MX9710389A - Antagonistas del receptor de vitronectina, su preparacion y empleo del mismo. - Google Patents

Antagonistas del receptor de vitronectina, su preparacion y empleo del mismo.

Info

Publication number
MX9710389A
MX9710389A MX9710389A MX9710389A MX9710389A MX 9710389 A MX9710389 A MX 9710389A MX 9710389 A MX9710389 A MX 9710389A MX 9710389 A MX9710389 A MX 9710389A MX 9710389 A MX9710389 A MX 9710389A
Authority
MX
Mexico
Prior art keywords
antagonists
preparation
vitronectine
receiver
same
Prior art date
Application number
MX9710389A
Other languages
English (en)
Other versions
MXPA97010389A (es
Inventor
Volkmar Wehner
Hans Ulrich Stilz
Anuschirwan Peyman
Karlheinz Scheunemann
Jean-Marie Ruxer
Denis Carniato
Jean-Michel Lefrancois
Thomas Richard Garek
Robert Mcdowell
Original Assignee
Hoechst Ag
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag, Genentech Inc filed Critical Hoechst Ag
Publication of MX9710389A publication Critical patent/MX9710389A/es
Publication of MXPA97010389A publication Critical patent/MXPA97010389A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los antagonistas del receptor de vitronectina, cuya preparacion y empleo son objeto de la presente invencion, son compuestos de formula I A-B-D-E-F-G en la que A, B, D, E, F Y G tienen los significados que se indican en las reivindicaciones de la patente, su preparacion y su empleo como medicamento. Los compuestos segun la invencion se emplean como antagonistas del receptor de vitronectina y como inhibidores de la absorcion osea.
MXPA/A/1997/010389A 1996-12-20 1997-12-18 Antagonistas del receptor de vitronectina, su preparacion y empleo del mismo MXPA97010389A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19653645A DE19653645A1 (de) 1996-12-20 1996-12-20 Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19653645.6 1996-12-20

Publications (2)

Publication Number Publication Date
MX9710389A true MX9710389A (es) 1998-08-30
MXPA97010389A MXPA97010389A (es) 1998-11-12

Family

ID=

Also Published As

Publication number Publication date
JPH10182617A (ja) 1998-07-07
NO975975L (no) 1998-06-22
ID19245A (id) 1998-06-28
CA2225267A1 (en) 1998-06-20
AR010369A1 (es) 2000-06-07
TR199701645A3 (tr) 1998-07-21
ZA9711315B (en) 1998-06-22
EP0854145A3 (de) 2000-03-22
KR19980064419A (ko) 1998-10-07
EP0854145A2 (de) 1998-07-22
IL122643A0 (en) 1998-08-16
NO975975D0 (no) 1997-12-19
TR199701645A2 (xx) 1998-07-21
PL323968A1 (en) 1998-06-22
CN1200373A (zh) 1998-12-02
DE19653645A1 (de) 1998-06-25
AU729760B2 (en) 2001-02-08
HU9702509D0 (en) 1998-03-02
HUP9702509A3 (en) 2001-04-28
HUP9702509A2 (hu) 1999-06-28
NZ329429A (en) 1999-05-28
AU4846497A (en) 1998-06-25
CZ411297A3 (cs) 1998-07-15
BR9706386A (pt) 2003-04-22
US5990145A (en) 1999-11-23

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