MX9302964A - Vacunas de clostridium perfringens. - Google Patents

Vacunas de clostridium perfringens.

Info

Publication number
MX9302964A
MX9302964A MX9302964A MX9302964A MX9302964A MX 9302964 A MX9302964 A MX 9302964A MX 9302964 A MX9302964 A MX 9302964A MX 9302964 A MX9302964 A MX 9302964A MX 9302964 A MX9302964 A MX 9302964A
Authority
MX
Mexico
Prior art keywords
clostridium perfringens
toxin
alpha
vaccines
present
Prior art date
Application number
MX9302964A
Other languages
English (en)
Inventor
Richard William Titball
Ethel Diane Williamson
Original Assignee
Secr Defence
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929210717A external-priority patent/GB9210717D0/en
Application filed by Secr Defence filed Critical Secr Defence
Publication of MX9302964A publication Critical patent/MX9302964A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088—Glutathione transferase (2.5.1.18)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención proporciona péptidos novedosos y vacunas que loscontienen capaces de inducir la producción de anticuerpos dirigidos contrala alfa-toxina de CLOSTRIDIUM PERFRINGENS (CPa) en animales a los cualesse les han administrado, y por lo que se proporciona profilaxis contra lainfección por CLOSTRIDIUM PERFRINGENS y/o alfa-toxina por sí misma.Particularmente, la presente invención proporciona una de tales vacunas,que es relativamente segura sencilla de producir, por ejemplo por medio dela ingeniería genética. Los péptidos preferidos comprenden la secuencia deaminoácidos de la alfa-toxina de CLOSTRIDIUM PERFRINGENS desde elaminoácido 247 al 370, pero carecen de los epítopes necesarios paraencontrar la actividad hidrolizante de la fosfolipasa y/o esfingomielinaencontrada entre los aminoácidos 1 a 240 de esa secuencia. Además, seproporcionan antisueros y anticuerpos producidos contra los péptidos yvacunas de la presente invención, y particularmente anticuerposmonoclonales y líneas celulares de hibridoma para su producción.
MX9302964A 1992-05-20 1993-05-20 Vacunas de clostridium perfringens. MX9302964A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929210717A GB9210717D0 (en) 1992-05-20 1992-05-20 Clostrdium perfringens vaccines
GB929215655A GB9215655D0 (en) 1992-05-20 1992-07-23 Clostridium perfringens vaccines

Publications (1)

Publication Number Publication Date
MX9302964A true MX9302964A (es) 1995-01-31

Family

ID=26300904

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9302964A MX9302964A (es) 1992-05-20 1993-05-20 Vacunas de clostridium perfringens.

Country Status (16)

