MXPA02008247A - Conjugado de polisacarido-polipeptido. - Google Patents

Conjugado de polisacarido-polipeptido.

Info

Publication number
MXPA02008247A
MXPA02008247A MXPA02008247A MXPA02008247A MXPA02008247A MX PA02008247 A MXPA02008247 A MX PA02008247A MX PA02008247 A MXPA02008247 A MX PA02008247A MX PA02008247 A MXPA02008247 A MX PA02008247A MX PA02008247 A MXPA02008247 A MX PA02008247A
Authority
MX
Mexico
Prior art keywords
polypeptide
polysaccharide
polypeptide conjugate
amino group
free amino
Prior art date
Application number
MXPA02008247A
Other languages
English (en)
Inventor
Helmut Eckert
Original Assignee
Igeneon Krebs Immuntherapie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igeneon Krebs Immuntherapie filed Critical Igeneon Krebs Immuntherapie
Publication of MXPA02008247A publication Critical patent/MXPA02008247A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

La invencion describe un metodo para la produccion de un conjugado de polisacarido-polipeptido al hacer reaccionar un polisacarido con un polipeptido que comprende al menos un grupo amino libre. Un portador de polisacarido que tiene grupos hidroxi adyacentes, se oxida en el polipeptido por lo cual el anillo se abre a fin de crear los grupos aldehidos adyacentes y se hace reaccionar con uno o mas polipeptido(s) de antigeno labil(es) a las bases contienen al menos un grupo amino libre, el polipeptido(s) que se enlaza directamente al portador de polisacarido con al menos un enlace de azometino.
MXPA02008247A 2000-03-21 2001-03-21 Conjugado de polisacarido-polipeptido. MXPA02008247A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT4712000 2000-03-21
PCT/AT2001/000079 WO2001070272A1 (de) 2000-03-21 2001-03-21 Polysaccharid-polypeptid konjugat

Publications (1)

Publication Number Publication Date
MXPA02008247A true MXPA02008247A (es) 2004-04-05

Family

ID=3674758

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02008247A MXPA02008247A (es) 2000-03-21 2001-03-21 Conjugado de polisacarido-polipeptido.

Country Status (10)

Country Link
EP (1) EP1267937B1 (es)
AT (1) ATE429251T1 (es)
AU (1) AU2001242084A1 (es)
CA (1) CA2404111C (es)
DE (1) DE50114852D1 (es)
DK (1) DK1267937T3 (es)
ES (1) ES2325528T3 (es)
MX (1) MXPA02008247A (es)
SI (1) SI1267937T1 (es)
WO (1) WO2001070272A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
AT502293B1 (de) * 2002-05-15 2008-03-15 Igeneon Krebs Immuntherapie Immunogener, monoklonaler antikörper
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
WO2005044861A1 (en) * 2003-10-31 2005-05-19 Wyeth Holdings Corporation Polysaccharides of helicobacter pylori
JP5396019B2 (ja) * 2004-03-11 2014-01-22 フレゼニウス・カビ・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ヒドロキシアルキルデンプンとタンパク質とのコンジュゲート
DE102006035899A1 (de) 2006-07-31 2008-02-07 Dade Behring Marburg Gmbh Polysacharid-Peptid-Konjugate zur Verwendung als Thrombinsubstrate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU730694A1 (ru) * 1976-07-05 1980-04-30 Всесоюзный Научно-Исследовательский Технологический Институт Антибиотиков И Ферментов Медицинского Назначения Модифицированный террилитином декстран, обладающий фибринолитической активностью
WO1996020012A2 (en) * 1994-12-23 1996-07-04 Middlesex Sciences, Inc. Methods for preparing and purifying macromolecular conjugates
US6011008A (en) * 1997-01-08 2000-01-04 Yissum Research Developement Company Of The Hebrew University Of Jerusalem Conjugates of biologically active substances
CA2233725A1 (en) * 1998-03-31 1999-09-30 Hemosol Inc. Hemoglobin-hydroxyethyl starch complexes

Also Published As

Publication number Publication date
DE50114852D1 (de) 2009-06-04
AU2001242084A1 (en) 2001-10-03
DK1267937T3 (da) 2009-08-03
EP1267937B1 (de) 2009-04-22
SI1267937T1 (sl) 2009-10-31
WO2001070272A1 (de) 2001-09-27
ES2325528T3 (es) 2009-09-08
EP1267937A1 (de) 2003-01-02
ATE429251T1 (de) 2009-05-15
CA2404111C (en) 2010-05-25
CA2404111A1 (en) 2002-09-19

Similar Documents

Publication Publication Date Title
EP1553975B8 (en) Optimized fc variants and methods for their generation
WO2001070685A3 (en) Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
AU2002358799A1 (en) Improved structured-functional bonding matrices for biomolecules
HUP0402192A2 (hu) EGF receptor elleni antitesteket tartalmazó liofilizált készítmény
DE60036930D1 (de) Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen
MXPA04004814A (es) Metodos para descubrir ligandos.
ATE369878T1 (de) Träger-pharmaka-konjugate
ES547495A0 (es) Procedimiento para la produccion de anticuerpos monoclonales a ciclosporinas.
AU2002355677A1 (en) Antigenic polypeptides
NZ337202A (en) Method for providing enhanced photosynthesis for horticultural crops by applying highly reflective particulate materials
NZ590690A (en) Antibodies that bind to p-selectin glycoprotein ligand 1
EP1176195A4 (en) METHOD FOR CONTROLLING THE ACTIVITY OF IMMUNOLOGICALLY FUNCTIONAL MOLECULE
SI0870014T1 (sl) Aldolazno katalitično protitelo
AU9742698A (en) Amino acid sequences for therapeutical and prophylactic applications to diseasesdue to (clostridium difficile) toxins
WO2000056901A3 (en) Linear and circular expression elements
CA2348026A1 (en) Antibodies against semp1, methods for their production and uses thereof
MXPA02008247A (es) Conjugado de polisacarido-polipeptido.
EP2058334A3 (en) Monoclonal antibodies, cross-reactive antibodies and method for producing the same
AU4304696A (en) Process for preparing aliphatic alpha,omega-aminonitriles
AU1278801A (en) Method for generating information related to the molecular structure of a biomolecule
AU5489498A (en) Non-aggregated fluorescent conjugates and method for obtaining them
AU2003232481A1 (en) Ferrocenyl ligands and method for the production of such ligands
AU5045493A (en) Process for preparing conjugates consisting of a specific binding partner and a carbohydrate-containing protein
AU2001250429A1 (en) Method for producing 2-alkyl-3-chlorophenols
PT1064265E (pt) Sintese de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo e acetona

Legal Events

Date Code Title Description
GB Transfer or rights
FG Grant or registration