MX9709125A - Metodo para preparar ureas ciclicas n,n'-disustituidas. - Google Patents

Metodo para preparar ureas ciclicas n,n'-disustituidas.

Info

Publication number
MX9709125A
MX9709125A MX9709125A MX9709125A MX9709125A MX 9709125 A MX9709125 A MX 9709125A MX 9709125 A MX9709125 A MX 9709125A MX 9709125 A MX9709125 A MX 9709125A MX 9709125 A MX9709125 A MX 9709125A
Authority
MX
Mexico
Prior art keywords
cyclic ureas
disubstitued
preparing
cho
iii
Prior art date
Application number
MX9709125A
Other languages
English (en)
Inventor
Thomas Edgar Smyser
Pasquale Nicholas Confalone
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of MX9709125A publication Critical patent/MX9709125A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion se refiere a ureas cíclicas disustituidas de la Formula IV, las cuales se preparan por la alquilacion reductiva de un compuesto de la Formula I con aldehídos R22-CHO o R23CHO en presencia de un agente reductor, para formar el compuesto de la formula II (Etapa 1), segundo por una ciclocarbonilacion del compuesto de la Formula II, para obtener el compuesto de la Formula III (Etapa 2) y por la desproteccion del compuesto de la Formula III para formar el diol de la Formula IV (Etapa 3), de conformidad con el Esquema anterior. Estas ureas cíclicas de la Formula IV son utiles como inhibidores de proteasa de VIH.
MX9709125A 1995-06-06 1996-06-04 Metodo para preparar ureas ciclicas n,n'-disustituidas. MX9709125A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/469,409 US5532356A (en) 1995-06-06 1995-06-06 Method for preparing N,N'-disubstituted cyclic ureas
PCT/US1996/008556 WO1996039393A1 (en) 1995-06-06 1996-06-04 Method for preparing n, n'-disubstitued cyclic ureas

Publications (1)

Publication Number Publication Date
MX9709125A true MX9709125A (es) 1998-03-31

Family

ID=23863677

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9709125A MX9709125A (es) 1995-06-06 1996-06-04 Metodo para preparar ureas ciclicas n,n'-disustituidas.

Country Status (20)

Country Link
US (1) US5532356A (es)
EP (1) EP0830349B1 (es)
JP (1) JPH11506765A (es)
AR (1) AR002385A1 (es)
AT (1) ATE190974T1 (es)
AU (1) AU700805B2 (es)
CA (1) CA2222132A1 (es)
DE (1) DE69607344T2 (es)
DK (1) DK0830349T3 (es)
ES (1) ES2145452T3 (es)
GR (1) GR3033199T3 (es)
HR (1) HRP960258B1 (es)
IL (1) IL122457A0 (es)
MX (1) MX9709125A (es)
MY (1) MY113863A (es)
NZ (1) NZ309557A (es)
PT (1) PT830349E (es)
TW (1) TW355707B (es)
WO (1) WO1996039393A1 (es)
ZA (1) ZA964749B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466797A (en) * 1994-06-30 1995-11-14 The Du Pont Merck Pharmaceutical Company Intermediates for the preparation of cyclic urea
US5532357A (en) * 1995-06-07 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas
US6054597A (en) * 1995-11-14 2000-04-25 Dupont Pharmaceuticals Processes and intermediates for the preparation of cyclic urea HIV protease inhibitors
EP0973767A1 (en) * 1997-03-31 2000-01-26 Dupont Pharmaceuticals Company Indazoles of cyclic ureas useful as hiv protease inhibitors
US6218534B1 (en) 1997-10-06 2001-04-17 Dupont Pharmaceuticals Company Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate
US6313110B1 (en) * 1999-06-02 2001-11-06 Dupont Pharmaceuticals Company Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor
US7104279B2 (en) * 2000-05-30 2006-09-12 Red Valve Co., Inc. Method and apparatus for preventing stagnation in fluid reservoirs
FR2810039B1 (fr) * 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation
NZ547696A (en) 2003-12-23 2009-12-24 Astex Therapeutics Ltd Pyrazole derivatives as protein kinase modulators
EP1902032A1 (en) * 2005-06-22 2008-03-26 Astex Therapeutics Limited Pharmaceutical compounds
EP1933832A2 (en) 2005-06-23 2008-06-25 Astex Therapeutics Limited Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators
US7777030B2 (en) * 2005-12-29 2010-08-17 Centre National de la Recherge Scientifique (CNRS) Compositions and methods for the treatment and prevention of disease
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
KR101663255B1 (ko) * 2015-11-30 2016-10-10 주식회사 삼양사 안정성이 향상된 농축 무수당 알코올 제조용 조성물 및 무수당 알코올의 농축 방법
KR101663264B1 (ko) * 2015-11-30 2016-10-10 주식회사 삼양사 저장 안정성이 향상된 무수당 알코올 조성물 및 무수당 알코올의 저장 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100268694B1 (ko) * 1991-10-11 2000-10-16 미리암 디. 메코너헤이, 블레어큐. 퍼거슨 레트로바이러스 프로테아제 억제제로 유용한 시클릭 우레아 및 유사체
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors

Also Published As

Publication number Publication date
CA2222132A1 (en) 1996-12-12
DK0830349T3 (da) 2000-07-17
IL122457A0 (en) 1998-06-15
DE69607344D1 (de) 2000-04-27
ZA964749B (en) 1997-12-08
AR002385A1 (es) 1998-03-11
GR3033199T3 (en) 2000-08-31
HRP960258B1 (en) 2000-12-31
EP0830349B1 (en) 2000-03-22
ES2145452T3 (es) 2000-07-01
DE69607344T2 (de) 2000-09-21
US5532356A (en) 1996-07-02
AU5975296A (en) 1996-12-24
PT830349E (pt) 2000-08-31
ATE190974T1 (de) 2000-04-15
NZ309557A (en) 2001-06-29
JPH11506765A (ja) 1999-06-15
TW355707B (en) 1999-04-11
MY113863A (en) 2002-06-29
WO1996039393A1 (en) 1996-12-12
EP0830349A1 (en) 1998-03-25
HRP960258A2 (en) 1997-12-31
AU700805B2 (en) 1999-01-14

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