MX391445B - Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato. - Google Patents

Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.

Info

Publication number
MX391445B
MX391445B MX2018010998A MX2018010998A MX391445B MX 391445 B MX391445 B MX 391445B MX 2018010998 A MX2018010998 A MX 2018010998A MX 2018010998 A MX2018010998 A MX 2018010998A MX 391445 B MX391445 B MX 391445B
Authority
MX
Mexico
Prior art keywords
methyl
ylethynyl
pyridazin
methylpiperazin
imidazo
Prior art date
Application number
MX2018010998A
Other languages
English (en)
Spanish (es)
Inventor
Christopher K Murray
John J Chaber
Leonard W Rozamus
Pradeep Sharma
Original Assignee
Ariad Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50929140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX391445(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ariad Pharma Inc filed Critical Ariad Pharma Inc
Publication of MX391445B publication Critical patent/MX391445B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MX2018010998A 2012-12-12 2013-12-12 Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato. MX391445B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261736543P 2012-12-12 2012-12-12
US201261737007P 2012-12-13 2012-12-13
US201361788208P 2013-03-15 2013-03-15
PCT/US2013/074571 WO2014093579A2 (en) 2012-12-12 2013-12-12 Crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl)benzamide and its mono hydrochloride salt

Publications (1)

Publication Number Publication Date
MX391445B true MX391445B (es) 2025-03-21

Family

ID=50929140

Family Applications (11)

Application Number Title Priority Date Filing Date
MX2018010998A MX391445B (es) 2012-12-12 2013-12-12 Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2015007578A MX359147B (es) 2012-12-12 2013-12-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3-iletinil)-4-me til-n-(4-[ (4-metilpiperazin-1-il) metil]-3-(trifluorometil) fenil) benzamida y su sal de monoclorhidrato.
MX2021002258A MX2021002258A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002254A MX2021002254A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002261A MX2021002261A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002257A MX2021002257A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002255A MX2021002255A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002256A MX2021002256A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002259A MX2021002259A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002264A MX2021002264A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002253A MX2021002253A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.

Family Applications After (10)

Application Number Title Priority Date Filing Date
MX2015007578A MX359147B (es) 2012-12-12 2013-12-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3-iletinil)-4-me til-n-(4-[ (4-metilpiperazin-1-il) metil]-3-(trifluorometil) fenil) benzamida y su sal de monoclorhidrato.
MX2021002258A MX2021002258A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002254A MX2021002254A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002261A MX2021002261A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002257A MX2021002257A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002255A MX2021002255A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002256A MX2021002256A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002259A MX2021002259A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002264A MX2021002264A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
MX2021002253A MX2021002253A (es) 2012-12-12 2015-06-12 Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.

Country Status (9)

