MX9804766A - Process for making dihydropyrimidinones. - Google Patents
Process for making dihydropyrimidinones.Info
- Publication number
- MX9804766A MX9804766A MX9804766A MX9804766A MX9804766A MX 9804766 A MX9804766 A MX 9804766A MX 9804766 A MX9804766 A MX 9804766A MX 9804766 A MX9804766 A MX 9804766A MX 9804766 A MX9804766 A MX 9804766A
- Authority
- MX
- Mexico
- Prior art keywords
- dihydropyrimidinones
- alkyl
- making
- cu2o
- diketone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Catalysts (AREA)
Abstract
The present invention provides a process for forming 5-(alkyl or alkoxy)carbonyl-6-alkyl-4-(aryl or alkyl)-3,4-2(1H)-dihydropyrimidinones by combining a 'beta'-keto ester or diketone, an aldehyde and urea in the presence of a boron reagent, a metal salt (e.g., Cu2O) and a catalyst (e.g., acid). The reaction is typically run in one pot in a solvent to afford dihydropyrimidinones in higher yields and with easier work up than previously known methods.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US008641 | 1993-01-25 | ||
US864195P | 1995-12-14 | 1995-12-14 | |
GBGB9617968.4A GB9617968D0 (en) | 1996-08-28 | 1996-08-28 | Process for making dihydropyrimidinones |
GB9617968.4 | 1996-08-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX9804766A true MX9804766A (en) | 1998-10-31 |
MXPA98004766A MXPA98004766A (en) | 1999-01-11 |
Family
ID=
Also Published As
Publication number | Publication date |
---|---|
JP2000501734A (en) | 2000-02-15 |
NZ326039A (en) | 1999-08-30 |
CA2238924A1 (en) | 1997-06-19 |
EP0882026A4 (en) | 1999-04-07 |
WO1997021687A1 (en) | 1997-06-19 |
SK77398A3 (en) | 1999-02-11 |
KR19990072125A (en) | 1999-09-27 |
CZ184098A3 (en) | 1998-11-11 |
PL327147A1 (en) | 1998-11-23 |
EP0882026A1 (en) | 1998-12-09 |
BR9611933A (en) | 1999-03-02 |
AU1331697A (en) | 1997-07-03 |
AU705409B2 (en) | 1999-05-20 |
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