ES2152539T3 - Imidazoles inhibidores de la lipoxigenasa. - Google Patents
Imidazoles inhibidores de la lipoxigenasa.Info
- Publication number
- ES2152539T3 ES2152539T3 ES96923010T ES96923010T ES2152539T3 ES 2152539 T3 ES2152539 T3 ES 2152539T3 ES 96923010 T ES96923010 T ES 96923010T ES 96923010 T ES96923010 T ES 96923010T ES 2152539 T3 ES2152539 T3 ES 2152539T3
- Authority
- ES
- Spain
- Prior art keywords
- halo
- alkyl
- pct
- substituted
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION PROPONE UN COMPUESTO DE FORMULA (I) Y UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE AR ES FENILENO OPCIONALMENTE SUSTITUIDO CON HALO, HIDROXI, CIANO, AMINO, ALQUILO C 1 - C 4 , ALCOXI C 1 - C 4 , A LQUILTIO C 1 - C 4 , HALOALQUILO C 1 - C 4 O HALOALCOXI C 1 - C 4 ; X ES - A - X 1 - O - X SUP,1 - A -, DONDE A ES UN ENLACE DIRECTO O UN ALQUILENO C SUB,1 - C 4 , Y X 1 ES OXI, TIO, SULFINILO O SULFONILO; AR 1 ES FENILENO, PIRIDILENO O TIENILENO OPCIONALMENTE SUSTITUIDO CON HALO, HIDROXI, CIANO, NITRO, AMINO, ALQUILO C SUB,1 - C 4 , ALCOXI C 1 - C 4 , ALQUILTIO C 1 - C 4 , HALOALQUILO C 1 - C 4 , HALOALCOXI C SUB,1 - C 4 , ALQUILAMINO C 1 - C 4 O DI(ALQUIL C SUB,1 C 4 )AMINO; Y ES CN O CONR 1 R 2 DONDE R SUP,1 Y R 2 SON INDEPENDIENTEMENTE HIDROGENO O ALQUILO C SUB,1 C 4 ; Y R ES HIDROGENO O ALQUILO C 1 - C 6; W ES ALQUILENO C 2 - C 3 , UNO DE CUYOS ATOMOS DE CARBONO PUEDE SER REEMPLAZADO POR UN ATOMO DE OXIGENO. LA INVENCION PROPONE ADEMAS UNA COMPOSICION FARMACEUTICA PARA TRATAR ENFERMEDADES INFLAMATORIAS, ALERGIAS O ENFERMEDADES CARDIOVASCULARES O SIMILARES EN MAMIFEROS QUE INCLUYE UN COMPUESTO DE FORMULA (I) Y UN PORTADOR FARMACEUTICAMENTE ACEPTABLE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB9500767 | 1995-09-18 | ||
PCT/IB1996/000744 WO1997011079A1 (en) | 1995-09-18 | 1996-07-24 | Novel imidazole lipoxygenase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2152539T3 true ES2152539T3 (es) | 2001-02-01 |
Family
ID=11004367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96923010T Expired - Lifetime ES2152539T3 (es) | 1995-09-18 | 1996-07-24 | Imidazoles inhibidores de la lipoxigenasa. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6037355A (es) |
EP (1) | EP0863905B1 (es) |
JP (1) | JP3110049B2 (es) |
AT (1) | ATE197796T1 (es) |
CA (1) | CA2232267C (es) |
DE (1) | DE69611101T2 (es) |
DK (1) | DK0863905T3 (es) |
ES (1) | ES2152539T3 (es) |
GR (1) | GR3035279T3 (es) |
PT (1) | PT863905E (es) |
WO (1) | WO1997011079A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6344563B1 (en) * | 1999-08-31 | 2002-02-05 | Timothy Norris | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems |
MX2009005526A (es) | 2006-11-27 | 2009-06-05 | Pfizer Prod Inc | Analogos de pirazol. |
EP3083577A4 (en) * | 2013-12-19 | 2017-08-16 | Archer Daniels Midland Co. | Sulfonates of furan-2,5-dimethanol and (tetrahydrofuran-2,5-diyl)dimethanol and derivatives thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE911853A1 (en) * | 1990-06-21 | 1992-01-01 | Ici Plc | Heterocyclene derivatives |
EP0462830B1 (en) * | 1990-06-21 | 1995-10-18 | Zeneca Limited | Cyclic ether derivatives |
JPH09504775A (ja) * | 1993-06-02 | 1997-05-13 | ゼネカ・リミテッド | 二環式エーテル誘導体および5−リポキシゲナーゼ阻害物質としてのそれらの使用 |
RU2126004C1 (ru) * | 1993-06-14 | 1999-02-10 | Пфайзер, Инк. | Производные имидазола или их фармацевтически приемлемые соли |
US5459271A (en) * | 1993-07-20 | 1995-10-17 | Merck Frosst Canada, Inc. | Arylbicyclooctanes as inhibitors of leukotriene biosynthesis |
-
1996
- 1996-07-24 CA CA002232267A patent/CA2232267C/en not_active Expired - Fee Related
- 1996-07-24 US US09/043,256 patent/US6037355A/en not_active Expired - Fee Related
- 1996-07-24 EP EP96923010A patent/EP0863905B1/en not_active Expired - Lifetime
- 1996-07-24 DE DE69611101T patent/DE69611101T2/de not_active Expired - Fee Related
- 1996-07-24 DK DK96923010T patent/DK0863905T3/da active
- 1996-07-24 PT PT96923010T patent/PT863905E/pt unknown
- 1996-07-24 JP JP09512513A patent/JP3110049B2/ja not_active Expired - Fee Related
- 1996-07-24 AT AT96923010T patent/ATE197796T1/de not_active IP Right Cessation
- 1996-07-24 WO PCT/IB1996/000744 patent/WO1997011079A1/en active IP Right Grant
- 1996-07-24 ES ES96923010T patent/ES2152539T3/es not_active Expired - Lifetime
-
2001
- 2001-01-22 GR GR20010400096T patent/GR3035279T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0863905B1 (en) | 2000-11-29 |
DE69611101D1 (de) | 2001-01-04 |
PT863905E (pt) | 2001-03-30 |
MX9802103A (es) | 1998-08-30 |
DK0863905T3 (da) | 2001-01-02 |
JP3110049B2 (ja) | 2000-11-20 |
ATE197796T1 (de) | 2000-12-15 |
DE69611101T2 (de) | 2001-04-05 |
CA2232267C (en) | 2002-06-11 |
EP0863905A1 (en) | 1998-09-16 |
WO1997011079A1 (en) | 1997-03-27 |
US6037355A (en) | 2000-03-14 |
CA2232267A1 (en) | 1997-03-27 |
GR3035279T3 (en) | 2001-04-30 |
JPH10511115A (ja) | 1998-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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