MX9702664A - Tirosina cinasa receptora humana, her4 de la familia del receptor del factor del crecimiento epidermico. - Google Patents
Tirosina cinasa receptora humana, her4 de la familia del receptor del factor del crecimiento epidermico.Info
- Publication number
- MX9702664A MX9702664A MX9702664A MX9702664A MX9702664A MX 9702664 A MX9702664 A MX 9702664A MX 9702664 A MX9702664 A MX 9702664A MX 9702664 A MX9702664 A MX 9702664A MX 9702664 A MX9702664 A MX 9702664A
- Authority
- MX
- Mexico
- Prior art keywords
- her4
- tyrosine kinase
- receptor tyrosine
- expression
- human receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF] (urogastrone)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
Abstract
Se describen la clonacion molecular, expresion y características biologicas de una tirosina cinasa receptora novedosa relacionada con el receptor del factor de crecimiento epidérmico, llamada HER4/p180erbB4. También se describe un ligando de HER4 capaz de inducir la diferencia celular de las células de cáncer de mama. En vista de la expresion de HER4 en varios cánceres humanos y en ciertos tejidos de origen neuronal y muscular, se proporcionan varios usos de diagnosticos y terapéuticos de las composiciones derivados de HER4 y biologicas relacionadas con HER4.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32344294A | 1994-10-14 | 1994-10-14 | |
PCT/US1995/013524 WO1996012019A2 (en) | 1994-10-14 | 1995-10-10 | Her4 human receptor tyrosine kinase or the epidermal growth factor receptor family |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9702664A true MX9702664A (es) | 1997-06-28 |
Family
ID=23259216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9702664A MX9702664A (es) | 1994-10-14 | 1995-10-10 | Tirosina cinasa receptora humana, her4 de la familia del receptor del factor del crecimiento epidermico. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0787187A1 (es) |
JP (1) | JPH10507362A (es) |
AU (1) | AU3963295A (es) |
CA (1) | CA2202533A1 (es) |
FI (1) | FI971532A (es) |
IL (1) | IL115642A0 (es) |
MX (1) | MX9702664A (es) |
NO (1) | NO971686L (es) |
WO (1) | WO1996012019A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999019488A1 (en) * | 1997-10-15 | 1999-04-22 | Children's Medical Center Corporation | Novel human egf receptors and use thereof |
AU1518799A (en) * | 1997-10-31 | 1999-05-24 | Georgetown University Medical Center | Erbb-4 targeted ribozymes |
JP2006517109A (ja) | 2003-02-07 | 2006-07-20 | プロテイン デザイン ラブス インコーポレイテッド | アンフィレグリン抗体ならびに癌および乾癬を処置するためのその使用 |
US8652787B2 (en) | 2008-11-12 | 2014-02-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of ERBB4 as a prognostic and therapeutic marker for melanoma |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2103323A1 (en) * | 1992-11-24 | 1994-05-25 | Gregory D. Plowman | Her4 human receptor tyrosine kinase |
-
1995
- 1995-10-10 WO PCT/US1995/013524 patent/WO1996012019A2/en not_active Application Discontinuation
- 1995-10-10 JP JP8513469A patent/JPH10507362A/ja active Pending
- 1995-10-10 CA CA002202533A patent/CA2202533A1/en not_active Abandoned
- 1995-10-10 EP EP95937555A patent/EP0787187A1/en not_active Withdrawn
- 1995-10-10 AU AU39632/95A patent/AU3963295A/en not_active Abandoned
- 1995-10-10 MX MX9702664A patent/MX9702664A/es unknown
- 1995-10-15 IL IL11564295A patent/IL115642A0/xx unknown
-
1997
- 1997-04-11 FI FI971532A patent/FI971532A/fi not_active IP Right Cessation
- 1997-04-11 NO NO971686A patent/NO971686L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU3963295A (en) | 1996-05-06 |
JPH10507362A (ja) | 1998-07-21 |
WO1996012019A2 (en) | 1996-04-25 |
EP0787187A1 (en) | 1997-08-06 |
NO971686L (no) | 1997-06-16 |
WO1996012019A3 (en) | 1996-08-15 |
FI971532A (fi) | 1997-06-11 |
NO971686D0 (no) | 1997-04-11 |
CA2202533A1 (en) | 1996-04-25 |
IL115642A0 (en) | 1996-01-19 |
FI971532A0 (fi) | 1997-04-11 |
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