Country Link
US (2) US5817317A (es)
EP (1) EP0642581B1 (es)
JP (1) JP3370672B2 (es)
CN (1) CN1057533C (es)
AT (1) ATE226635T1 (es)
AU (1) AU671838B2 (es)
CA (1) CA2136230C (es)
DE (1) DE69332434T2 (es)
DK (1) DK0642581T3 (es)
ES (1) ES2185631T3 (es)
GB (1) GB2283020B (es)
IL (1) IL105763A (es)
MX (1) MX9302964A (es)
NZ (1) NZ253189A (es)
PT (1) PT642581E (es)
WO (1) WO1993023543A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9605222D0 (en) * 1996-03-12 1996-05-15 Secr Defence Clostridium perfringens epsilon toxin vaccines
DE69836520T2 (de) * 1997-06-20 2007-06-06 Intervet International B.V. Clostridium perfringens Impfstoff
CA2404356A1 (en) * 2002-09-18 2004-03-18 Canadian Inovatech Inc. Gram-positive antibacterial composition and method for use
CN1984679B (zh) 2004-06-04 2013-05-15 美国政府健康及人类服务部 制备免疫原性结合物的方法
MY149604A (en) * 2005-04-18 2013-09-13 Schering Plough Ltd C.perfringens alpha toxoid vaccine
ES2545265T3 (es) * 2006-03-30 2015-09-09 Zoetis Services Llc Procedimientos y composiciones de vacunación de aves de corral
CN101489584B (zh) * 2006-04-17 2013-05-01 先灵-普劳有限公司 重组减毒梭状芽孢杆菌生物体和疫苗
US20100317084A1 (en) * 2007-05-10 2010-12-16 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacteria comprising vectors for expression of nucleic acid sequences encoding antigens
EP2150616A4 (en) 2007-05-10 2011-07-27 Univ Arizona REGULATED ANTIGEN SYNTHESIS AND / OR REGULATED ATTENUATION FOR IMPROVING VACCINATE IMMUNOGENICITY AND / OR SAFETY
WO2009046449A1 (en) * 2007-10-05 2009-04-09 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting an immune response against enteric pathogens
WO2010045620A1 (en) 2008-10-17 2010-04-22 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae
US9163219B2 (en) * 2009-04-14 2015-10-20 Arizona Board Of Regents On Behalf Of Arizona State University Single expression vector for generation of a virus with a segmented genome
WO2010135563A1 (en) 2009-05-22 2010-11-25 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium and methods of antigen and nucleic acid delivery
US9045742B2 (en) * 2009-05-29 2015-06-02 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant Edwardsiella bacterium
US9062297B2 (en) 2010-01-13 2015-06-23 The Arizona Board Of Regents For And On Behalf Of Arizona State University Yersinia pestis vaccine
US8889121B2 (en) 2010-01-22 2014-11-18 The Arizona Board Of Regents For An On Behalf Of Arizona State University Bacterium comprising a regulated rfaH nucleic acid
WO2011103465A2 (en) * 2010-02-20 2011-08-25 Alexey Gennadievich Zdanovsky Botulinum neurotoxin antigenic compositions and methods
US9598697B2 (en) 2010-05-28 2017-03-21 The Arizona Board Of Regents For And On Behalf Of Arizona State University Recombinant bacterium to decrease tumor growth
US20140234360A1 (en) 2011-09-30 2014-08-21 The United States of America, as represented by the Secretary, Dept.of Health and Human Services Influenza vaccine
US10174086B2 (en) 2011-10-25 2019-01-08 University Of Exeter Vaccine
GB201118394D0 (en) 2011-10-25 2011-12-07 Univ Exeter Vaccine
EP2830655B1 (en) 2012-03-29 2017-05-17 University of Exeter Epsilon toxin epitopes from clostridium perfringens with reduced toxicity
US9303264B2 (en) 2012-05-18 2016-04-05 The Arizona Board Of Regents For And On Behalf Of Arizona State University Photosynthetic microorganisms expressing thermostable lipase
US9580718B2 (en) 2013-06-17 2017-02-28 Arizona Board Of Regents On Behalf Of Arizona State University Attenuated live bacteria with increased acid resistance and methods of use thereof
GB201322463D0 (en) * 2013-12-18 2014-02-05 Univ Exeter Composition
CN104531730B (zh) * 2014-12-15 2018-07-17 中国人民解放军军事医学科学院军事兽医研究所 产气荚膜梭菌α毒素人源化单链抗体8B
CN104531731B (zh) * 2014-12-15 2018-06-26 中国人民解放军军事医学科学院军事兽医研究所 产气荚膜梭菌α毒素人源化单链抗体7D
EP3518968B1 (en) 2016-10-03 2022-01-05 The U.S.A. as represented by the Secretary, Department of Health and Human Services Hiv-1 env fusion peptide immunogens and their use
US11202824B2 (en) 2016-10-31 2021-12-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Peptide fragments from filoviruses and their uses
WO2018176031A1 (en) 2017-03-24 2018-09-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Glycan-masked engineered outer domains of hiv-1 gp120 and their use
CN107596361B (zh) * 2017-09-12 2020-08-14 浙江海隆生物科技有限公司 牛a型产气荚膜梭菌的亚单位疫苗及其制备方法和应用
WO2019079337A1 (en) 2017-10-16 2019-04-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services RECOMBINANT HIV-1 ENVELOPE PROTEINS AND THEIR USE
CN108904791A (zh) * 2018-07-20 2018-11-30 中国兽医药品监察所 一种产气荚膜梭菌α毒素重组亚单位疫苗及其生产方法
US20210353740A1 (en) 2018-09-23 2021-11-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Hiv-1 env fusion peptide nanoparticle carrier conjugates and their use
EP3870703A1 (en) 2018-10-22 2021-09-01 The United States of America, as represented by the Secretary, Department of Health and Human Services Recombinant gp120 protein with v1-loop deletion
CN109602898B (zh) * 2018-12-28 2022-02-22 江苏省农业科学院 一种产气荚膜梭菌α毒素基因工程疫苗及其制备方法
WO2023015186A1 (en) 2021-08-03 2023-02-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection
CN114621963A (zh) * 2022-03-11 2022-06-14 牧原食品股份有限公司 一种猪魏氏梭菌a型的亚单位疫苗及其制备
WO2023192835A1 (en) 2022-03-27 2023-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Base-covered hiv-1 envelope ectodomains and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4877612A (en) * 1985-05-20 1989-10-31 Frank M. Berger Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process
US5200318A (en) * 1992-05-13 1993-04-06 Miles Inc. Diagnosis of IDDM with a panel of immunoreagents

