US5206018A
(en)
*
|
1978-11-03 |
1993-04-27 |
Ayerst, Mckenna & Harrison, Inc. |
Use of rapamycin in treatment of tumors
|
US6548640B1
(en)
*
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
US5221670A
(en)
*
|
1990-09-19 |
1993-06-22 |
American Home Products Corporation |
Rapamycin esters
|
US5378696A
(en)
*
|
1990-09-19 |
1995-01-03 |
American Home Products Corporation |
Rapamycin esters
|
US5321009A
(en)
*
|
1991-04-03 |
1994-06-14 |
American Home Products Corporation |
Method of treating diabetes
|
US5194447A
(en)
*
|
1992-02-18 |
1993-03-16 |
American Home Products Corporation |
Sulfonylcarbamates of rapamycin
|
US5286731A
(en)
*
|
1991-09-17 |
1994-02-15 |
American Home Products Corporation |
Method of treating immunoinflammatory bowel disease
|
US5286730A
(en)
*
|
1991-09-17 |
1994-02-15 |
American Home Products Corporation |
Method of treating immunoinflammatory disease
|
US5164399A
(en)
*
|
1991-11-18 |
1992-11-17 |
American Home Products Corporation |
Rapamycin pyrazoles
|
CA2086642C
(en)
*
|
1992-01-09 |
2004-06-15 |
Randall E. Morris |
Method of treating hyperproliferative vascular disease
|
US5516781A
(en)
*
|
1992-01-09 |
1996-05-14 |
American Home Products Corporation |
Method of treating restenosis with rapamycin
|
US5262424A
(en)
*
|
1992-02-18 |
1993-11-16 |
American Home Products Corporation |
Composition of sulfonylcarbamates of rapamycin and method of treating diseases requiring immunosuppression therewith
|
US5177203A
(en)
*
|
1992-03-05 |
1993-01-05 |
American Home Products Corporation |
Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
|
DE69302945T2
(de)
|
1992-03-27 |
1996-10-10 |
American Home Prod |
29-Demethoxyrapamycin zur Induktion der Immunosuppression
|
US5288711A
(en)
*
|
1992-04-28 |
1994-02-22 |
American Home Products Corporation |
Method of treating hyperproliferative vascular disease
|
US5256790A
(en)
*
|
1992-08-13 |
1993-10-26 |
American Home Products Corporation |
27-hydroxyrapamycin and derivatives thereof
|
CA2106034A1
(en)
*
|
1992-09-24 |
1994-03-25 |
Ralph J. Russo |
21-norrapamycin
|
US5302584A
(en)
*
|
1992-10-13 |
1994-04-12 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5434260A
(en)
*
|
1992-10-13 |
1995-07-18 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5489680A
(en)
*
|
1992-10-13 |
1996-02-06 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5480988A
(en)
*
|
1992-10-13 |
1996-01-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5480989A
(en)
*
|
1992-10-13 |
1996-01-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5262423A
(en)
*
|
1992-10-29 |
1993-11-16 |
American Home Products Corporation |
Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents
|
US5260300A
(en)
*
|
1992-11-19 |
1993-11-09 |
American Home Products Corporation |
Rapamycin carbonate esters as immuno-suppressant agents
|
US5482945A
(en)
*
|
1992-12-22 |
1996-01-09 |
American Home Products Corporation |
Innovative technique for immunosuppression involving administration of rapamycin loaded formed blood elements
|
US5349060A
(en)
*
|
1993-01-07 |
1994-09-20 |
American Home Products Corporation |
Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents
|
US5252579A
(en)
*
|
1993-02-16 |
1993-10-12 |
American Home Products Corporation |
Macrocyclic immunomodulators
|
US5504091A
(en)
*
|
1993-04-23 |
1996-04-02 |
American Home Products Corporation |
Biotin esters of rapamycin
|
DE69435044T2
(de)
|
1993-04-23 |
2008-09-18 |
Wyeth |
Rapamycin - Konjugate und Antikörper
|
US7279561B1
(en)
|
1993-04-23 |
2007-10-09 |
Wyeth |
Anti-rapamycin monoclonal antibodies
|
US5387680A
(en)
*
|
1993-08-10 |
1995-02-07 |
American Home Products Corporation |
