MX9305690A - Aplicacion de cinetica de peptido/receptor celular, utilizando congeneres de somatostatina radiomarcados en la detencion y la diferenciacion in situ ein vivo de tejido neoplastico. - Google Patents

Aplicacion de cinetica de peptido/receptor celular, utilizando congeneres de somatostatina radiomarcados en la detencion y la diferenciacion in situ ein vivo de tejido neoplastico.

Info

Publication number
MX9305690A
MX9305690A MX9305690A MX9305690A MX9305690A MX 9305690 A MX9305690 A MX 9305690A MX 9305690 A MX9305690 A MX 9305690A MX 9305690 A MX9305690 A MX 9305690A MX 9305690 A MX9305690 A MX 9305690A
Authority
MX
Mexico
Prior art keywords
neoplastic tissue
patient
differentiation
congeneres
radiomarked
Prior art date
Application number
MX9305690A
Other languages
English (en)
Inventor
Eugene A Woltering
Thomas M O' Dorisio
M Sue O' Dorisio
Edward W Martin Jr
Original Assignee
Univ Ohio State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ohio State Res Found filed Critical Univ Ohio State Res Found
Publication of MX9305690A publication Critical patent/MX9305690A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/392—Radioactive markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1.-Un método para la detención y diferenciación de tejido neoplástico en un paciente que se sospecha que tenga tejido neoplástico, caracterizado porque comprende los pasos de : (a) administrar una dosis inhibidora de marcador bioquímico, de un congénere de somatostatina no marcado, a un paciente; (b) vigilar un marcador bioquímico asociado con el tejido neoplástico para determinar si el congénere de somatostatina administrado reduce la presencia de dicho marcador en el paciente; (c) si se redujo la presencia vigilada del marcador en el paciente, administrar el congénere de somatostatina radiomarcado al paciente; y (d) acceder al paciente con una sonda de detención de radiación, para determinar el tejido que exhibe niveles de radiación elevados.
MX9305690A 1992-09-15 1993-09-15 Aplicacion de cinetica de peptido/receptor celular, utilizando congeneres de somatostatina radiomarcados en la detencion y la diferenciacion in situ ein vivo de tejido neoplastico. MX9305690A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94511092A 1992-09-15 1992-09-15
US08/114,675 US5590656A (en) 1992-09-15 1993-08-31 Application of peptide/cell receptor kinetics utilizing radiolabeled somatostatin congeners in the in situ, in vivo detection and differentiation of neoplastic tissue

Publications (1)

Publication Number Publication Date
MX9305690A true MX9305690A (es) 1994-05-31

Family

ID=26812444

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9305690A MX9305690A (es) 1992-09-15 1993-09-15 Aplicacion de cinetica de peptido/receptor celular, utilizando congeneres de somatostatina radiomarcados en la detencion y la diferenciacion in situ ein vivo de tejido neoplastico.

Country Status (8)

Country Link
US (1) US5590656A (es)
EP (1) EP0588754A1 (es)
JP (1) JPH07304691A (es)
KR (1) KR0150478B1 (es)
AU (1) AU668210B2 (es)
CA (1) CA2107074A1 (es)
IL (1) IL107005A (es)
MX (1) MX9305690A (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5732704A (en) * 1995-10-13 1998-03-31 Neoprobe Corporation Radiation based method locating and differentiating sentinel nodes
AT405906B (de) * 1997-03-14 1999-12-27 Irene Dr Virgolini Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
US6418338B1 (en) * 1998-02-06 2002-07-09 Phylatron Ltd. Method for detecting and surgically removing lymphoid tissue involved in tumor progression
AU3895299A (en) * 1998-05-12 1999-11-29 Wen Y Chen Use of anti-prolactin agents to treat proliferative conditions
EP1040837A3 (en) * 1999-02-26 2002-01-02 Erasmus Universiteit Rotterdam Medicaments for the treatment of a choroidal neovascularization (CNV) related disorder
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en) * 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
CA2325169A1 (en) 1999-12-03 2001-06-03 Ndsu Research Foundation Somatostatins and method
EP1381396B1 (en) * 2001-04-23 2009-04-01 Mallinckrodt Inc. Tc and re labeled radioactive glycosylated octreotide derivatives
US7094753B2 (en) * 2001-11-21 2006-08-22 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Somatostatin analog and uses thereof
US20030232016A1 (en) * 2002-04-17 2003-12-18 Russell Heinrich Nerve identification and sparing method
AU2003259172A1 (en) * 2002-07-24 2004-02-09 The Salk Institute For Biological Studies Receptor (sstr4)- selective somatostatin analogs
US8691761B2 (en) * 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
BRPI0717135B8 (pt) 2006-10-16 2021-05-25 Salk Inst Biological Studies antagonista peptídico cíclico de somastotatina e composição farmacêutica
US8475763B2 (en) * 2008-10-09 2013-07-02 Actis, Ltd. Method of determining the course of treatment for a patient having adenocarcinoma
NZ591047A (en) 2011-02-09 2013-11-29 Vladimirovich Bovin Nicolai In vivo methods of monitoring biodistribution
CN104379150A (zh) * 2012-06-21 2015-02-25 安吉奥金尼药品有限公司 缓解肿瘤症状的方法和组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782840A (en) * 1984-03-02 1988-11-08 Neoprobe Corporation Method for locating, differentiating, and removing neoplasms
US4932412A (en) * 1986-12-18 1990-06-12 Immunomedics, Inc. Intraoperative and endoscopic tumor detection and therapy
US5094837A (en) * 1990-01-22 1992-03-10 Wayne State University Method for use of magnetic resonance imaging to image pancreas using secretin
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging

Also Published As

Publication number Publication date
US5590656A (en) 1997-01-07
EP0588754A1 (en) 1994-03-23
AU4746193A (en) 1994-03-24
KR940006605A (ko) 1994-04-25
IL107005A0 (en) 1993-12-28
IL107005A (en) 1997-11-20
KR0150478B1 (ko) 1998-10-15
AU668210B2 (en) 1996-04-26
CA2107074A1 (en) 1994-03-16
JPH07304691A (ja) 1995-11-21

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