ATE182366T1 - Immunoassays für und monoklonale antikörper gegen prothrombin-aktivierende peptide und ihre abbauprodukte - Google Patents

Immunoassays für und monoklonale antikörper gegen prothrombin-aktivierende peptide und ihre abbauprodukte

Info

Publication number
ATE182366T1
ATE182366T1 AT91901032T AT91901032T ATE182366T1 AT E182366 T1 ATE182366 T1 AT E182366T1 AT 91901032 T AT91901032 T AT 91901032T AT 91901032 T AT91901032 T AT 91901032T AT E182366 T1 ATE182366 T1 AT E182366T1
Authority
AT
Austria
Prior art keywords
immunoassays
monoclonal antibodies
peptides
activate
antibodies against
Prior art date
Application number
AT91901032T
Other languages
English (en)
Inventor
Marcie J Hursting
Bryan T Butman
Jerald P Steiner
Bryant M Moore
Frederick A Dombrose
Original Assignee
Akzo Nobel Nv
Marcie J Hursting
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23714193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE182366(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Akzo Nobel Nv, Marcie J Hursting filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of ATE182366T1 publication Critical patent/ATE182366T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6429Thrombin (3.4.21.5)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21005Thrombin (3.4.21.5)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Exhaust Gas After Treatment (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
AT91901032T 1989-11-06 1990-11-02 Immunoassays für und monoklonale antikörper gegen prothrombin-aktivierende peptide und ihre abbauprodukte ATE182366T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43196489A 1989-11-06 1989-11-06

Publications (1)

Publication Number Publication Date
ATE182366T1 true ATE182366T1 (de) 1999-08-15

Family

ID=23714193

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91901032T ATE182366T1 (de) 1989-11-06 1990-11-02 Immunoassays für und monoklonale antikörper gegen prothrombin-aktivierende peptide und ihre abbauprodukte

Country Status (15)

Country Link
US (1) US5830681A (de)
EP (1) EP0594576B1 (de)
JP (1) JP2918688B2 (de)
KR (1) KR100202773B1 (de)
AT (1) ATE182366T1 (de)
AU (1) AU655918B2 (de)
CA (1) CA2071211C (de)
DE (1) DE69033220T2 (de)
DK (1) DK0594576T3 (de)
ES (1) ES2136598T3 (de)
FI (1) FI109204B (de)
GR (1) GR3031607T3 (de)
IE (1) IE903930A1 (de)
WO (1) WO1991006861A1 (de)
ZA (1) ZA908778B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3727610A1 (de) 1987-08-19 1989-03-02 Behringwerke Ag Synthetische peptide, gegen diese gerichtete antikoerper und deren verwendung
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
CA2258489C (en) 1996-06-28 2004-01-27 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
AUPP460398A0 (en) * 1998-07-10 1998-08-06 Life Therapeutics Limited Lupus anticoagulant
NZ521534A (en) * 2000-02-23 2004-10-29 Besst Test Aps Method for correlating blood coagulation activity with markers in urine
US20020098516A1 (en) * 2000-10-03 2002-07-25 Boystown National Research Hospital Immunodiagnostic determination of usher syndrome type IIA
DE10354403A1 (de) 2003-11-20 2005-06-23 Dade Behring Marburg Gmbh Gegen das Prothrombin-Fragment F 1+2 gerichtete Antikörper, ihre Herstellung und Verwendung
DE102004042124B4 (de) * 2004-08-30 2006-07-06 Dade Behring Marburg Gmbh Homogenes Verfahren zur Bestimmung eines Analyten in Gegenwart eines Überschusses von kreuzreagierenden Substanzen
KR100967614B1 (ko) * 2008-03-14 2010-07-05 주식회사 바이오인프라 Des-R 프로트롬빈 활성 펩티드 단편 F2의 혈청 내농도 측정을 통한 암의 진단 및 스크리닝 방법
DE102008049601A1 (de) * 2008-09-30 2010-04-01 Siemens Healthcare Diagnostics Products Gmbh Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay
DE112010002222B4 (de) 2009-06-04 2024-01-25 Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) Mehr-Proben-Mikrofluidchip fur DNA-Analyse
WO2012051529A1 (en) 2010-10-15 2012-04-19 Lockheed Martin Corporation Micro fluidic optic design
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
EP4239338A1 (de) 2022-03-03 2023-09-06 Siemens Healthcare Diagnostics Products GmbH Globaltest zur feststellung des status des blutgerinnungssystems
WO2023208941A1 (en) 2022-04-26 2023-11-02 Essilor International Photochromic optical article having a mirror coating
EP4325224A1 (de) 2022-08-18 2024-02-21 Siemens Healthcare Diagnostics Products GmbH Thrombozytenaktivierungstest zur diagnose einer heparin-induzierten thrombozytopenie

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3727610A1 (de) * 1987-08-19 1989-03-02 Behringwerke Ag Synthetische peptide, gegen diese gerichtete antikoerper und deren verwendung

Also Published As

Publication number Publication date
GR3031607T3 (en) 2000-01-31
ES2136598T3 (es) 1999-12-01
DE69033220D1 (de) 1999-08-26
FI922017A0 (fi) 1992-05-05
DK0594576T3 (da) 2000-02-07
AU6956391A (en) 1991-05-31
AU655918B2 (en) 1995-01-19
EP0594576A1 (de) 1994-05-04
US5830681A (en) 1998-11-03
IE903930A1 (en) 1991-05-08
ZA908778B (en) 1991-10-30
CA2071211A1 (en) 1991-05-07
EP0594576B1 (de) 1999-07-21
EP0594576A4 (de) 1993-03-15
JP2918688B2 (ja) 1999-07-12
WO1991006861A1 (en) 1991-05-16
JPH05504473A (ja) 1993-07-15
FI922017A (fi) 1992-05-05
CA2071211C (en) 2003-02-18
KR100202773B1 (ko) 1999-06-15
FI109204B (fi) 2002-06-14
DE69033220T2 (de) 2000-01-20

Similar Documents

Publication Publication Date Title
ATE182366T1 (de) Immunoassays für und monoklonale antikörper gegen prothrombin-aktivierende peptide und ihre abbauprodukte
ATE182625T1 (de) Rekombinante anti-vla4 antikörpermoleküle
NO331148B1 (no) Anvendelse av et monoklonalt eller polyklonalt antistoff, samt fremgangsmate og kit for in vitro diagnose.
DE69228701D1 (de) Fragmente von Prion Proteinen.
ES2171705T3 (es) Complejos de polipeptido-dendrimero.
ATE480562T1 (de) Veränderung von fcrn-bindungsaffinitäten oder von serumhalbwertszeiten von antikörpern mittels mutagenese
ATE172743T1 (de) Nachweis von kollagenabbau -i(in vivo)
DE69531679D1 (de) Für e-selectin und p-selectin spezifische kreuzreaktive monoklonale antikörper
DK0930365T3 (da) Bindingsdomæner i Serrate-protein
DE69128273D1 (de) Für toxin b von clostridium difficile spezifische monoklonale antikörper
NO982715L (no) Endotel celle-proliferasjonsinhibitor og fremgangsmate for anvendelse
DE69132122D1 (de) Reinigung von cytokeratinfragmenten
ES2072423T3 (es) Anticuerpo monoclonal e inmunoensayo para el factor beta xiia de coagulacion de la sangre.
ATE274190T1 (de) Methoden und kits zum sequenzieren von polypeptiden
ATE282830T1 (de) Immuntest für human chromogranine a (cga), antikörper, reagenz und dazu geeigneter testsatz
ATE230761T1 (de) Monoklonale antikörper gegen einen komplex aus humanem act und einer serinprotease
DE69434087D1 (de) ENTEROTOXINE VON SHIGELLA FLEXNERI 2a
SE9602234D0 (sv) A novel diagnostic method utilizing ECP, and reagents to be used in the methods
ATE154395T1 (de) Monoklonale antikörper
EP0343946A3 (de) CEA-Fragmente
NO982227D0 (no) Urogenitalcarcinom-TPL komplekspeptider og antistoffer derav
Sheng et al. Electroimmunoblotting of myelin basic protein peptides: a novel approach to the rapid characterisation of antigenic specificities of monoclonal and polyclonal anti-MBP antibodies
SE8705137D0 (sv) Diagnostic method for primary biliary cirrhosis and antibodies suitable to be used in certain versions of the method
TW288020B (en) Monoclonal antibodies specific to methamphetamine, hybridoma producing the antibodies, kits containing the antibodies and uses thereof
DE69333683D1 (de) Antikörper-testbesteck zur bestimmung von amylin

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
RZN Patent revoked