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598596A (en) * 1968-07-22 1971-08-10 Eastman Kodak Co Direct positive silver halide emulsions containing sensitizing dye with a 1,2-diaryl substituted indole nucleus
FR2215216A1 (en) * 1973-01-22 1974-08-23 Delalande Sa Alpha-amino indol-3-ylacetic acids - with antiinflammatory, analgesic, antidepressant and sedative activity
FR2260332A1 (en) * 1974-02-12 1975-09-05 Delalande Sa 1-Phenyl-2-aminocarbonyl-indoles - with respiratory analeptic, antiinflammatory analgesic, vasodilator, diuretic and anti-ulcer activity
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
CA1324320C (en) * 1988-03-31 1993-11-16 Thomas M. Schultz Use of n-substituted-5,6-dihydroxyindoles as a hair coloring agent
TW229140B (es) * 1992-06-05 1994-09-01 Shell Internat Res Schappej B V
US5880037A (en) * 1992-09-08 1999-03-09 Applied Materials, Inc. Oxide etch process using a mixture of a fluorine-substituted hydrocarbon and acetylene that provides high selectivity to nitride and is suitable for use on surfaces of uneven topography
FR2751966B1 (fr) * 1996-08-01 1998-10-30 Union Pharma Scient Appl Nouveaux derives 1,2-diarylindoles, leurs procedes de preparation, et leurs utilisations en therapeutique
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
AU3387999A (en) * 1998-04-08 1999-10-25 Abbott Laboratories Pyrazole inhibitors of cytokine production

Also Published As

Publication number Publication date
US6353007B1 (en) 2002-03-05
EP1303508A1 (en) 2003-04-23
JP2004504318A (ja) 2004-02-12
WO2002006273A1 (en) 2002-01-24
CA2415126A1 (en) 2002-01-24

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Legal Events

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