Also Published As

Publication number Publication date
CA2136230C (en) 2008-11-18
DE69332434T2 (de) 2003-06-26
ATE226635T1 (de) 2002-11-15
WO1993023543A1 (en) 1993-11-25
GB2283020B (en) 1996-05-01
IL105763A (en) 2005-11-20
IL105763A0 (en) 1993-09-22
DE69332434D1 (de) 2002-11-28
CN1057533C (zh) 2000-10-18
CN1084407A (zh) 1994-03-30
JP3370672B2 (ja) 2003-01-27
CA2136230A1 (en) 1993-11-25
US5817317A (en) 1998-10-06
EP0642581B1 (en) 2002-10-23
GB9422512D0 (en) 1995-01-04
ES2185631T3 (es) 2003-05-01
AU671838B2 (en) 1996-09-12
PT642581E (pt) 2003-03-31
DK0642581T3 (da) 2003-02-17
AU4334293A (en) 1993-12-13
US5851827A (en) 1998-12-22
EP0642581A1 (en) 1995-03-15
JPH07506725A (ja) 1995-07-27
NZ253189A (en) 1996-08-27
GB2283020A (en) 1995-04-26

Similar Documents

Publication Publication Date Title
MX9302964A (es) Vacunas de clostridium perfringens.
Hohlfeld et al. Human T-helper lymphocytes in myasthenia gravis recognize the nicotinic receptor alpha subunit.
Courret et al. Presentation of the Leishmania antigen LACK by infected macrophages is dependent upon the virulence of the phagocytosed parasites
Okuda et al. Protective immunity against influenza A virus induced by immunization with DNA plasmid containing influenza M gene
IL107026A0 (en) Antigen of hybrid m protein and carrier for group a streptococcal vaccine
EP0203676A3 (en) Vaccine for generating an immunogenic t cell response protective against a virus
ES2148799T3 (es) Anticuerpos monoclonales neutralizantes contra virus sincitial respiratorio.
ES2138086T3 (es) Constructo de peptido sintetico compuesto que provoca anticuerpos neutralizantes y linfocitos t citotoxicos contra hiv.
AR077576A2 (es) Un peptido de telomerasa y composiciones farmaceuticas para el tratamiento contra el cancer que comprenden tales peptidos
MX9301706A (es) Composicion de vacuna para el tratamiento de la infeccion por helicobacter.
IL104716A (en) 7-1-oxo-2- (substituted mercapto)-3- phenylpropyl) amino| octahydro-6-pyrido £2, 1-a| benzazepine- 4-carboxylic acid derivatives and analogs, their preparation and pharmaceutical compositions containing them for inhibiting enkephalinase and ace
ES2091861T3 (es) Proteinas antigenicas y vacunas que las contienen para la prevencion de la coccidiosis.
PT880360E (pt) Novos metodos de vacinacao e consequentes vacinas que compreendem um acido nucleico que codifica um primeiro epitopo e um peptido que contem um segundo epitopo
Kahl et al. Structural and antigenic characterization of a species-and promastigote-specific Leishmania mexicana amazonensis membrane protein.
Velge-Roussel et al. Epitopic analysis of the Toxoplasma gondii major surface antigen SAG1
ES551461A0 (es) Un metodo para la preparacion de una vacuna parvovirus canina.
ES2066887T3 (es) Anticuerpo monoclonal para diferenciar individuos seropositivos hiv-2 de los hiv-1.
Cordeiro da Silva et al. A 24 000 MW Trypanosoma cruzi antigen is a B‐cell activator
ZA832044B (en) Imidazolyphenyl-tetrahydropyridazines,processes for their preparation and pharmaceutical preparation containing them
King et al. The use of monoclonal antibodies specific for seal immunoglobulins in an enzyme-linked immunosorbent assay to detect canine distemper virus-specific immunoglobulin in seal plasma samples
Arce-Estrada et al. Neutralization of venom-induced hemorrhage by equine antibodies raised by immunization with a plasmid encoding a novel P-II metalloproteinase from the lancehead pitviper Bothrops asper
Voluménie et al. Induction of transient murine T cell anergy by a low molecular weight compound obtained from supernatants of human placental cultures is linked to defective phosphorylation of TCR CD3 chain
Bergmeier et al. Antibodies to human and non-human primate cellular and culture medium components in macaques vaccinated with the simian immunodeficiency virus.
US5885814A (en) Vaccine containing a serine protease
Nagata et al. Identification of epitopes associated with different biological activities on the glycoprotein of vesicular stomatitis virus by use of monoclonal antibodies