MX9802103A - Nuevos imidazoles inhibidores de la lipoxigenasa, composiciones que los contienen y uso de los mismos. - Google Patents

Nuevos imidazoles inhibidores de la lipoxigenasa, composiciones que los contienen y uso de los mismos.

Info

Publication number
MX9802103A
MX9802103A MX9802103A MX9802103A MX9802103A MX 9802103 A MX9802103 A MX 9802103A MX 9802103 A MX9802103 A MX 9802103A MX 9802103 A MX9802103 A MX 9802103A MX 9802103 A MX9802103 A MX 9802103A
Authority
MX
Mexico
Prior art keywords
halo
alkyl
substituted
alkoxy
alkylthio
Prior art date
Application number
MX9802103A
Other languages
English (en)
Other versions
MXPA98002103A (es
Inventor
Takashi Mano
Rodney W Stevens
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX9802103A publication Critical patent/MX9802103A/es
Publication of MXPA98002103A publication Critical patent/MXPA98002103A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion aporta un compuesto de formula (I): y una sal farmacéuticamente aceptable, en la que Ar es fenilo sustituido opcionalmente con halo, hidroxi, ciano, amino, alquilo C1-C4, alcoxilo C1-C4, tioalquilo C1-C4, alquilo C1-C4 halosustituido o alcoxilo C1-C4 halosustituido; X es -A-X1- o -X1-A-, en la que A es un enlace directo o alquileno C1-C4, y X1 es oxi, tio, sulfinilo o sulfonilo; Ar1 es fenileno, piridileno o tienileno sustituido opcionalmente con halo, hidroxilo, ciano, nitro, amino, alquilo C1-C4, alcoxilo C1-C4, tioalquilo C1-C4, alquilo C1-C4 halosustituido, alcoxilo C1-C4 halosustituido, alquilamino C1-C4 dialquilamino C1-C4; Y es CN o CONR1R2 en la que R1 y R2 son de forma independiente hidrogeno o alquilo C1-C4, y R es hidrogeno o alquilo C1-C4; R es hidrogeno o alquilo C1-C6; W es alquileno C2-C3, del cual un átomo de carbono podría estar sustituido por un átomo de oxígeno; además la invencion aporta una composicion farmacéutica para el tratamiento de una enfermedad inflamatoria, alergia o enfermedades cardiovasculares o similares en un mamífero que comprende un compuesto de formula I y un vehículo farmacéuticamente aceptable; y el uso del compuesto en la preparacion de dicha composicion.
MXPA/A/1998/002103A 1995-09-18 1998-03-17 Nuevos imidazoles inhibidores de la lipoxigenasa,composiciones que los contienen y uso de los mismos MXPA98002103A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCPCT/IB1995/000767 1995-09-18
IB9500767 1995-09-18

Publications (2)

Publication Number Publication Date
MX9802103A true MX9802103A (es) 1998-08-30
MXPA98002103A MXPA98002103A (es) 1998-11-12

Family

ID=

Also Published As

Publication number Publication date
EP0863905B1 (en) 2000-11-29
CA2232267A1 (en) 1997-03-27
ES2152539T3 (es) 2001-02-01
US6037355A (en) 2000-03-14
GR3035279T3 (en) 2001-04-30
CA2232267C (en) 2002-06-11
WO1997011079A1 (en) 1997-03-27
DK0863905T3 (da) 2001-01-02
DE69611101T2 (de) 2001-04-05
JPH10511115A (ja) 1998-10-27
JP3110049B2 (ja) 2000-11-20
EP0863905A1 (en) 1998-09-16
PT863905E (pt) 2001-03-30
ATE197796T1 (de) 2000-12-15
DE69611101D1 (de) 2001-01-04

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