MX9403633A - Un procedimiento para incorporar un ligando dentro de un peptido y elprecursor de ligando para incorporacion a un peptido. - Google Patents

Un procedimiento para incorporar un ligando dentro de un peptido y elprecursor de ligando para incorporacion a un peptido.

Info

Publication number
MX9403633A
MX9403633A MX9403633A MX9403633A MX9403633A MX 9403633 A MX9403633 A MX 9403633A MX 9403633 A MX9403633 A MX 9403633A MX 9403633 A MX9403633 A MX 9403633A MX 9403633 A MX9403633 A MX 9403633A
Authority
MX
Mexico
Prior art keywords
peptide
league
incorporating
synthesis
incorporation
Prior art date
Application number
MX9403633A
Other languages
English (en)
Inventor
T Jeffrey Dunn
Ananthachari Srinivasan
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Publication of MX9403633A publication Critical patent/MX9403633A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen composiciones y métodos de incorporación de precursores deligando y ligandos en cualquier ubicación dentro de un péptido durante lasíntesis de péptido. Los derivados de ácido 2,4,5-triaminopentanóico yácido t-aminoglutámico son incorporados selectivamente al péptido durantela síntesis de fase sólida o de fase líquida, dependiendo de la elecciónde grupos protectores. La síntesis de ligando puede completarse después enun momento posterior para producir N3S, N2S2, y agentes quelatadores deltipo EDTA.
MX9403633A 1993-05-14 1994-05-16 Un procedimiento para incorporar un ligando dentro de un peptido y elprecursor de ligando para incorporacion a un peptido. MX9403633A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6209993A 1993-05-14 1993-05-14

Publications (1)

Publication Number Publication Date
MX9403633A true MX9403633A (es) 1995-01-31

Family

ID=22040220

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9403633A MX9403633A (es) 1993-05-14 1994-05-16 Un procedimiento para incorporar un ligando dentro de un peptido y elprecursor de ligando para incorporacion a un peptido.

Country Status (7)

Country Link
US (2) US5734011A (es)
EP (1) EP0697884B1 (es)
JP (1) JPH08510258A (es)
AU (1) AU6834194A (es)
DE (1) DE69421698T2 (es)
MX (1) MX9403633A (es)
WO (1) WO1994026294A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002192A1 (en) 1996-07-12 1998-01-22 Immunomedics, Inc. Radiometal-binding peptide analogues
US7767826B2 (en) * 2007-10-05 2010-08-03 Pharmatech International, Inc. Process for the synthesis of L-(+)-ergothioneine

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322341A (en) * 1980-05-13 1982-03-30 Fujisawa Pharmaceutical Co Peptide, process for preparation thereof and use thereof
US4725582A (en) * 1978-11-14 1988-02-16 Fujisawa Pharmaceutical Company, Ltd. Peptide, process for preparation thereof and use thereof
FR2460290A1 (fr) * 1979-06-29 1981-01-23 Rhone Poulenc Ind Nouveaux tetra- ou pentapeptides, leur preparation et les medicaments qui les contiennent
GR79114B (es) * 1981-01-29 1984-10-02 Fujisawa Pharmaceutical Co
US4479930A (en) * 1982-07-26 1984-10-30 Trustees Of The University Of Massachusetts Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
US4668503A (en) * 1982-07-26 1987-05-26 Trustees Of University Of Massachusetts Process for labeling amines with 99m Tc
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
FR2619108B1 (fr) * 1987-08-07 1989-12-01 Rhone Poulenc Sante Procede de preparation de l'acide n6-benzyloxycarbonyl diamino-2,6 pimelamique sous les formes l,l ou d,d ou racemique
US5075099A (en) * 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5094950A (en) * 1988-06-07 1992-03-10 Nihon Medi-Physics Co., Ltd. Diethylenetriamine pentaacetic acid derivatives
ZW11290A1 (en) * 1989-07-14 1990-10-31 Smithkline Beecham Corp Hemoregulatory peptides

Also Published As

Publication number Publication date
DE69421698T2 (de) 2000-03-09
US5798444A (en) 1998-08-25
EP0697884B1 (en) 1999-11-17
AU6834194A (en) 1994-12-12
DE69421698D1 (de) 1999-12-23
EP0697884A1 (en) 1996-02-28
JPH08510258A (ja) 1996-10-29
US5734011A (en) 1998-03-31
EP0697884A4 (en) 1997-02-26
WO1994026294A1 (en) 1994-11-24

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