MX9605131A - Formulacion estable de lactona de 7-etil-camptotecina y metodo para usar la misma. - Google Patents
Formulacion estable de lactona de 7-etil-camptotecina y metodo para usar la misma.Info
- Publication number
- MX9605131A MX9605131A MX9605131A MX9605131A MX9605131A MX 9605131 A MX9605131 A MX 9605131A MX 9605131 A MX9605131 A MX 9605131A MX 9605131 A MX9605131 A MX 9605131A MX 9605131 A MX9605131 A MX 9605131A
- Authority
- MX
- Mexico
- Prior art keywords
- camptothecin
- ethyl
- stable formulation
- ecpt
- cpt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Abstract
La camptotecina (CPT) y la 7-etilcamptotecina (ECPT) son poco solubles enagua. Debido a su poca solubilidad en agua, no se administran directamente por vía parenteral u oral a pacientes humanos para inhibir el desarrollo de tumores. La invencion proporciona una formulacion farmacéuticamente aceptable en forma de una solucion o suspension ácida que comprende (1) CPT o ECPT, predominantemente en la forma lactona deseada (1a') (en la que R es hidrogeno o etilo) y (2) dimetilisosorbida o dimetilacetamida.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/234,131 US5604233A (en) | 1994-04-28 | 1994-04-28 | Lactone stable formulation of 7-ethyl camptothecin and methods for uses thereof |
US08/240,035 US5597829A (en) | 1994-05-09 | 1994-05-09 | Lactone stable formulation of camptothecin and methods for uses thereof |
PCT/EP1995/001432 WO1995029677A1 (en) | 1994-04-28 | 1995-04-18 | Lactone stable formulation of camptothecin or 7-ethyl camptothecin |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9605131A true MX9605131A (es) | 1997-10-31 |
Family
ID=26927598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9605131A MX9605131A (es) | 1994-04-28 | 1995-04-18 | Formulacion estable de lactona de 7-etil-camptotecina y metodo para usar la misma. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0758237B1 (es) |
JP (1) | JP4177891B2 (es) |
CA (1) | CA2188297C (es) |
DE (1) | DE69531611T2 (es) |
MX (1) | MX9605131A (es) |
WO (1) | WO1995029677A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4428900A (en) * | 1999-01-28 | 2000-08-18 | Shshikant Prabhudas Kurani | Novel injectable muscle relaxant formulations |
GB9918885D0 (en) | 1999-08-10 | 1999-10-13 | Pharmacia & Upjohn Spa | Pharmaceutical formulations in hydroxypropymethycellulose capsules |
EP1374855A1 (en) * | 2001-03-30 | 2004-01-02 | Takeda Chemical Industries, Ltd. | Medicinal solutions |
PE20030545A1 (es) * | 2001-10-31 | 2003-06-19 | Schering Corp | Formulaciones de jarabe de ribavirina |
US20040258754A1 (en) * | 2003-06-18 | 2004-12-23 | Valery Alakhov | Compositions for oral administration of camptothecin and its analogs |
DE102008059201A1 (de) * | 2008-11-27 | 2010-06-02 | GÖPFERICH, Achim, Prof. Dr. | In situ präzipitierende Arzneistofflösungen |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3219529A (en) * | 1962-10-04 | 1965-11-23 | American Cyanamid Co | Stable tetracycline solutions |
US5124318A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.R.L. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
US4927638A (en) * | 1986-10-08 | 1990-05-22 | Bristol-Myers Company | Etoposide solutions |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
-
1995
- 1995-04-18 JP JP52795995A patent/JP4177891B2/ja not_active Expired - Fee Related
- 1995-04-18 EP EP95917929A patent/EP0758237B1/en not_active Expired - Lifetime
- 1995-04-18 MX MX9605131A patent/MX9605131A/es unknown
- 1995-04-18 WO PCT/EP1995/001432 patent/WO1995029677A1/en active IP Right Grant
- 1995-04-18 DE DE69531611T patent/DE69531611T2/de not_active Expired - Lifetime
- 1995-04-18 CA CA002188297A patent/CA2188297C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0758237A1 (en) | 1997-02-19 |
DE69531611D1 (en) | 2003-10-02 |
CA2188297A1 (en) | 1995-11-09 |
WO1995029677A1 (en) | 1995-11-09 |
JP4177891B2 (ja) | 2008-11-05 |
EP0758237B1 (en) | 2003-08-27 |
DE69531611T2 (de) | 2004-02-26 |
CA2188297C (en) | 2006-12-19 |
JPH09512280A (ja) | 1997-12-09 |
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