MX9602495A - Peptidos novedosos derivados de autoantigeno para usarse en inmunoterapia de enfermedades autoinmunes. - Google Patents

Peptidos novedosos derivados de autoantigeno para usarse en inmunoterapia de enfermedades autoinmunes.

Info

Publication number
MX9602495A
MX9602495A MX9602495A MX9602495A MX9602495A MX 9602495 A MX9602495 A MX 9602495A MX 9602495 A MX9602495 A MX 9602495A MX 9602495 A MX9602495 A MX 9602495A MX 9602495 A MX9602495 A MX 9602495A
Authority
MX
Mexico
Prior art keywords
autoantigen
peptides
seq
autoimmune diseases
peptides derived
Prior art date
Application number
MX9602495A
Other languages
English (en)
Inventor
Anna Maria Helena Boots
Gijsbertus Franciscus Verheij
Den
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of MX9602495A publication Critical patent/MX9602495A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Rehabilitation Therapy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invencion se refiere a péptidos novedosos derivados del autoantígeno gp-39 CH, dichos péptidos comprendiendo, por lo menos, una de las secuencias de aminoácidos FGRSFTLAS (SEX ID No. 1), FTLASSETG (SEX ID No. 2), YDDQESVKS (SEC ID No. 3) Y FSKIASNTQ (SEC ID No. 4). Los péptidos se asemejan a epítopes de células T restringidas de CHM Clase II presentes en el autoantígeno gp-39 CH en cartílago articular. El gp-39 CH y dichos péptidos, se pueden usar en tratamiento específico de antígeno de destruccion de cartílago articular en enfermedades autoinmunes para inducir tolerancia del sistema inmune. El autoantígeno gp-39 CH y dichos péptidos, también son adecuados para inducir artritis en animales no humanos, preferiblemente ratones. La invencion se refiere además a composiciones farmacéuticas comprendiendo dicho autoantígeno y/o dichos péptidos, un método de diagnostico para la deteccion de células T autorreactivas en una muestra de prueba y equipos de prueba para usarse en dicho método.
MX9602495A 1994-10-27 1995-10-25 Peptidos novedosos derivados de autoantigeno para usarse en inmunoterapia de enfermedades autoinmunes. MX9602495A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94203128 1994-10-27
EP95200886 1995-04-07
PCT/EP1995/004201 WO1996013517A1 (en) 1994-10-27 1995-10-25 Novel peptides derived from autoantigen for use in immunotherapy of autoimmune diseases

Publications (1)

Publication Number Publication Date
MX9602495A true MX9602495A (es) 1997-05-31

Family

ID=26136688

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9602495A MX9602495A (es) 1994-10-27 1995-10-25 Peptidos novedosos derivados de autoantigeno para usarse en inmunoterapia de enfermedades autoinmunes.

Country Status (24)