Country Link
US (9) US9493470B2 (cg-RX-API-DMAC7.html)
JP (4) JP6447508B2 (cg-RX-API-DMAC7.html)
CN (2) CN105188701A (cg-RX-API-DMAC7.html)
CA (3) CA3167093A1 (cg-RX-API-DMAC7.html)
CL (1) CL2015001643A1 (cg-RX-API-DMAC7.html)
HK (1) HK1218878A1 (cg-RX-API-DMAC7.html)
MX (11) MX391445B (cg-RX-API-DMAC7.html)
NZ (1) NZ709648A (cg-RX-API-DMAC7.html)
WO (2) WO2014093583A2 (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2495016T3 (da) 2005-12-23 2019-12-16 Ariad Pharma Inc Bicykliske heteroarylforbindelser
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
CA3167093A1 (en) 2012-12-12 2014-06-12 Ariad Pharmaceuticals, Inc. Crystalline form c of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride
AU2014286047B2 (en) 2013-07-04 2018-02-08 Sandoz Ag Crystalline forms of ponatinib hydrochloride
CN104496940B (zh) * 2014-01-06 2017-03-15 广东东阳光药业有限公司 一种制备bcr‑abl抑制剂中间体的方法
CA3047107A1 (en) * 2016-12-15 2018-06-21 Ariad Pharmaceuticals, Inc. Benzimidazole compounds as c-kit inhibitors
US10221184B2 (en) 2017-01-20 2019-03-05 Apicore Us Llc Polymorphs of ponatinib hydrochloride
WO2018232501A1 (en) * 2017-06-20 2018-12-27 Apotex Inc. Crystalline forms of ponatinib hydrochloride
KR20250010134A (ko) * 2018-04-02 2025-01-20 스텔스 바이오테라퓨틱스 인코포레이티드 엘라미프레티드의 합성에 유용한 결정질 디펩티드
WO2019246479A1 (en) * 2018-06-22 2019-12-26 Johnson Matthey Public Limited Company Form of ponatinib
CA3118330A1 (en) 2018-11-01 2020-05-07 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2020223235A1 (en) 2019-04-29 2020-11-05 Incyte Corporation Mini-tablet dosage forms of ponatinib
CN111004240B (zh) * 2019-12-13 2020-12-01 山东铂源药业有限公司 一种泊那替尼中间体3-乙炔基咪唑并[1,2-b]哒嗪的合成方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5099067A (en) 1988-08-05 1992-03-24 Northwestern University Use of ammonium formate as a hydrogen transfer reagent for reduction of chiral nitro compounds with retention of configuration
EP1230231B1 (en) 1999-11-08 2005-06-22 Schering Corporation Process for preparing n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperazine
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
DE10021246A1 (de) 2000-04-25 2001-10-31 Schering Ag Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel
IL159811A0 (en) 2001-07-13 2004-06-20 Neurogen Corp Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands
AR041992A1 (es) 2002-11-06 2005-06-08 Smithkline Beecham Corp Compuesto de piridinil benzoheterociclico, composicion farmaceutica que lo comprende y su uso para prepararla
GB0230089D0 (en) 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
WO2005051366A2 (en) 2003-11-28 2005-06-09 Novartis Ag Diaryl urea derivatives in the treatment of protein kinase dependent diseases
EP1694691A1 (en) 2003-12-05 2006-08-30 Biovitrum Ab Improved synthesis of 2-substituted adenosines
WO2005060969A1 (en) 2003-12-24 2005-07-07 Astrazeneca Ab Pyrimidines with tie2 (tek) activity
ES2317079T3 (es) 2003-12-24 2009-04-16 Astrazeneca Ab Pirimidinas con actividad tie2 (tek).
EA011930B1 (ru) 2004-04-07 2009-06-30 Лаборатуар Сероно Са Карбоновые кислоты
JP2008506702A (ja) 2004-07-14 2008-03-06 ピーティーシー セラピューティクス，インコーポレーテッド Ｃ型肝炎を治療するための方法
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
GB0502418D0 (en) 2005-02-05 2005-03-16 Astrazeneca Ab Compounds
JP2008534565A (ja) 2005-03-31 2008-08-28 アストラゼネカ アクチボラグ Ｔｉｅ２阻害活性のあるアミノピリミジン誘導体
JP2009502734A (ja) 2005-07-29 2009-01-29 アステラス製薬株式会社 Ｌｃｋ阻害剤としての縮合複素環
JP5321061B2 (ja) 2005-08-11 2013-10-23 アリアド・ファーマシューティカルズ・インコーポレイテッド 不飽和複素環誘導体
DK2495016T3 (da) 2005-12-23 2019-12-16 Ariad Pharma Inc Bicykliske heteroarylforbindelser
SI1973545T1 (sl) * 2005-12-23 2013-04-30 Ariad Pharmaceuticals, Inc. Spojine bicikličnega heteroarila
MX2008014290A (es) 2006-05-08 2008-11-26 Ariad Pharma Inc Compuestos heteroarilicos monociclicos.
BRPI0710328A2 (pt) 2006-05-08 2011-08-09 Ariad Pharma Inc composto da fórmula i, um tautomer da mesma, ou um sal farmaceuticamente aceitável, hidrato ou outro solvato do mesmo e método para o tratamento de cáncer em um mamìfero necessitado do mesmo e composição
EP2107054A1 (en) 2008-04-01 2009-10-07 Università Degli Studi Di Milano - Bicocca Antiproliferative compounds and therapeutic uses thereof
US20100273772A1 (en) * 2009-04-23 2010-10-28 Wyeth Llc Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5)
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
EA201290255A1 (ru) * 2009-10-30 2013-04-30 Ариад Фармасьютикалз, Инк. Способы и композиции для лечения рака
EP2694064A1 (en) * 2011-04-07 2014-02-12 Ariad Pharmaceuticals, Incorporated Methods and compositions for treating neurodegenerative diseases
KR20140022062A (ko) 2011-04-07 2014-02-21 어리어드 파마슈티칼스, 인코포레이티드 파킨슨병을 치료하기 위한 방법 및 조성물
US20150105377A1 (en) 2012-04-25 2015-04-16 Ariad Pharmaceuticals, Inc. Methods and Compositions for RAF Kinase Mediated Diseases
CA3167093A1 (en) * 2012-12-12 2014-06-12 Ariad Pharmaceuticals, Inc. Crystalline form c of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride

