MX9804766A - Process for making dihydropyrimidinones. - Google Patents

Process for making dihydropyrimidinones.

Info

Publication number
MX9804766A
MX9804766A MX9804766A MX9804766A MX9804766A MX 9804766 A MX9804766 A MX 9804766A MX 9804766 A MX9804766 A MX 9804766A MX 9804766 A MX9804766 A MX 9804766A MX 9804766 A MX9804766 A MX 9804766A
Authority
MX
Mexico
Prior art keywords
dihydropyrimidinones
alkyl
making
cu2o
diketone
Prior art date
Application number
MX9804766A
Other languages
Spanish (es)
Other versions
MXPA98004766A (en
Inventor
Essa H Hu
Daniel R Sidler
Ulf H Dolling
Michael A Patane
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617968.4A external-priority patent/GB9617968D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX9804766A publication Critical patent/MX9804766A/en
Publication of MXPA98004766A publication Critical patent/MXPA98004766A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Catalysts (AREA)

Abstract

The present invention provides a process for forming 5-(alkyl or alkoxy)carbonyl-6-alkyl-4-(aryl or alkyl)-3,4-2(1H)-dihydropyrimidinones by combining a 'beta'-keto ester or diketone, an aldehyde and urea in the presence of a boron reagent, a metal salt (e.g., Cu2O) and a catalyst (e.g., acid). The reaction is typically run in one pot in a solvent to afford dihydropyrimidinones in higher yields and with easier work up than previously known methods.
MXPA/A/1998/004766A 1995-12-14 1998-06-12 Procedure to make dihydropyrimidine MXPA98004766A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US008641 1993-01-25
US864195P 1995-12-14 1995-12-14
GBGB9617968.4A GB9617968D0 (en) 1996-08-28 1996-08-28 Process for making dihydropyrimidinones
GB9617968.4 1996-08-28

Publications (2)

Publication Number Publication Date
MX9804766A true MX9804766A (en) 1998-10-31
MXPA98004766A MXPA98004766A (en) 1999-01-11

Family

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Also Published As

Publication number Publication date
JP2000501734A (en) 2000-02-15
NZ326039A (en) 1999-08-30
CA2238924A1 (en) 1997-06-19
EP0882026A4 (en) 1999-04-07
WO1997021687A1 (en) 1997-06-19
SK77398A3 (en) 1999-02-11
KR19990072125A (en) 1999-09-27
CZ184098A3 (en) 1998-11-11
PL327147A1 (en) 1998-11-23
EP0882026A1 (en) 1998-12-09
BR9611933A (en) 1999-03-02
AU1331697A (en) 1997-07-03
AU705409B2 (en) 1999-05-20

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