Country Link
US (1) US5736507A (es)
EP (1) EP0733065B1 (es)
JP (1) JP3755894B2 (es)
KR (1) KR100485979B1 (es)
CN (1) CN1161379C (es)
AT (1) ATE177756T1 (es)
AU (1) AU696827B2 (es)
BR (1) BR9506377A (es)
CA (1) CA2173874A1 (es)
DE (1) DE69508380T2 (es)
DK (1) DK0733065T3 (es)
ES (1) ES2130672T3 (es)
FI (1) FI118472B (es)
GR (1) GR3030296T3 (es)
HK (1) HK1002012A1 (es)
HU (1) HU218027B (es)
IL (1) IL115744A (es)
MX (1) MX9602495A (es)
NO (1) NO316703B1 (es)
NZ (1) NZ295659A (es)
PL (1) PL183761B1 (es)
RU (1) RU2178797C2 (es)
TR (1) TR199501326A2 (es)
WO (1) WO1996013517A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843449A (en) * 1996-03-25 1998-12-01 Akzo Nobel N.V. Proteins and novel peptides derived from autoantigen for use in immunotherapy of autoimmune diseases
TW575583B (en) * 1996-04-24 2004-02-11 Akzo Nobel Nv Novel peptides suitable for use in antigen specific immunosuppressive therapy
US6881824B1 (en) 1996-04-24 2005-04-19 Akzo Nobel N.V. Peptides suitable for use in antigen specific immunosuppressive therapy
EP0947524A1 (en) * 1998-03-30 1999-10-06 Upither B.V. Novel peptides for the treatment of autoimmune diseases
JP2002521388A (ja) 1998-07-23 2002-07-16 アクゾ・ノベル・エヌ・ベー 自己免疫疾患の免疫療法に使用するための新規ペプチド
EP1100526A2 (en) * 1998-07-23 2001-05-23 Akzo Nobel N.V. USE OF HC gp-39 IN IMMUNE DISEASES
TR200201036T2 (tr) * 1999-10-18 2002-08-21 Akzo Nobel N.V. İmmünoterapide kullanmak için değiştirilmiş peptitler ve peptido-taklitleri
US7265208B2 (en) * 2001-05-01 2007-09-04 The Regents Of The University Of California Fusion molecules and treatment of IgE-mediated allergic diseases
BR0211468A (pt) * 2001-07-24 2004-11-23 Univ Yale Métodos de tratar e de prevenir uma doença inflamátoria em um mamìfero e de identificar um composto útil para tratar uma doença inflamatória em um mamìfero, composto, e kits para tratar e para prevenir uma doença inflamatória em um mamìfero
WO2005081980A2 (en) * 2004-02-25 2005-09-09 Medimmune, Inc. Methods and compositions relating to chitinases and chitinase-like molecules and modulation of osteoclasts
WO2007027748A2 (en) * 2005-08-31 2007-03-08 Medimmune, Inc. C/clp antagonists and methods of use thereof
RU2302872C9 (ru) * 2006-06-22 2008-12-20 Общество С Ограниченной Ответственностью "Сиа Пептайдс" Средство, нормализующее функции хрящевой ткани, и способ его получения
GB0710529D0 (en) 2007-06-01 2007-07-11 Circassia Ltd Vaccine
SI2190473T1 (sl) 2007-08-15 2013-05-31 Circassia Limited Peptid z zmanjšano tvorbo dimerov
JP5705113B2 (ja) * 2008-08-15 2015-04-22 サーカッシア リミテッド Ｉｌ−１０産生の刺激のためのアレルゲン由来のｔ細胞抗原
SI2153841T2 (sl) 2008-08-15 2016-02-29 Circassia Limited Cepivo, ki obsega peptide Amb a 1, za uporabo pri zdravljenju alergije na ambrozijo
CN103784952B (zh) 2009-02-05 2016-08-17 切尔卡西亚有限公司 用于疫苗的草肽
EP2493487B1 (en) * 2009-10-27 2016-08-24 Erytech Pharma Composition to induce specific immune tolerance
WO2017041051A1 (en) 2015-09-04 2017-03-09 Sqz Biotechnologies Company Intracellular delivery of biomolecules to cells comprising a cell wall

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6323898A (ja) * 1986-07-16 1988-02-01 Dainippon Pharmaceut Co Ltd 新規ポリペプチド及びそれをコ−ドするｄｎａ並びにそれらの製法
IL92629A0 (en) * 1989-12-10 1990-08-31 Yeda Res & Dev Direct binding of t-cell epitopes to mhc gene products on intact living antigen presenting cells and the use thereof for identifying epitopes causing autoimmune diseases and pharmaceutical compositions for treating such diseases
CA2164498C (en) * 1993-07-09 2007-09-11 Paul A. Price Assay for ykl-40 as a marker for degradation of mammalian connective tissue matrices

Also Published As

Publication number Publication date
JPH09507861A (ja) 1997-08-12
ES2130672T3 (es) 1999-07-01
US5736507A (en) 1998-04-07
AU696827B2 (en) 1998-09-17
HUT74847A (en) 1997-02-28
IL115744A0 (en) 1996-01-19
PL315198A1 (en) 1996-10-14
PL183761B1 (pl) 2002-07-31
FI118472B (fi) 2007-11-30
GR3030296T3 (en) 1999-09-30
RU2178797C2 (ru) 2002-01-27
DE69508380T2 (de) 1999-09-09
CA2173874A1 (en) 1996-05-09
TR199501326A2 (tr) 1996-06-21
KR960705848A (ko) 1996-11-08
JP3755894B2 (ja) 2006-03-15
ATE177756T1 (de) 1999-04-15
NO962695L (no) 1996-06-26
CN1168677A (zh) 1997-12-24
EP0733065B1 (en) 1999-03-17
HU218027B (hu) 2000-05-28
FI962619A0 (fi) 1996-06-25
HK1002012A1 (en) 1998-07-24
BR9506377A (pt) 1997-09-16
DE69508380D1 (de) 1999-04-22
NO962695D0 (no) 1996-06-26
NO316703B1 (no) 2004-04-13
IL115744A (en) 2000-07-16
DK0733065T3 (da) 1999-10-11
CN1161379C (zh) 2004-08-11
NZ295659A (en) 1998-02-26
KR100485979B1 (ko) 2006-01-27
AU3925295A (en) 1996-05-23
WO1996013517A1 (en) 1996-05-09
FI962619A (fi) 1996-06-25
HU9601401D0 (en) 1996-07-29
EP0733065A1 (en) 1996-09-25

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Legal Events

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FG Grant or registration
PD Change of proprietorship

Owner name: N.V. ORGANON.*

MM Annulment or lapse due to non-payment of fees