MX9703989A - Procedimientos e intermediarios para preparar cis(+)3-[4, 5-dihidroxicroman-3-ilmetil]-4-metoxianilina. - Google Patents

Procedimientos e intermediarios para preparar cis(+)3-[4, 5-dihidroxicroman-3-ilmetil]-4-metoxianilina.

Info

Publication number
MX9703989A
MX9703989A MX9703989A MX9703989A MX9703989A MX 9703989 A MX9703989 A MX 9703989A MX 9703989 A MX9703989 A MX 9703989A MX 9703989 A MX9703989 A MX 9703989A MX 9703989 A MX9703989 A MX 9703989A
Authority
MX
Mexico
Prior art keywords
formula
compounds
optionally substituted
dihydroxychroman
methoxyaniline
Prior art date
Application number
MX9703989A
Other languages
English (en)
Other versions
MXPA97003989A (es
Inventor
George J Quallich
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX9703989A publication Critical patent/MX9703989A/es
Publication of MXPA97003989A publication Critical patent/MXPA97003989A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Esta invencion se refiere a un procedimiento para preparar el compuesto de formula II que comprende tratar el compuesto de formula II que comprende tratar el compuesto de formula IIIA, en donde YH es (R)-CSA o L-DTTA, con hidrogeno en presencia de un catalizador de metal precioso, preferiblemente Pd(OH)2; los compuestos de formula II son utiles en la preparacion de compuestos de formula I en donde Ar es un heteroarilo de 5 a 8 miembros opcionalmente substituidos o anillo de heteroarilo opcionalmente substituido fusionado con benceno opcionalmente substituido en donde dicho anillo de heteroarilo comprende de 1 a 4 heteroátomos seleccionados de nitrogeno, oxígeno y azufre, los cuales son utiles para inhibir la produccion de leucotrieno y/o bloquear a los receptores de leucotrieno y en la prevencion o tratamiento de asma, artritis, psoriasis, ulceras, infarto al miocardio y estados patologicos relacionados en mamíferos; la invencion también se refiere a compuestos de las formulas (IVA); (IVB); (IIIC); (IIIB) y (IIID).
MXPA/A/1997/003989A 1994-11-30 1995-10-06 Procedimientos e intermediarios para preparar cis(+)3-[4, 6-dihidroxicroman-3-ilmetil]-4-metoxianilina MXPA97003989A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08346955 1994-11-30
US08/346,955 US5539128A (en) 1994-11-30 1994-11-30 Processes and intermediates for preparing cis(+)3-[4,6-dihydroxy chroman-3-ylmethyl]-4-methoxyaniline
PCT/IB1995/000846 WO1996016955A1 (en) 1994-11-30 1995-10-06 Processes and intermediates for preparing cis(+)3-[4,-6-dihydroxychroman-3-ylmethyl]-4-methoxyaniline

Publications (2)

Publication Number Publication Date
MX9703989A true MX9703989A (es) 1997-09-30
MXPA97003989A MXPA97003989A (es) 1998-07-03

Family

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Also Published As

Publication number Publication date
EP0794951A1 (en) 1997-09-17
US5539128A (en) 1996-07-23
CA2204604C (en) 2002-02-19
WO1996016955A1 (en) 1996-06-06
JP3041049B2 (ja) 2000-05-15
JPH10500143A (ja) 1998-01-06
EP0794951B1 (en) 2000-04-12
GR3033608T3 (en) 2000-10-31
DK0794951T3 (da) 2000-07-10
FI972284A (fi) 1997-05-29
PT794951E (pt) 2000-07-31
DE69516305T2 (de) 2001-02-15
FI972284A0 (fi) 1997-05-29
ES2144628T3 (es) 2000-06-16
ATE191715T1 (de) 2000-04-15
DE69516305D1 (de) 2000-05-18
CA2204604A1 (en) 1996-06-06

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