Also Published As

Publication number Publication date
MX2015007578A (es) 2016-03-21
US20170190707A1 (en) 2017-07-06
HK1218878A1 (zh) 2017-03-17
CA2815506A1 (en) 2014-06-12
WO2014093583A3 (en) 2014-08-07
WO2014093583A2 (en) 2014-06-19
JP7042175B2 (ja) 2022-03-25
US11192897B2 (en) 2021-12-07
MX2021002256A (es) 2021-05-27
JP2018168191A (ja) 2018-11-01
MX2021002264A (es) 2021-05-27
JP2016503010A (ja) 2016-02-01
JP7352841B2 (ja) 2023-09-29
US9493470B2 (en) 2016-11-15
MX2021002253A (es) 2021-05-27
US20210277012A1 (en) 2021-09-09
US20190169196A1 (en) 2019-06-06
MX2021002257A (es) 2021-05-27
CN105188701A (zh) 2015-12-23
US11192896B2 (en) 2021-12-07
US20150315194A1 (en) 2015-11-05
JP2023179498A (ja) 2023-12-19
US20210340149A1 (en) 2021-11-04
JP6447508B2 (ja) 2019-01-09
CL2015001643A1 (es) 2015-10-02
US11279705B2 (en) 2022-03-22
US10125136B2 (en) 2018-11-13
CA2815506C (en) 2018-12-11
NZ709648A (en) 2020-05-29
MX2021002261A (es) 2021-05-27
US10662197B2 (en) 2020-05-26
WO2014093579A2 (en) 2014-06-19
JP2022037122A (ja) 2022-03-08
US11384086B2 (en) 2022-07-12
CA3022250A1 (en) 2014-06-12
WO2014093579A3 (en) 2014-07-10
MX2021002254A (es) 2021-05-27
US20210024527A1 (en) 2021-01-28
US11192895B2 (en) 2021-12-07
MX2021002258A (es) 2021-05-27
CN115043843A (zh) 2022-09-13
US20210277011A1 (en) 2021-09-09
US20210277010A1 (en) 2021-09-09
MX2021002255A (es) 2021-05-27
MX2021002259A (es) 2021-05-27
MX359147B (es) 2018-09-17
CA3167093A1 (en) 2014-06-12
US20240083902A1 (en) 2024-03-14

