MX9710258A - Biflavanoides y derivados de los mismos como agentes antivirales. - Google Patents

Biflavanoides y derivados de los mismos como agentes antivirales.

Info

Publication number
MX9710258A
MX9710258A MX9710258A MX9710258A MX9710258A MX 9710258 A MX9710258 A MX 9710258A MX 9710258 A MX9710258 A MX 9710258A MX 9710258 A MX9710258 A MX 9710258A MX 9710258 A MX9710258 A MX 9710258A
Authority
MX
Mexico
Prior art keywords
derivatives
robustaflavone
biflavanoids
antiviral
hsv
Prior art date
Application number
MX9710258A
Other languages
English (en)
Inventor
Yuh-Meei Lin
Michael T Flavin
Ralph Schure
David E Zembower
Geng-Xian Zhao
Original Assignee
Medichem Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Res Inc filed Critical Medichem Res Inc
Publication of MX9710258A publication Critical patent/MX9710258A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporcionan biflavonoides antivirarles sustancialmente purificados: robustaflavona, hinokiflavona, amentoflavona, agatisflavona, volkensiflavona, morelloflavona, rhusflavona, succedaneaflavona, GB-1a y GB-2a. También se describen derivados fiflavonoides antivirales y formas de sales de los mismos, por ejemplo, sal de potasio de tetrasulfato de robustaflavona, así como métodos para preparar los mismos. También se proporcionan composiciones farmacéuticas las cuales incluyen biflavanoides antivirales, derivados o sales de los mismos. También se describe un método mejorado para obtener robustaflavona sustancialmente pura a partir de material vegetal. Los compuestos biflavanoides, derivados o sales de los mismos de la invencion pueden ser utilizados en un método para tratar y/o prevenir infecciones virales provocadas por agentes virales tales como influenza, por ejemplo, influenza A y B; hepatitis, por ejemplo hepatitis B, virus de inmunodeficiencia humana, por ejemplo VIH-1; virus herpes (HSV-1 y HSV-2); virus de Varicella Zoster (VZV); y sarampion.
MX9710258A 1995-06-23 1996-06-21 Biflavanoides y derivados de los mismos como agentes antivirales. MX9710258A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46595P 1995-06-23 1995-06-23
PCT/US1996/010718 WO1997000679A1 (en) 1995-06-23 1996-06-21 Biflavanoids and derivatives thereof as antiviral agents

Publications (1)

Publication Number Publication Date
MX9710258A true MX9710258A (es) 1998-08-30

Family

ID=21691631

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9710258A MX9710258A (es) 1995-06-23 1996-06-21 Biflavanoides y derivados de los mismos como agentes antivirales.

Country Status (9)

Country Link
US (2) US5773462A (es)
EP (1) EP0833631B1 (es)
JP (1) JPH11508264A (es)
AT (1) ATE227569T1 (es)
AU (1) AU707798B2 (es)
CA (1) CA2225341A1 (es)
DE (1) DE69624813T2 (es)
MX (1) MX9710258A (es)
WO (1) WO1997000679A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0833631B1 (en) * 1995-06-23 2002-11-13 Advanced Life Sciences Inc. Robustaflavone and derivatives thereof as antiviral agents
FR2755015B1 (fr) * 1996-10-25 1998-12-24 Sod Conseils Rech Applic Utilisation d'un extrait flavonoidique de ginkgo biloba substantiellement depourvu de terpenes, dans le domaine buccodentaire, et composition contenant un tel extrait
WO1998046238A1 (en) * 1997-04-15 1998-10-22 Medichem Research, Inc. Biflavinoids and derivatives thereof as antiviral agents, alone or in combination with at least one known antiviral agent
AU5663000A (en) * 1999-06-30 2001-01-22 Radak Systems Pty Ltd A spraying apparatus
US6677350B1 (en) 1999-09-22 2004-01-13 Advanced Life Sciences, Inc. Beta-fluoroethyl thiourea compounds and use
US6548241B1 (en) 2000-11-28 2003-04-15 Gambro, Inc. Storage solution containing photosensitizer for inactivation of biological contaminants
KR20030037081A (ko) 2001-11-02 2003-05-12 한국과학기술연구원 Ｔ 타입 칼슘채널을 조절하여 복통을 억제하는 방법
AU2003207116A1 (en) * 2003-02-25 2004-09-17 The Kitasato Institute Anti-influenza virus compound comprising biflavonoid-sialic acid glycoside
KR100647722B1 (ko) * 2004-02-18 2006-11-23 주식회사 바이오텍 아이 감기 예방용 조성물
EP1781628A2 (en) * 2004-08-26 2007-05-09 Wyeth a Corporation of the State of Delaware Prodrug substituted benzoxazoles as estrogenic agents
US20090264342A1 (en) * 2006-02-13 2009-10-22 Trustees Of Boston University Compositions and methods for antibiotic potentiation and drug discovery
US20100234348A1 (en) * 2006-08-04 2010-09-16 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
US8314143B2 (en) * 2006-12-29 2012-11-20 Florida A&M University Synthetic flavonoids and pharmaceutical compositions and therapeutic methods of treatment of HIV infection and other pathologies
CN102026970B (zh) * 2007-11-21 2013-07-31 解码遗传Ehf公司 用于治疗肺部和心血管病症的联芳基pde4抑制剂
CN102695703A (zh) * 2009-08-19 2012-09-26 自由州大学 C-3偶合的双类黄酮和c-3偶合的双类黄酮类似物的合成
US9119814B2 (en) 2009-10-14 2015-09-01 Woongjin Coway Co., Ltd. Composition for prevention of influenza viral infection comprising sumac extract, air filter comprising the same and air cleaning device comprising the filter
US20140348966A1 (en) * 2011-12-22 2014-11-27 Onesmo B. Balemba Garcinia buchananii baker compounds, compositions and related methods
CN107311973B (zh) * 2017-06-25 2021-04-06 石家庄学院 一种含硝酸酯基二氢杨梅素衍生物及其制备和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3544457A1 (de) * 1985-12-16 1987-06-19 Mape Establishment Arzneimittel zur behandlung von leberkrankheiten
JPS62200570A (ja) * 1986-02-27 1987-09-04 Fuji Photo Film Co Ltd 磁気記録再生装置
JPS6442426A (en) * 1987-08-11 1989-02-14 Daicel Chem Virus-genom inactivator
GB8728236D0 (en) * 1987-12-02 1988-01-06 Sandoz Ltd Improvements in/relating to fungicides
JPH01221314A (ja) * 1988-02-29 1989-09-04 Daicel Chem Ind Ltd ウイルス・ゲノム不活化剤
US5354866A (en) * 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
IT1239281B (it) * 1989-10-27 1993-10-19 Indena Spa Composizioni per la riduzione dei depositi di grasso superfluo a base di principi attivi di origine vegetale ad attivita' agonista dell'adenilato ciclasi o/e ad attivita' antifosfodiesterasica
EP0833631B1 (en) * 1995-06-23 2002-11-13 Advanced Life Sciences Inc. Robustaflavone and derivatives thereof as antiviral agents

Also Published As

Publication number Publication date
AU707798B2 (en) 1999-07-22
ATE227569T1 (de) 2002-11-15
DE69624813D1 (de) 2002-12-19
US5773462A (en) 1998-06-30
CA2225341A1 (en) 1997-01-09
US5948918A (en) 1999-09-07
JPH11508264A (ja) 1999-07-21
EP0833631A1 (en) 1998-04-08
WO1997000679A1 (en) 1997-01-09
DE69624813T2 (de) 2003-09-11
AU6288096A (en) 1997-01-22
EP0833631B1 (en) 2002-11-13

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: ADVANCED LIFE SCIENCES, INC.

MM Annulment or lapse due to non-payment of fees