MX390718B - Inhibidores de aminopeptidasa a y composiciones farmacéuticas que comprenden el mismo. - Google Patents

Inhibidores de aminopeptidasa a y composiciones farmacéuticas que comprenden el mismo.

Info

Publication number
MX390718B
MX390718B MX2021004741A MX2021004741A MX390718B MX 390718 B MX390718 B MX 390718B MX 2021004741 A MX2021004741 A MX 2021004741A MX 2021004741 A MX2021004741 A MX 2021004741A MX 390718 B MX390718 B MX 390718B
Authority
MX
Mexico
Prior art keywords
compound
same
aminopeptidase
inhibitors
pharmaceutical compositions
Prior art date
Application number
MX2021004741A
Other languages
English (en)
Other versions
MX2021004741A (es
Inventor
Catherine Llorens-Cortes
Delphine Compere
Fabrice Balavoine
Yannick Marc
Original Assignee
Quantum Genomics
Centre Nat Rech Scient
College France
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Genomics, Centre Nat Rech Scient, College France, Inst Nat Sante Rech Med filed Critical Quantum Genomics
Publication of MX2021004741A publication Critical patent/MX2021004741A/es
Publication of MX390718B publication Critical patent/MX390718B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/306—Arylalkanephosphinic acids, e.g. Ar-(CH2)n-P(=X)(R)(XH), (X = O,S, Se; n>=1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3264—Esters with hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C07F9/65306—Five-membered rings containing two nitrogen atoms
    • C07F9/65312—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención actual se refiere a un nuevo compuesto, a una composición que lo comprende, a métodos para preparar el compuesto y al uso de este compuesto en terapia. En particular, la invención actual se refiere a un compuesto que es útil en el tratamiento y prevención de hipertensión arterial primaria y secundaria, accidente cerebrovascular, isquemia miocárdica, insuficiencia cardíaca y renal, infarto de miocardio, enfermedad vascular periférica, proteinuria diabética, síndrome X y glaucoma.
MX2021004741A 2018-10-26 2019-10-25 Inhibidores de aminopeptidasa a y composiciones farmacéuticas que comprenden el mismo. MX390718B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18306396 2018-10-26
PCT/EP2019/079229 WO2020084131A1 (en) 2018-10-26 2019-10-25 Aminopeptidase a inhibitors and pharmaceutical compositions comprising the same

Publications (2)

Publication Number Publication Date
MX2021004741A MX2021004741A (es) 2022-03-16
MX390718B true MX390718B (es) 2025-03-21

Family

ID=64267736

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021004741A MX390718B (es) 2018-10-26 2019-10-25 Inhibidores de aminopeptidasa a y composiciones farmacéuticas que comprenden el mismo.

Country Status (15)

Country Link
US (1) US11192907B2 (es)
EP (1) EP3870591A1 (es)
JP (1) JP7051009B2 (es)
KR (1) KR102380042B1 (es)
CN (1) CN113166182A (es)
AR (1) AR116853A1 (es)
AU (1) AU2019365119B2 (es)
BR (1) BR112021007116A2 (es)
CA (1) CA3112851C (es)
EA (1) EA202191150A1 (es)
IL (1) IL282591B (es)
MX (1) MX390718B (es)
TW (1) TW202029962A (es)
WO (1) WO2020084131A1 (es)
ZA (1) ZA202103580B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113166180A (zh) * 2018-10-26 2021-07-23 量子基因公司 新的氨基次膦衍生物作为氨肽酶a抑制剂
TW202207917A (zh) * 2020-05-06 2022-03-01 法商量子基因科技有限公司 包含腦胺肽酶抑制劑、利尿劑及全身性腎素－血管收縮素系統阻斷劑之醫藥組合物
CN115385789B (zh) * 2022-09-19 2024-06-04 安徽大学 一种4-氧代丁酸甲酯的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2773712B1 (fr) * 1998-01-16 2000-06-02 Inst Nat Sante Rech Med Composition pharmaceutique comprenant au moins un inhibiteur de l'aminopeptidase a
ES2369256T3 (es) * 2000-06-26 2011-11-28 Helen Of Troy Limited Sistema de lámpara recargable.
AR058296A1 (es) * 2005-12-09 2008-01-30 Kalypsys Inc Inhibidores de histona desacetilasa y composicion farmaceutica
US20080146524A1 (en) 2006-12-14 2008-06-19 Solvay Pharmaceuticals B.V. Selective inhibitors of neurotensin degrading enzymes
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
CN113166180A (zh) 2018-10-26 2021-07-23 量子基因公司 新的氨基次膦衍生物作为氨肽酶a抑制剂

Also Published As

Publication number Publication date
IL282591A (en) 2021-06-30
ZA202103580B (en) 2022-08-31
JP7051009B2 (ja) 2022-04-08
CA3112851A1 (en) 2020-04-30
US11192907B2 (en) 2021-12-07
WO2020084131A1 (en) 2020-04-30
IL282591B (en) 2022-08-01
US20210309678A1 (en) 2021-10-07
AU2019365119B2 (en) 2021-07-29
TW202029962A (zh) 2020-08-16
EP3870591A1 (en) 2021-09-01
JP2021535189A (ja) 2021-12-16
EA202191150A1 (ru) 2021-07-15
CN113166182A (zh) 2021-07-23
BR112021007116A2 (pt) 2021-07-20
MX2021004741A (es) 2022-03-16
CA3112851C (en) 2023-01-24
AR116853A1 (es) 2021-06-23
KR102380042B1 (ko) 2022-03-28
AU2019365119A1 (en) 2021-04-15
KR20210079336A (ko) 2021-06-29

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