Similar Documents

Publication Publication Date Title
MX391445B (es) Formas cristalinas de 3-(imidazol[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
CL2014000492A1 (es) Compuestos derivados de n-[3-(1,2,4-oxadiazol-(5-il/amino/carbamoil)fenil]imidazo[1,2-a]pirdina-3-carboxamida, inhibidores de la quinasa c-kit; composicion farmaceutica; y su uso para el tratamiento de la enfermedad de alzheimer, artritis, aterosclerosis, entre otras
NI201200072A (es) Métodos y composiciones para tratar cáncer
SMT201300098B (it) Forme solide di N-(4-(7-azabiciclo[2.2.1]eptan-7-il)-2-(trifluorometil)fenil-4-osso-5-trifluorometil)-1,4-diidrochinolina-3-carbossammide
MX374541B (es) Sales de clorhidrato de n-(cianometil)-4-(2-(4-morfolinofenilamino) pirimidin-4-il)benzamida.
EP2897615A4 (en) PHARMACOKINETIC FORMULATIONS OF DEUTERATED BENZOCHINOL INHIBITORS OF THE VESICLE MONOAMINE TRANSPORTER 2
UY34220A (es) Indazoles, composiciones farmacéuticas y uso de los mismos
NI201500142A (es) Derivados de 3-acetilamino-1 (fenil-heteroaril-aminocarbonil o fenil-heteroaril-carbonilamino) benceno para el tratamiento de desordenes hiperproliferativos.
PE20160287A1 (es) Inhibidores cristalinos de bromodominos
PE20151794A1 (es) Compuestos de 1,3-oxazin-2-amina fusionados con ciclopropilo perfluorado como inhibidores de beta-secretasa y metodos de uso
UA112317C2 (uk) Похідні 2-(1,2,3-триазол-2-іл)бензаміду та 3-(1,2,3-триазол-2-іл)піколінаміду як антагоністи рецептора орексину
UY35535A (es) ?Derivados de fenil sulfonamidas?.
EA201200728A1 (ru) Новые сокристаллы агомелатина, способ их получения и фармацевтические композиции, которые их содержат
EA201400822A1 (ru) Производные гетероциклических амидов в качестве антагонистов p2xрецептора
EA201690390A1 (ru) Производные амидов в качестве антагонистов рецептора к лизофосфатидной кислоте
EA201492054A1 (ru) Амиды 2-амино-4-арилтиазольных соединений и их соли
EA201492029A1 (ru) N-этил-4-гидроксил-1-метил-5-(метил(2,3,4,5,6-пентагидроксигексил)амино)-2-оксо-n-фенил-1,2-дигидрохинолин-3-карбоксамид
UY35536A (es) ?derivados de sulfonamida?.
EA201591717A1 (ru) Твердые формы гидрохлорида вемурафениба
UA113540C2 (xx) Поліморфи n-(2-метоксибензоїл)-4-$(метиламінокарбоніл)аміно]бензолсульфонаміду
CL2012001500A1 (es) Procedimiento de preparacion de hidrocloruro de 4-{3-[cis-hexahidrociclopenta [c]pirrol-2(1h)-il]propoxi}benzamida; formas cristalinas de la base libre y del hidrocloruro; compuestos intermediarios; composiciones farmaceuticas que los contienen; y su uso en el tratamiento de trastornos cognitivos y enfermedades neurodegenerativas.
UY37778A (es) NUEVA SAL DE N-(2,6-DIETILFENIL)-8-({4-[4-(DIMETILAMINO)PIPERIDIN-1-IL]-2- METOXIFENIL}AMINO)-1-METIL-4,5-DIHIDRO- 1H-PIRAZOLO[4,3-h]QUINAZOLINA-3- CARBOXAMIDA, SU PREPARACIÓN, Y LAS FORMULACIONES QUE LA CONTIENEN
BR112018013356A2 (pt) sal de cloridrato, formas cristalinas de um sal de cloridrato e composição farmacêutica
BR112014009217A2 (pt) antibacterianos à base de fenicol
DOP2016000322A (es) N-(cianometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida