EP0716614A4 - Treatment of human tumors by genetic transformation of human tumor cells - Google Patents
Treatment of human tumors by genetic transformation of human tumor cellsInfo
- Publication number
- EP0716614A4 EP0716614A4 EP94926678A EP94926678A EP0716614A4 EP 0716614 A4 EP0716614 A4 EP 0716614A4 EP 94926678 A EP94926678 A EP 94926678A EP 94926678 A EP94926678 A EP 94926678A EP 0716614 A4 EP0716614 A4 EP 0716614A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- human
- treatment
- tumor cells
- genetic transformation
- tumors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11666993A | 1993-09-03 | 1993-09-03 | |
US116669 | 1993-09-03 | ||
PCT/US1994/009961 WO1995006486A1 (en) | 1993-09-03 | 1994-09-02 | Treatment of human tumors by genetic transformation of human tumor cells |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0716614A1 EP0716614A1 (en) | 1996-06-19 |
EP0716614A4 true EP0716614A4 (en) | 1998-02-04 |
Family
ID=22368537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94926678A Withdrawn EP0716614A4 (en) | 1993-09-03 | 1994-09-02 | Treatment of human tumors by genetic transformation of human tumor cells |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0716614A4 (en) |
JP (1) | JPH09505557A (en) |
CA (1) | CA2169557A1 (en) |
WO (1) | WO1995006486A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6555108B1 (en) | 1990-09-14 | 2003-04-29 | The General Hospital Corporation | Implanting HSV-TK retrovirus producing cells to treat tumors |
US6537541B1 (en) | 1990-09-14 | 2003-03-25 | The General Hospital Corporation | Implantation of HSV-TK retrovirus producer cells to destroy glioma |
CN1151186A (en) * | 1994-05-02 | 1997-06-04 | 华盛顿大学 | Thymidine kinase mutants |
US6451571B1 (en) | 1994-05-02 | 2002-09-17 | University Of Washington | Thymidine kinase mutants |
US7087582B1 (en) | 1995-09-26 | 2006-08-08 | Regents Of The University Of Michigan | Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21 |
US6207648B1 (en) | 1997-07-24 | 2001-03-27 | Trustees Of Boston University | Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy |
GB9801902D0 (en) | 1998-01-29 | 1998-03-25 | Cancer Res Campaign Tech | A gene promoter |
WO2000034497A2 (en) | 1998-12-09 | 2000-06-15 | The General Hospital Corporation | Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors |
US6677155B1 (en) | 1999-04-22 | 2004-01-13 | The General Hospital Corporation | Triple hybrid amplicon vector systems to generate retroviral packaging lines |
US6770632B1 (en) | 1999-07-16 | 2004-08-03 | The General Hospital Corporation | Folypolyglutamyl synthetase gene transfer to enhance antifolate |
WO2002053576A1 (en) | 2001-01-05 | 2002-07-11 | The General Hospital Corporation | Viral delivery system for infectious transfer of large genomic dna inserts |
US10980896B2 (en) | 2013-10-29 | 2021-04-20 | President And Fellows Of Harvard College | Methods and compositions for inhibiting oxidative stress |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4583538A (en) * | 1984-05-04 | 1986-04-22 | Onik Gary M | Method and apparatus for stereotaxic placement of probes in the body utilizing CT scanner localization |
US4813399A (en) * | 1986-07-18 | 1989-03-21 | Gordon Robert T | Process for the treatment of neurological or neuromuscular diseases and development |
US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
-
1994
- 1994-09-02 EP EP94926678A patent/EP0716614A4/en not_active Withdrawn
- 1994-09-02 CA CA002169557A patent/CA2169557A1/en not_active Abandoned
- 1994-09-02 JP JP7508296A patent/JPH09505557A/en active Pending
- 1994-09-02 WO PCT/US1994/009961 patent/WO1995006486A1/en not_active Application Discontinuation
Non-Patent Citations (9)
Title |
---|
BRAIN NERVE (TOKYO), vol. 38, no. 6, 1986, pages 593 - 598 * |
CULVER ET AL: "IN VIVO GENE TRANSFER WITH RETROVIRAL VECTOR-PRODUCER CELLS FOR TREATMENT OF EXPERIMENTAL BRAIN TUMORS", SCIENCE, vol. 256, 1992, pages 1550 - 1552, XP002045618 * |
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; OKAMOTO ET AL: "CLINICAL STUDIES OF ADOPTIVE IMMUNOTHERAPY OF HUMAN DISSEMINATED BRAIN TUMORS WITH LYMPHOKINE-ACTIVATED KILLER CELLS AND RECOMBINANT INTERLEUKIN 2", XP002045621 * |
DATABASE MEDLINE FILE SERVER STN KARLSRUHE; PLUNKETT ET AL: "STEROTAXIC IMPLANTATION OF DISPERSED CELL SUSPENSIONS INTO BRAIN. A SYSTEMATIC APPRAISAL OF CELL PLACEMENT AND SURVIVAL", XP002045622 * |
GILBERT ET AL: "CELL TRANSPLANTATION OF GENETICALLY ALTERED CELLS ON BIODEGRADABLE POLYMER SCAFFOLDS IN SYNGENEIC RATS", TRANSPLANTATION, vol. 56, August 1993 (1993-08-01), pages 423 - 427, XP002045620 * |
JOURNAL OF NEUROSURGERY, vol. 69, no. 2, 1988, pages 228 - 233 * |
RAM ET AL: "IN SITU RETROVIRAL-MEDIATED GENE TRANSFER FOR THE TREATMENT OF BRAIN TUMORS IN RATS", CANCER RESEARCH, vol. 53, 1 January 1993 (1993-01-01), pages 83 - 88, XP002045617 * |
See also references of WO9506486A1 * |
SHORT ET AL: "GENE DELIVERY TO GLIOMA CELLS IN RAT BRAIN BY GRAFTING OF A RETROVIRUS PACKAGING CELL LINE", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 27, 1990, pages 427 - 433, XP002045619 * |
Also Published As
Publication number | Publication date |
---|---|
JPH09505557A (en) | 1997-06-03 |
WO1995006486A1 (en) | 1995-03-09 |
CA2169557A1 (en) | 1995-03-09 |
EP0716614A1 (en) | 1996-06-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19960223 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19971218 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20000403 |