MX9710258A - Biflavanoides y derivados de los mismos como agentes antivirales. - Google Patents
Biflavanoides y derivados de los mismos como agentes antivirales.Info
- Publication number
- MX9710258A MX9710258A MX9710258A MX9710258A MX9710258A MX 9710258 A MX9710258 A MX 9710258A MX 9710258 A MX9710258 A MX 9710258A MX 9710258 A MX9710258 A MX 9710258A MX 9710258 A MX9710258 A MX 9710258A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- robustaflavone
- biflavanoids
- antiviral
- hsv
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se proporcionan biflavonoides antivirarles sustancialmente purificados: robustaflavona, hinokiflavona, amentoflavona, agatisflavona, volkensiflavona, morelloflavona, rhusflavona, succedaneaflavona, GB-1a y GB-2a. También se describen derivados fiflavonoides antivirales y formas de sales de los mismos, por ejemplo, sal de potasio de tetrasulfato de robustaflavona, así como métodos para preparar los mismos. También se proporcionan composiciones farmacéuticas las cuales incluyen biflavanoides antivirales, derivados o sales de los mismos. También se describe un método mejorado para obtener robustaflavona sustancialmente pura a partir de material vegetal. Los compuestos biflavanoides, derivados o sales de los mismos de la invencion pueden ser utilizados en un método para tratar y/o prevenir infecciones virales provocadas por agentes virales tales como influenza, por ejemplo, influenza A y B; hepatitis, por ejemplo hepatitis B, virus de inmunodeficiencia humana, por ejemplo VIH-1; virus herpes (HSV-1 y HSV-2); virus de Varicella Zoster (VZV); y sarampion.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46595P | 1995-06-23 | 1995-06-23 | |
PCT/US1996/010718 WO1997000679A1 (en) | 1995-06-23 | 1996-06-21 | Biflavanoids and derivatives thereof as antiviral agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9710258A true MX9710258A (es) | 1998-08-30 |
Family
ID=21691631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9710258A MX9710258A (es) | 1995-06-23 | 1996-06-21 | Biflavanoides y derivados de los mismos como agentes antivirales. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5773462A (es) |
EP (1) | EP0833631B1 (es) |
JP (1) | JPH11508264A (es) |
AT (1) | ATE227569T1 (es) |
AU (1) | AU707798B2 (es) |
CA (1) | CA2225341A1 (es) |
DE (1) | DE69624813T2 (es) |
MX (1) | MX9710258A (es) |
WO (1) | WO1997000679A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9710258A (es) * | 1995-06-23 | 1998-08-30 | Medichem Res Inc | Biflavanoides y derivados de los mismos como agentes antivirales. |
FR2755015B1 (fr) * | 1996-10-25 | 1998-12-24 | Sod Conseils Rech Applic | Utilisation d'un extrait flavonoidique de ginkgo biloba substantiellement depourvu de terpenes, dans le domaine buccodentaire, et composition contenant un tel extrait |
WO1998046238A1 (en) * | 1997-04-15 | 1998-10-22 | Medichem Research, Inc. | Biflavinoids and derivatives thereof as antiviral agents, alone or in combination with at least one known antiviral agent |
AU5663000A (en) * | 1999-06-30 | 2001-01-22 | Radak Systems Pty Ltd | A spraying apparatus |
US6677350B1 (en) | 1999-09-22 | 2004-01-13 | Advanced Life Sciences, Inc. | Beta-fluoroethyl thiourea compounds and use |
US6548241B1 (en) | 2000-11-28 | 2003-04-15 | Gambro, Inc. | Storage solution containing photosensitizer for inactivation of biological contaminants |
KR20030037081A (ko) | 2001-11-02 | 2003-05-12 | 한국과학기술연구원 | T 타입 칼슘채널을 조절하여 복통을 억제하는 방법 |
US20070004649A1 (en) * | 2003-02-25 | 2007-01-04 | The Kitasato Institute | Anti-influenza virus compound comprising biflavonoid-sialic acid glycoside |
KR100647722B1 (ko) * | 2004-02-18 | 2006-11-23 | 주식회사 바이오텍 아이 | 감기 예방용 조성물 |