C-22 ring stabilized rapamycin derivatives
|
US5391730A
(en)
*
|
1993-10-08 |
1995-02-21 |
American Home Products Corporation |
Phosphorylcarbamates of rapamycin and oxime derivatives thereof
|
US5373014A
(en)
*
|
1993-10-08 |
1994-12-13 |
American Home Products Corporation |
Rapamycin oximes
|
US5378836A
(en)
*
|
1993-10-08 |
1995-01-03 |
American Home Products Corporation |
Rapamycin oximes and hydrazones
|
US5385909A
(en)
*
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Heterocyclic esters of rapamycin
|
US5385910A
(en)
*
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Gem-distributed esters of rapamycin
|
US5385908A
(en)
*
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Hindered esters of rapamycin
|
US5389639A
(en)
*
|
1993-12-29 |
1995-02-14 |
American Home Products Company |
Amino alkanoic esters of rapamycin
|
US5525610A
(en)
*
|
1994-03-31 |
1996-06-11 |
American Home Products Corporation |
42-Epi-rapamycin and pharmaceutical compositions thereof
|
US5362718A
(en)
|
1994-04-18 |
1994-11-08 |
American Home Products Corporation |
Rapamycin hydroxyesters
|
US5463048A
(en)
*
|
1994-06-14 |
1995-10-31 |
American Home Products Corporation |
Rapamycin amidino carbamates
|
US5491231A
(en)
*
|
1994-11-28 |
1996-02-13 |
American Home Products Corporation |
Hindered N-oxide esters of rapamycin
|
US5563145A
(en)
*
|
1994-12-07 |
1996-10-08 |
American Home Products Corporation |
Rapamycin 42-oximes and hydroxylamines
|
US5561138A
(en)
*
|
1994-12-13 |
1996-10-01 |
American Home Products Corporation |
Method of treating anemia
|
US5496832A
(en)
*
|
1995-03-09 |
1996-03-05 |
American Home Products Corporation |
Method of treating cardiac inflammatory disease
|
FR2736550B1
(fr)
|
1995-07-14 |
1998-07-24 |
Sandoz Sa |
Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
|
TW427904B
(en)
*
|
1995-12-07 |
2001-04-01 |
American Home Prod |
Neuroprotective agents
|
US5780462A
(en)
|
1995-12-27 |
1998-07-14 |
American Home Products Corporation |
Water soluble rapamycin esters
|
US5922730A
(en)
*
|
1996-09-09 |
1999-07-13 |
American Home Products Corporation |
Alkylated rapamycin derivatives
|
IT1289815B1
(it)
*
|
1996-12-30 |
1998-10-16 |
Sorin Biomedica Cardio Spa |
Stent per angioplastica e relativo procedimento di produzione
|
US6015809A
(en)
*
|
1998-08-17 |
2000-01-18 |
American Home Products Corporation |
Photocyclized rapamycin
|
US6331547B1
(en)
|
1999-08-18 |
2001-12-18 |
American Home Products Corporation |
Water soluble SDZ RAD esters
|
WO2001068133A1
(en)
*
|
2000-03-14 |
2001-09-20 |
Genetics Institute, Inc. |
Use of rapamycin and agents that inhibit b7 activity in immunomodulation
|
US6670355B2
(en)
|
2000-06-16 |
2003-12-30 |
Wyeth |
Method of treating cardiovascular disease
|
EP1319008B1
(en)
|
2000-09-19 |
2008-10-15 |
Wyeth |
Water soluble rapamycin esters
|
US6399625B1
(en)
|
2000-09-27 |
2002-06-04 |
Wyeth |
1-oxorapamycins
|
US6440991B1
(en)
|
2000-10-02 |
2002-08-27 |
Wyeth |
Ethers of 7-desmethlrapamycin
|
US6399626B1
(en)
|
2000-10-02 |
2002-06-04 |
Wyeth |
Hydroxyesters of 7-desmethylrapamycin
|
TWI286074B
(en)
|
2000-11-15 |
2007-09-01 |
Wyeth Corp |
Pharmaceutical composition containing CCI-779 as an antineoplastic agent
|
TWI296196B
(en)
*
|
2001-04-06 |
2008-05-01 |
Wyeth Corp |
Antineoplastic combinations
|
TWI233359B
(en)
*
|
2001-04-06 |
2005-06-01 |
Wyeth Corp |
Pharmaceutical composition for treating neoplasm
|
ZA200603888B
(en)
*
|
2001-06-01 |
2007-05-30 |
Wyeth Corp |
Antineoplastic combinations
|
UA77200C2
(en)
|
2001-08-07 |
2006-11-15 |
Wyeth Corp |
Antineoplastic combination of cci-779 and bkb-569
|
CA2455308A1
(en)
|
2001-08-22 |
2003-03-06 |
Wyeth |
Rapamycin 29-enols
