MXPA02008365A - Mutantes de proteinas moreogeneticas del hueso. - Google Patents

Mutantes de proteinas moreogeneticas del hueso.

Info

Publication number
MXPA02008365A
MXPA02008365A MXPA02008365A MXPA02008365A MXPA02008365A MX PA02008365 A MXPA02008365 A MX PA02008365A MX PA02008365 A MXPA02008365 A MX PA02008365A MX PA02008365 A MXPA02008365 A MX PA02008365A MX PA02008365 A MXPA02008365 A MX PA02008365A
Authority
MX
Mexico
Prior art keywords
mutants
present
relates
bone morphogenetic
morphogenetic proteins
Prior art date
Application number
MXPA02008365A
Other languages
English (en)
Inventor
Franz Weber
Original Assignee
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich filed Critical Univ Zuerich
Publication of MXPA02008365A publication Critical patent/MXPA02008365A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invencion se refiere a novedosos mutantes de proteinas morfogeneticas del hueso (BMP) utiles como inhibidores de osificacion heterotopica; especificamente, la presente invencion se refiere a novedosos mutantes que contienen solamente la region completa implicada en la formacion del dedo 2 que incluye el epitope de muneca de una BMP con un resido de cisteina especifico o residuos de cisteina especificos reemplazados por un aminoacido diferente; la presente invencion tambien se refiere a composiciones farmaceuticas que contienen estos mutantes y al uso de los mutantes y composiciones farmaceuticas en terapia.
MXPA02008365A 2001-08-24 2002-08-26 Mutantes de proteinas moreogeneticas del hueso. MXPA02008365A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20011705A FI116827B (fi) 2001-08-24 2001-08-24 Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö

Publications (1)

Publication Number Publication Date
MXPA02008365A true MXPA02008365A (es) 2004-08-12

Family

ID=8561791

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02008365A MXPA02008365A (es) 2001-08-24 2002-08-26 Mutantes de proteinas moreogeneticas del hueso.

Country Status (5)

Country Link
US (2) US7186689B2 (es)
EP (1) EP1298140A3 (es)
CA (1) CA2394973A1 (es)
FI (1) FI116827B (es)
MX (1) MXPA02008365A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI116827B (fi) * 2001-08-24 2006-03-15 Univ Zuerich Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1074620A1 (en) 1999-08-06 2001-02-07 HyGene AG Monomeric protein of the TGF-beta family
JPH11335398A (ja) 1998-05-22 1999-12-07 Hoechst Marion Roussel Kk 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬
AU778998B2 (en) 1998-09-22 2004-12-23 University Of Maryland At Baltimore Cystine knot growth factor mutants
AU1103900A (en) 1998-10-07 2000-04-26 Stryker Corporation Modified tgf-beta superfamily proteins
FI117667B (fi) 2001-07-05 2007-01-15 Univ Zuerich Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä
FI116827B (fi) * 2001-08-24 2006-03-15 Univ Zuerich Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö

Also Published As

Publication number Publication date
EP1298140A3 (en) 2003-04-16
FI20011705A (fi) 2003-02-25
US7186689B2 (en) 2007-03-06
US20030073633A1 (en) 2003-04-17
EP1298140A2 (en) 2003-04-02
FI116827B (fi) 2006-03-15
FI20011705A0 (fi) 2001-08-24
CA2394973A1 (en) 2003-02-24
US20060270602A1 (en) 2006-11-30
US7378395B2 (en) 2008-05-27

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