AU2005280178A1 (en) * | 2004-08-26 | 2006-03-09 | Wyeth | Prodrug substituted benzoxazoles as estrogenic agents |
WO2007095187A2 (en) * | 2006-02-13 | 2007-08-23 | Trustees Of Boston University | Compositions and methods for antibiotic potentiation and drug discovery |
US20100234348A1 (en) * | 2006-08-04 | 2010-09-16 | Trustees Of Boston University | Compositions and methods for potentiating antibiotic activity |
US8314143B2 (en) * | 2006-12-29 | 2012-11-20 | Florida A&M University | Synthetic flavonoids and pharmaceutical compositions and therapeutic methods of treatment of HIV infection and other pathologies |
CA2722611A1 (en) * | 2007-11-21 | 2009-05-28 | Decode Genetics Ehf | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders |
CN102695703A (zh) * | 2009-08-19 | 2012-09-26 | 自由州大学 | C-3偶合的双类黄酮和c-3偶合的双类黄酮类似物的合成 |
US9119814B2 (en) * | 2009-10-14 | 2015-09-01 | Woongjin Coway Co., Ltd. | Composition for prevention of influenza viral infection comprising sumac extract, air filter comprising the same and air cleaning device comprising the filter |
US20140348966A1 (en) * | 2011-12-22 | 2014-11-27 | Onesmo B. Balemba | Garcinia buchananii baker compounds, compositions and related methods |
CN107311973B (zh) * | 2017-06-25 | 2021-04-06 | 石家庄学院 | 一种含硝酸酯基二氢杨梅素衍生物及其制备和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3544457A1 (de) * | 1985-12-16 | 1987-06-19 | Mape Establishment | Arzneimittel zur behandlung von leberkrankheiten |
JPS62200570A (ja) * | 1986-02-27 | 1987-09-04 | Fuji Photo Film Co Ltd | 磁気記録再生装置 |
JPS6442426A (en) * | 1987-08-11 | 1989-02-14 | Daicel Chem | Virus-genom inactivator |
GB8728236D0 (en) * | 1987-12-02 | 1988-01-06 | Sandoz Ltd | Improvements in/relating to fungicides |
JPH01221314A (ja) * | 1988-02-29 | 1989-09-04 | Daicel Chem Ind Ltd | ウイルス・ゲノム不活化剤 |
US5354866A (en) * | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
IT1239281B (it) * | 1989-10-27 | 1993-10-19 | Indena Spa | Composizioni per la riduzione dei depositi di grasso superfluo a base di principi attivi di origine vegetale ad attivita' agonista dell'adenilato ciclasi o/e ad attivita' antifosfodiesterasica |
MX9710258A (es) * | 1995-06-23 | 1998-08-30 | Medichem Res Inc | Biflavanoides y derivados de los mismos como agentes antivirales. |
-
1996
- 1996-06-21 MX MX9710258A patent/MX9710258A/es not_active IP Right Cessation
- 1996-06-21 US US08/668,284 patent/US5773462A/en not_active Expired - Fee Related
- 1996-06-21 DE DE69624813T patent/DE69624813T2/de not_active Expired - Fee Related
- 1996-06-21 JP JP9503972A patent/JPH11508264A/ja not_active Ceased
- 1996-06-21 AU AU62880/96A patent/AU707798B2/en not_active Ceased
- 1996-06-21 CA CA002225341A patent/CA2225341A1/en not_active Abandoned
- 1996-06-21 WO PCT/US1996/010718 patent/WO1997000679A1/en active IP Right Grant
- 1996-06-21 AT AT96921740T patent/ATE227569T1/de not_active IP Right Cessation
- 1996-06-21 EP EP96921740A patent/EP0833631B1/en not_active Expired - Lifetime
-
1998
- 1998-04-14 US US09/059,913 patent/US5948918A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU707798B2 (en) | 1999-07-22 |
EP0833631A1 (en) | 1998-04-08 |
US5773462A (en) | 1998-06-30 |
ATE227569T1 (de) | 2002-11-15 |
DE69624813T2 (de) | 2003-09-11 |
JPH11508264A (ja) | 1999-07-21 |
AU6288096A (en) | 1997-01-22 |
EP0833631B1 (en) | 2002-11-13 |
WO1997000679A1 (en) | 1997-01-09 |
CA2225341A1 (en) | 1997-01-09 |
US5948918A (en) | 1999-09-07 |
DE69624813D1 (de) | 2002-12-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
PD | Change of proprietorship |
Owner name: ADVANCED LIFE SCIENCES, INC. |
|
MM | Annulment or lapse due to non-payment of fees |