MX9802103A - Nuevos imidazoles inhibidores de la lipoxigenasa, composiciones que los contienen y uso de los mismos. - Google Patents
Nuevos imidazoles inhibidores de la lipoxigenasa, composiciones que los contienen y uso de los mismos.Info
- Publication number
- MX9802103A MX9802103A MX9802103A MX9802103A MX9802103A MX 9802103 A MX9802103 A MX 9802103A MX 9802103 A MX9802103 A MX 9802103A MX 9802103 A MX9802103 A MX 9802103A MX 9802103 A MX9802103 A MX 9802103A
- Authority
- MX
- Mexico
- Prior art keywords
- halo
- alkyl
- substituted
- alkoxy
- alkylthio
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion aporta un compuesto de formula (I): y una sal farmacéuticamente aceptable, en la que Ar es fenilo sustituido opcionalmente con halo, hidroxi, ciano, amino, alquilo C1-C4, alcoxilo C1-C4, tioalquilo C1-C4, alquilo C1-C4 halosustituido o alcoxilo C1-C4 halosustituido; X es -A-X1- o -X1-A-, en la que A es un enlace directo o alquileno C1-C4, y X1 es oxi, tio, sulfinilo o sulfonilo; Ar1 es fenileno, piridileno o tienileno sustituido opcionalmente con halo, hidroxilo, ciano, nitro, amino, alquilo C1-C4, alcoxilo C1-C4, tioalquilo C1-C4, alquilo C1-C4 halosustituido, alcoxilo C1-C4 halosustituido, alquilamino C1-C4 dialquilamino C1-C4; Y es CN o CONR1R2 en la que R1 y R2 son de forma independiente hidrogeno o alquilo C1-C4, y R es hidrogeno o alquilo C1-C4; R es hidrogeno o alquilo C1-C6; W es alquileno C2-C3, del cual un átomo de carbono podría estar sustituido por un átomo de oxígeno; además la invencion aporta una composicion farmacéutica para el tratamiento de una enfermedad inflamatoria, alergia o enfermedades cardiovasculares o similares en un mamífero que comprende un compuesto de formula I y un vehículo farmacéuticamente aceptable; y el uso del compuesto en la preparacion de dicha composicion.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCPCT/IB1995/000767 | 1995-09-18 | ||
| IB9500767 | 1995-09-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9802103A true MX9802103A (es) | 1998-08-30 |
| MXPA98002103A MXPA98002103A (es) | 1998-11-12 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| EP0863905B1 (en) | 2000-11-29 |
| CA2232267A1 (en) | 1997-03-27 |
| ES2152539T3 (es) | 2001-02-01 |
| US6037355A (en) | 2000-03-14 |
| GR3035279T3 (en) | 2001-04-30 |
| CA2232267C (en) | 2002-06-11 |
| WO1997011079A1 (en) | 1997-03-27 |
| DK0863905T3 (da) | 2001-01-02 |
| DE69611101T2 (de) | 2001-04-05 |
| JPH10511115A (ja) | 1998-10-27 |
| JP3110049B2 (ja) | 2000-11-20 |
| EP0863905A1 (en) | 1998-09-16 |
| PT863905E (pt) | 2001-03-30 |
| ATE197796T1 (de) | 2000-12-15 |
| DE69611101D1 (de) | 2001-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |