MX9305910A - 1-heteroaril-azetidinas y - pirrolidinas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. - Google Patents
1-heteroaril-azetidinas y - pirrolidinas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.Info
- Publication number
- MX9305910A MX9305910A MX9305910A MX9305910A MX9305910A MX 9305910 A MX9305910 A MX 9305910A MX 9305910 A MX9305910 A MX 9305910A MX 9305910 A MX9305910 A MX 9305910A MX 9305910 A MX9305910 A MX 9305910A
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- group
- hydrogen atom
- piperazino
- mono
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- -1 hydroxy, hydroxymethyl Chemical group 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000198 serotonin 5-HT3 receptor agonist Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a las nuevas 1-heteroaril-azetidinas y -pirrolidinas, dotadas de actividad 5-HT3 agonista, de fórmula (I), (Ver Fórmula); en la cual A representa un grupo -CHCH, -CHN- ó -NCH-; R representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo de 1 a 4 átomos de carbono, alcoxi de 1 a 4 átomos de carbono, alquiltio de 1 a 4 átomos de carbono, un grupo ciano, carboxamido, trifluorometilo, vinilo, formilo, un grupo carboxi libre, salificado o esterificado, un grupo hidroxi, hidroximetilo, mercapto, un grupo amino, mono- o di-alquilamino de 1 a 4 átomos de carbono, aminometilo, mono- o di-alquilaminometilo de 1 a 4 átomos de carbono, 1-piperidino, 1-pirrolidino, 1-piperazino ó 4-alquil(de 1 a 4 átomos de carbono)-1-piperazino, este grupo R puede substituir cualquiera de los átomos de hidrógeno del núcleo heteroarílico; R1 es un átomo de hidrógeno o un grupo metilo; R2 y R3, idénticos o diferentes, representan un átomo de hidrógeno o un grupo alquilo de 1 a 4 átomos de carbono; n es 1 ó 2, m es 1 ó 0, y m + n es mayor o igual de 2; así como sus sales de adición con los ácidos minerales u orgánicos. La invención se refiere también al procedimiento de preparación de los nuevos compuestos, los intermediarios del procedimiento y la utilización de los compuestos (I) a manera de medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92402643 | 1992-09-25 | ||
| EP92402642 | 1992-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9305910A true MX9305910A (es) | 1994-05-31 |
Family
ID=26132424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9305910A MX9305910A (es) | 1992-09-25 | 1993-09-24 | 1-heteroaril-azetidinas y - pirrolidinas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US5410057A (es) |
| JP (1) | JPH06192251A (es) |
| AU (1) | AU661198B2 (es) |
| CA (1) | CA2106840A1 (es) |
| HU (1) | HUT65405A (es) |
| MX (1) | MX9305910A (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2106840A1 (en) * | 1992-09-25 | 1994-03-26 | Marco Baroni | Heteroarylazetidines and -pyrrolidines, process for their preparation and pharmaceutical compositions containing them |
| TW432061B (en) * | 1994-08-09 | 2001-05-01 | Pfizer Res & Dev | Lactams |
| US5885983A (en) * | 1996-05-10 | 1999-03-23 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| HUP0200849A2 (hu) * | 2002-03-06 | 2004-08-30 | Sanofi-Synthelabo | N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
| JP2005272338A (ja) * | 2004-03-24 | 2005-10-06 | Nippon Nohyaku Co Ltd | ピリジン誘導体の製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS274601B2 (en) * | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
| US5304555A (en) * | 1987-08-26 | 1994-04-19 | Mitsui Petrochemical Industries, Ltd. | Pyrimidines and pharmaceutically acceptable salts thereof useful in treatment of neurological disorders |
| US5015741A (en) * | 1989-10-03 | 1991-05-14 | Philip Morris Incorporated | Nicotine analogs |
| US5138062A (en) * | 1989-10-03 | 1992-08-11 | Philip Morris Incorporated | Nicotine analogs |
| DE69228017D1 (de) * | 1991-03-27 | 1999-02-11 | Sanofi Sa | Verwendung von 4-Amino-1-(2-Pyridyl)Piperidinen als 5-HT3-Agonisten zur Behandlung und Verhütung von serotoninergen Dysfunktionen |
| ES2107548T3 (es) * | 1991-07-23 | 1997-12-01 | Schering Corp | Compuestos de beta-lactama sustituidos utiles como agentes hipocolesterolemicos y procedimientos para su preparacion. |
| CA2106840A1 (en) * | 1992-09-25 | 1994-03-26 | Marco Baroni | Heteroarylazetidines and -pyrrolidines, process for their preparation and pharmaceutical compositions containing them |
-
1993
- 1993-09-23 CA CA002106840A patent/CA2106840A1/en not_active Abandoned
- 1993-09-24 HU HU9302707A patent/HUT65405A/hu unknown
- 1993-09-24 AU AU47566/93A patent/AU661198B2/en not_active Ceased
- 1993-09-24 MX MX9305910A patent/MX9305910A/es unknown
- 1993-09-24 US US08/127,038 patent/US5410057A/en not_active Expired - Fee Related
- 1993-09-27 JP JP5240188A patent/JPH06192251A/ja not_active Withdrawn
-
1995
- 1995-01-05 US US08/368,915 patent/US5565474A/en not_active Expired - Fee Related
- 1995-06-06 US US08/466,912 patent/US5576320A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUT65405A (en) | 1994-06-28 |
| US5576320A (en) | 1996-11-19 |
| HU9302707D0 (en) | 1993-12-28 |
| AU661198B2 (en) | 1995-07-13 |
| CA2106840A1 (en) | 1994-03-26 |
| AU4756693A (en) | 1994-03-31 |
| JPH06192251A (ja) | 1994-07-12 |
| US5565474A (en) | 1996-10-15 |
| US5410057A (en) | 1995-04-25 |
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