|
CA2455311A1
(en)
|
2001-08-22 |
2003-03-06 |
Wyeth |
Rapamycin dialdehydes
|
RU2344821C2
(ru)
|
2002-07-30 |
2009-01-27 |
Уайт |
Парентеральные композиции, содержащие гидроксиэфиры рапамицина
|
CN100415233C
(zh)
*
|
2002-09-17 |
2008-09-03 |
惠氏公司 |
口服制剂
|
PT1539157E
(pt)
|
2002-09-18 |
2013-10-04 |
Univ Pennsylvania |
Rapamicina para utilização na inibição ou prevenção de neovascularização coroidal
|
AU2003301348A1
(en)
*
|
2002-10-18 |
2004-05-04 |
Wyeth |
Compositions and methods for diagnosing and treating autoimmune disease
|
AR042938A1
(es)
*
|
2003-02-06 |
2005-07-06 |
Wyeth Corp |
Uso del cci-779 en el tratamiento de la fibrosis hepatica
|
UA83484C2
(uk)
*
|
2003-03-05 |
2008-07-25 |
Уайт |
Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
|
BRPI0409632A
(pt)
*
|
2003-04-22 |
2006-04-25 |
Wyeth Corp |
combinações antineoplásticas
|
US7585517B2
(en)
*
|
2003-09-18 |
2009-09-08 |
Macusight, Inc. |
Transscleral delivery
|
DE602005010228D1
(de)
*
|
2004-04-14 |
2008-11-20 |
Wyeth Corp |
Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper
|
EP1768662A2
(en)
|
2004-06-24 |
2007-04-04 |
Novartis Vaccines and Diagnostics, Inc. |
Small molecule immunopotentiators and assays for their detection
|
KR20070083941A
(ko)
*
|
2004-10-04 |
2007-08-24 |
큐엘티 유에스에이, 인코포레이티드 |
중합체 전달 조성을 갖는 눈 전달
|
US8313763B2
(en)
*
|
2004-10-04 |
2012-11-20 |
Tolmar Therapeutics, Inc. |
Sustained delivery formulations of rapamycin compounds
|
BRPI0608152A2
(pt)
|
2005-02-09 |
2009-11-10 |
Macusight Inc |
formulações para tratamento ocular
|
US8663639B2
(en)
*
|
2005-02-09 |
2014-03-04 |
Santen Pharmaceutical Co., Ltd. |
Formulations for treating ocular diseases and conditions
|
JP2008530145A
(ja)
*
|
2005-02-15 |
2008-08-07 |
ワイス |
経口投与可能なcci−779製剤
|
CN101360495B
(zh)
|
2005-11-14 |
2012-03-14 |
阿里亚德医药股份有限公司 |
对癌症病人给药mTOR抑制剂
|
WO2007092620A2
(en)
|
2006-02-09 |
2007-08-16 |
Macusight, Inc. |
Stable formulations, and methods of their preparation and use
|
CA2645488C
(en)
*
|
2006-03-23 |
2014-09-02 |
Macusight, Inc. |
Formulations comprising rapamycin and methods using same for vascular permeability-related diseases or conditions
|
RU2010104916A
(ru)
*
|
2006-08-16 |
2011-08-20 |
Михаил В. Благосклонный (US) |
Способ профилактики и лечения возрастных заболеваний
|
CA2660690A1
(en)
*
|
2006-08-22 |
2008-02-28 |
Novartis Ag |
Treatment of fibrosing disorders
|
US7867988B2
(en)
|
2006-09-13 |
2011-01-11 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
US20080265343A1
(en)
*
|
2007-04-26 |
2008-10-30 |
International Business Machines Corporation |
Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof
|
BRPI0919794A2
(pt)
*
|
2008-10-03 |
2015-12-15 |
Elixir Medical Corp |
dispositivo para uso intracorpóreo, e, composto
|
CA2937492C
(en)
|
2008-11-11 |
2019-08-13 |
The Board Of Regents Of The University Of Texas System |
Inhibition of mammalian target of rapamycin
|
EA023244B1
(ru)
*
|
2009-04-10 |
2016-05-31 |
Хаян Ки |
Способ предотвращения старения клеток
|
US9283211B1
(en)
|
2009-11-11 |
2016-03-15 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
EP2906214A1
(en)
|
2012-10-12 |
2015-08-19 |
The Board of Regents of The University of Texas System |
Use of mtor inhibitors to treat vascular cognitive impairment
|
WO2014160328A1
(en)
|
2013-03-13 |
2014-10-02 |
The Board Of Regents Of The University Of Texas System |
Mtor inhibitors for prevention of intestinal polyp growth
|
US9700544B2
(en)
|
2013-12-31 |
2017-07-11 |
Neal K Vail |
Oral rapamycin nanoparticle preparations
|
ES2900426T3
(es)
|
2013-12-31 |
2022-03-16 |
Rapamycin Holdings Llc |
Preparaciones orales y uso de nanopartículas de rapamicina
|