MX9307044A - Polipetidos de afinidad modificada de anticuerpos que se unen a quelatos metalicos. - Google Patents
Polipetidos de afinidad modificada de anticuerpos que se unen a quelatos metalicos.Info
- Publication number
- MX9307044A MX9307044A MX9307044A MX9307044A MX9307044A MX 9307044 A MX9307044 A MX 9307044A MX 9307044 A MX9307044 A MX 9307044A MX 9307044 A MX9307044 A MX 9307044A MX 9307044 A MX9307044 A MX 9307044A
- Authority
- MX
- Mexico
- Prior art keywords
- polypethydes
- antibodies
- modified affinity
- affinity
- bind metallic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Está invención aporta un polipéptido que tiene una secuencia de aminoácidos que incluye una secuencia de una región determinante de complementariedad (CDR) de un anticuerpo nativo que tiene una sustitución aminoacidica, teniendo el polipétido afinidad por la unión de un quelato metálico de EDTA a un análogo de EDTA que es aproximadamente igual o modificada de la afinidad de unión del anticuerpo nativo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97523092A | 1992-11-12 | 1992-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9307044A true MX9307044A (es) | 1994-05-31 |
Family
ID=25522807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9307044A MX9307044A (es) | 1992-11-12 | 1993-11-11 | Polipetidos de afinidad modificada de anticuerpos que se unen a quelatos metalicos. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0623675A1 (es) |
JP (1) | JPH06343489A (es) |
AU (1) | AU5060293A (es) |
CA (1) | CA2102848A1 (es) |
HU (1) | HUT67186A (es) |
MX (1) | MX9307044A (es) |
ZA (1) | ZA938243B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0759291A1 (en) | 1995-08-14 | 1997-02-26 | The Procter & Gamble Company | Cleansing preparation and articles comprising a cleansing preparation |
AUPO066096A0 (en) * | 1996-06-26 | 1996-07-18 | Peptide Delivery Systems Pty Ltd | Oral delivery of peptides |
US6071490A (en) * | 1998-05-07 | 2000-06-06 | Immunomedics, Inc. | Position emission tomography using gallium-68 chelates |
ES2216510T3 (es) * | 1998-05-07 | 2004-10-16 | Immunomedics, Inc. | Tomografia de emision de positrones utilizando quelatos de galio 68. |
US7405320B2 (en) | 1998-06-22 | 2008-07-29 | Immunomedics, Inc. | Therapeutic and diagnostic conjugates for use with multispecific antibodies |
US7833528B2 (en) | 1998-06-22 | 2010-11-16 | Immunomedics, Inc. | Use of multispecific, non-covalent complexes for targeted delivery of therapeutics |
US7138103B2 (en) | 1998-06-22 | 2006-11-21 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
US6962702B2 (en) | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
US7387772B1 (en) | 1999-06-22 | 2008-06-17 | Immunimedics, Inc. | Chimeric, human and humanized anti-CSAP monoclonal antibodies |
US7052872B1 (en) | 1999-06-22 | 2006-05-30 | Immunomedics, Inc. | Bi-specific antibodies for pre-targeting diagnosis and therapy |
JP4113670B2 (ja) * | 1998-06-22 | 2008-07-09 | イムノメディクス, インコーポレイテッド | プレターゲッティング診断およびプレターゲッティング治療のための二重特異性抗体の使用 |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
PL1954718T3 (pl) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Przeciwciała skierowane przeciwko A globulomerowi, ich reszty wiążące antygeny, odpowiednie hybrydomy, kwasy nukleinowe, wektory, komórki gospodarze, sposoby wytwarzania tych przeciwciał, kompozycje zawierające te przeciwciała, zastosowania tych przeciwciał i sposoby stosowania tych przeciwciał |
DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
CA2632822C (en) | 2005-12-12 | 2018-08-28 | Ruth Greferath | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
AR062065A1 (es) | 2006-07-14 | 2008-10-15 | Ac Immune Sa | Anticuerpo humanizado |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
BRPI0812484A2 (pt) * | 2007-06-12 | 2018-06-05 | Ac Immune Sa | anticorpo monoclonal, regiões variáveis de cadeia leve e de cadeia pesada, cdr isolada, polinucleotídeo, composição terapêutica, métodos para tratar doenças e distúrbios, para produzir um anticorpo, para tratar ou aliviar os efeitos de doenças e distúrbios, para reduzir a carga de placas no cérebro de um indivíduo, para reduzir a quantidade de placas no cérebro de um indivíduo, para diminuir a quantidade total de abeta solúvel no cérebro de um indivíduo, para reter ou aumentar a capacidade de memória cognitiva em um indivíduo, de diagnose de ou para diagnosticar uma predisposição para uma doença associada com amilóide ou condição em um paciente, para determinar a extensão de carga de placa amiloidogênica em um tecido de um indivíduo, para monitorar doença residual mínima em um indivíduo e para prever responsividade de um indivíduo, linhagem de células, kit de teste, epítopo abeta |
US9403902B2 (en) | 2007-10-05 | 2016-08-02 | Ac Immune S.A. | Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody |
JP2013523182A (ja) | 2010-04-15 | 2013-06-17 | アボット・ラボラトリーズ | アミロイドベータ結合タンパク質 |
CA2806909C (en) | 2010-07-30 | 2019-12-17 | Ac Immune S.A. | Safe and functional humanized antibodies |
EP2603524A1 (en) | 2010-08-14 | 2013-06-19 | AbbVie Inc. | Amyloid-beta binding proteins |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4722892A (en) * | 1984-08-31 | 1988-02-02 | Meares Claude F | Monoclonal antibodies against metal chelates |
ATE107276T1 (de) * | 1988-02-03 | 1994-07-15 | Hybritech Inc | Modifizierte haptene, nützlich als bildformendes agens und als arzneimittel. |
IL89491A0 (en) * | 1988-11-17 | 1989-09-10 | Hybritech Inc | Bifunctional chimeric antibodies |
IL99552A0 (en) * | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
-
1993
- 1993-11-04 ZA ZA938243A patent/ZA938243B/xx unknown
- 1993-11-10 CA CA002102848A patent/CA2102848A1/en not_active Abandoned
- 1993-11-10 HU HU9303200A patent/HUT67186A/hu unknown
- 1993-11-10 EP EP93308960A patent/EP0623675A1/en not_active Withdrawn
- 1993-11-10 AU AU50602/93A patent/AU5060293A/en not_active Abandoned
- 1993-11-11 JP JP5282435A patent/JPH06343489A/ja active Pending
- 1993-11-11 MX MX9307044A patent/MX9307044A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU5060293A (en) | 1994-05-26 |
CA2102848A1 (en) | 1994-05-13 |
HU9303200D0 (en) | 1994-01-28 |
ZA938243B (en) | 1995-05-04 |
EP0623675A1 (en) | 1994-11-09 |
HUT67186A (en) | 1995-02-28 |
JPH06343489A (ja) | 1994-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX9307044A (es) | Polipetidos de afinidad modificada de anticuerpos que se unen a quelatos metalicos. | |
DE3584443D1 (de) | Monoklonale antikoerper gegen metallchelate. | |
PE20090046A1 (es) | Anticuerpo recombinante humanizado anti-interleuquina 10 | |
DK0937140T3 (da) | Antistofmolekyler, som interagerer specifikt med et målmolekyles aktive sted eller klöft | |
UA89017C2 (uk) | ЛЮДСЬКЕ АНТИТІЛО, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ЛЮДСЬКИМ TNFSF13b | |
ATE172743T1 (de) | Nachweis von kollagenabbau -i(in vivo) | |
CY1118709T1 (el) | Αντιγονικα πεπτιδια του παραγοντα διεγερσης αποικιων των κοκκινοκυτταρων (gm-csf) και αντισωματα για ton gm-csf | |
CY1110877T1 (el) | Αλλαγη των συγγενειων συνδεσης me fcrn ή των ημιζωων ορου αντισωματων με μεταλλαξιγενεση | |
DE69527975D1 (de) | Humanisierte antikörper gegen cd38 | |
ATE473754T1 (de) | Verfahren zur manipulation der zelldifferenzierung | |
GEP20094829B (en) | Fully human antibodies against human 4-1bb (cd137) | |
PT804237E (pt) | Anticorpos humanizados contra a molecula de adesao leucocitaria vla-4 | |
DK0724456T3 (da) | CD40-Antistoffer | |
ATE421976T1 (de) | Fab fragmentbibliotheken und verfahren für deren verwendung | |
ES2173130T3 (es) | Metodo de fijacion de material al peptido beta-amiloide. | |
RU2017146220A (ru) | Конъюгированные через cys80 иммуноглобулины | |
ATE182366T1 (de) | Immunoassays für und monoklonale antikörper gegen prothrombin-aktivierende peptide und ihre abbauprodukte | |
ATE180489T1 (de) | Für leberzellkarzinom spezifisches onkogen | |
NZ535908A (en) | HIV regulatory and auxilliary peptides, antigens, vaccine compositions, immunoassay kit and a method of detecting antibodies induced by HIV | |
EP0725081A4 (en) | MONOCLONAL ANTIBODIES AGAINST MxA OF Mx PROTEIN OF MAN | |
ES2114547T3 (es) | Anticuerpos monoclonales contra el virus de la hepatitis c. | |
CA2137280A1 (fr) | Clonage du gene codant pour la proteine gp28.5 de toxoplasma gondii; fragments peptidiques de cette proteine et leurs applications | |
ATE543906T1 (de) | Antigen von streptococcus aus der b-gruppe | |
DE69428041D1 (de) | Inhibierung von Leukozytenadhäsion | |
ATE122895T1 (de) | Monoklonale antikörper gegen den interleukin 2- rezeptor. |