MX9604610A - Derivados ester y carbamato de azolonas anti- helicobacter - Google Patents

Derivados ester y carbamato de azolonas anti- helicobacter

Info

Publication number
MX9604610A
MX9604610A MX9604610A MX9604610A MX9604610A MX 9604610 A MX9604610 A MX 9604610A MX 9604610 A MX9604610 A MX 9604610A MX 9604610 A MX9604610 A MX 9604610A MX 9604610 A MX9604610 A MX 9604610A
Authority
MX
Mexico
Prior art keywords
alkyl
azolones
helicobacter
ester
compounds
Prior art date
Application number
MX9604610A
Other languages
English (en)
Other versions
MXPA96004610A (es
Inventor
Jan Heeres
Joseph Hector Mostmans
Robert Jozef Maria Hendrickx
Louis Jozef Elisabeth Va Veken
Raymond Antoine Stokbroekx
Marcel Jozef Maria Van Der Aa
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX9604610A publication Critical patent/MX9604610A/es
Publication of MXPA96004610A publication Critical patent/MXPA96004610A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Detergent Compositions (AREA)

Abstract

La presente invencion se refiere a un compuesto caracterizado porque tiene la formula: una sal ácida de adicion farmacéuticamente aceptable o una forma estereoquímicamente isomérica del mismo, en donde Y es CH o N; R1, R2 y R3 son cada uno independientemente hidrogeno o alquilo de C1-4; R4 y R5 son cada uno independientemente hidrogeno, halogeno, alquilo de C1-4, alquiloxilo de C1-4, hidroxilo, trifluorometilo, trifluorometiloxilo o difluorometiloxilo; R6 es alquilo de C1-6, hidroxialquilo de C1-6, alquiloxilo de C1-4-alquilo de C1-6, fenilo o fenilalquilo de C1-4; Z es CO o CHOH.
MXPA/A/1996/004610A 1994-04-06 1996-10-04 Derivados ester y carbamato de azolonas anti-helicobacter MXPA96004610A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94200938 1994-04-06
EP94200938.2 1994-04-06

Publications (2)

Publication Number Publication Date
MX9604610A true MX9604610A (es) 1997-11-29
MXPA96004610A MXPA96004610A (es) 1998-07-03

Family

ID=

Also Published As

Publication number Publication date
EP0754180B1 (en) 2001-10-31
IL113254A (en) 1999-03-12
CN1145067A (zh) 1997-03-12
EE9600142A (et) 1997-04-15
IL113254A0 (en) 1995-07-31
JPH09511513A (ja) 1997-11-18
NO964216D0 (no) 1996-10-04
NO964216L (no) 1996-10-04
WO1995027704A1 (en) 1995-10-19
EP0754180A1 (en) 1997-01-22
DE69523581T2 (de) 2002-07-11
HU9602725D0 (en) 1996-11-28
CA2185552A1 (en) 1995-10-19
SK127196A3 (en) 1997-05-07
FI963995A0 (fi) 1996-10-04
HUT76287A (en) 1997-07-28
PL316655A1 (en) 1997-02-03
AU685935B2 (en) 1998-01-29
US5710156A (en) 1998-01-20
AU2137195A (en) 1995-10-30
FI963995A (fi) 1996-10-04
ZA952810B (en) 1996-10-07
NZ283346A (en) 1997-05-26
ATE207910T1 (de) 2001-11-15
BR9507289A (pt) 1997-09-23
DE69523581D1 (de) 2001-12-06
CZ287596A3 (en) 1997-01-15

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