MX9708822A - Tribencimidazoles utiles como inhibidores de topoisomerasa i. - Google Patents
Tribencimidazoles utiles como inhibidores de topoisomerasa i.Info
- Publication number
- MX9708822A MX9708822A MX9708822A MX9708822A MX9708822A MX 9708822 A MX9708822 A MX 9708822A MX 9708822 A MX9708822 A MX 9708822A MX 9708822 A MX9708822 A MX 9708822A MX 9708822 A MX9708822 A MX 9708822A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- inhibitors
- topoisomerase
- tribenzimidazoles
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion provee inhibidores de topoisomerasa I anti-neoplásticos de la formula (I), en donde Ar es arilo (C2-C12) o heteroarilo (de 5 a 12 miembros) que comprende 1-3 de N, S u O sin peroxido, en donde N está no substituido o substituido con alquilo (C1-C4); X es H, CN, CHO, OH, acetilo, CF3, O-alquilo (C1-C4), NO2, NH2, halogeno o halogeno-alquilo (C1-C4); cada Y es individualmente H. alquilo o aralquilo (C1-C4); Y' es H o alquilo (C1-C4); n es 0 o 1; y cada Z es individualmente H, alquilo (C1-C4), halogeno o halogeno alquilo (C1-C4); o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08442657 | 1995-05-17 | ||
| US08/442,657 US5807874A (en) | 1995-05-17 | 1995-05-17 | Trisbenzimidazoles useful as topoisomerase I inhibitors |
| US08/618,988 US5767142A (en) | 1996-03-20 | 1996-03-20 | Trisbenzimidazoles useful as topoisomerase I inhibitors |
| US08618988 | 1996-03-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9708822A true MX9708822A (es) | 1998-06-30 |
| MXPA97008822A MXPA97008822A (es) | 1998-10-30 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| PL324034A1 (en) | 1998-05-11 |
| AU5746696A (en) | 1996-11-29 |
| EP0839140A1 (en) | 1998-05-06 |
| HUP9900071A3 (en) | 2002-01-28 |
| NZ307959A (en) | 1998-08-26 |
| BR9608476A (pt) | 1999-08-17 |
| CA2221248A1 (en) | 1996-11-21 |
| CZ363197A3 (cs) | 1998-05-13 |
| HUP9900071A2 (hu) | 2000-03-28 |
| WO1996036612A1 (en) | 1996-11-21 |
| JPH11508229A (ja) | 1999-07-21 |
| AU713317B2 (en) | 1999-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |