MX387331B - Composiciones y metodos para induccion de celulas th17. - Google Patents
Composiciones y metodos para induccion de celulas th17.Info
- Publication number
- MX387331B MX387331B MX2016013247A MX2016013247A MX387331B MX 387331 B MX387331 B MX 387331B MX 2016013247 A MX2016013247 A MX 2016013247A MX 2016013247 A MX2016013247 A MX 2016013247A MX 387331 B MX387331 B MX 387331B
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- induction
- compositions
- methods
- bacteria
- Prior art date
Links
- 230000006698 induction Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 241000894006 Bacteria Species 0.000 abstract 2
- 210000000068 Th17 cell Anatomy 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000002924 anti-infective effect Effects 0.000 abstract 1
- 229960005475 antiinfective agent Drugs 0.000 abstract 1
- 230000002550 fecal effect Effects 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a cepas de bacterias derivadas de humanos a partir de muestras fecales complejas y se ha mostrado que inducen acumulación de células Th17 en el intestino y promueven funciones inmunes. Las composiciones farmacéuticas que contienen estas bacterias pueden ser usadas como anti-infecciosas y como auxiliares en vacunas mucosas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461978182P | 2014-04-10 | 2014-04-10 | |
| PCT/JP2015/061771 WO2015156419A1 (en) | 2014-04-10 | 2015-04-10 | Compositions and methods for induction of th17 cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016013247A MX2016013247A (es) | 2017-05-03 |
| MX387331B true MX387331B (es) | 2025-03-18 |
Family
ID=54287989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016013247A MX387331B (es) | 2014-04-10 | 2015-04-10 | Composiciones y metodos para induccion de celulas th17. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10300137B2 (es) |
| EP (1) | EP3129035B1 (es) |
| JP (2) | JP6617935B2 (es) |
| KR (1) | KR102377396B1 (es) |
| CN (1) | CN106659746A (es) |
| AU (2) | AU2015244700B2 (es) |
| CA (1) | CA2944846C (es) |
| MX (1) | MX387331B (es) |
| WO (1) | WO2015156419A1 (es) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| WO2011151941A1 (ja) | 2010-06-04 | 2011-12-08 | 国立大学法人東京大学 | 制御性t細胞の増殖または集積を誘導する作用を有する組成物 |
| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| ES2993669T3 (en) | 2011-12-01 | 2025-01-03 | Univ Tokyo | Human-derived bacteria that induce proliferation or accumulation of regulatory t cells |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| JP6617935B2 (ja) | 2014-04-10 | 2019-12-11 | 国立研究開発法人理化学研究所 | Th17細胞の誘導のための組成物及び方法 |
| LT3065748T (lt) | 2014-12-23 | 2018-03-12 | 4D Pharma Research Limited | Bacteroides thetaiotaomicron padermė ir jos panaudojimas uždegimo sumažinimui |
| EP3193901B1 (en) | 2014-12-23 | 2018-04-04 | 4D Pharma Research Limited | Pirin polypeptide and immune modulation |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| SG10201912323VA (en) | 2015-06-15 | 2020-02-27 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| PL3307288T3 (pl) | 2015-06-15 | 2019-12-31 | 4D Pharma Research Limited | Kompozycje zawierające szczepy bakteryjne |
| SMT202200174T1 (it) * | 2015-06-15 | 2022-05-12 | 4D Pharma Res Limited | Composizioni comprendenti ceppi batterici |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| HK1254843B (zh) | 2015-11-20 | 2020-04-17 | 希杰生物科技株式会社 | 包含细菌菌株的组合物 |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| EP3520801A1 (en) | 2016-03-04 | 2019-08-07 | 4D Pharma Plc | Compositions comprising bacterial blautia strains for treating visceral hypersensitivity |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| US11260083B2 (en) | 2016-03-15 | 2022-03-01 | The Regents Of The University Of Michigan | Compositions and methods for treating and preventing graft versus host disease |
| CN110545828A (zh) | 2016-04-19 | 2019-12-06 | 基因组研究有限公司 | 细菌疗法 |
| WO2017218680A1 (en) | 2016-06-14 | 2017-12-21 | Vedanta Biosciences, Inc. | Treatment of clostridium difficile infection |
| US9999641B2 (en) | 2016-06-14 | 2018-06-19 | Vedanta Biosciences, Inc. | Treatment of clostridium difficile infection |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商4D製藥有限公司 | 包含細菌菌株之組合物 |
| JP7542946B2 (ja) | 2016-09-27 | 2024-09-02 | ボード オブ リージェンツ, ザ ユニヴァーシティー オブ テキサス システム | マイクロバイオームをモジュレートすることにより、免疫チェックポイント遮断療法を増強するための方法 |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| US11167018B2 (en) * | 2016-12-23 | 2021-11-09 | Keio University | Compositions and methods for the induction of CD8+ T-cells |
| KR20190127710A (ko) * | 2017-02-07 | 2019-11-13 | 캘리포니아 인스티튜트 오브 테크놀로지 | 헌팅톤병 및 레트 증후군에서의 장 미생물총의 조정 |
| WO2018187272A1 (en) | 2017-04-03 | 2018-10-11 | Gusto Global, Llc | Rational design of microbial-based biotherapeutics |
| JP7212945B2 (ja) | 2017-05-22 | 2023-01-26 | フォーディー ファーマ リサーチ リミテッド | 細菌株を含む組成物 |
| EP3630942B1 (en) | 2017-05-24 | 2022-11-30 | 4D Pharma Research Limited | Compositions comprising bacterial strain |
| TWI767013B (zh) | 2017-06-14 | 2022-06-11 | 英商4D製藥研究有限公司 | 包含細菌品系之組成物 |
| MA49373B1 (fr) | 2017-06-14 | 2021-02-26 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| MA49425A (fr) | 2017-06-14 | 2020-04-22 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| CN111448306B (zh) * | 2017-09-15 | 2023-10-27 | 深圳华大生命科学研究院 | 粪厌氧棒形菌(Anaerofustis stercorihominis)及其应用 |
| US10507221B2 (en) | 2017-11-09 | 2019-12-17 | Vedanta Biosciences, Inc. | Compositions and methods for the treatment of allergy |
| AU2018365071B2 (en) * | 2017-11-09 | 2025-09-11 | Vedanta Biosciences, Inc. | Compositions and methods for the treatment of allergy |
| EP4410954A3 (en) | 2017-12-11 | 2025-01-15 | Vedanta Biosciences, Inc. | Compositions and methods for suppressing pathogenic organisms |
| US11723934B2 (en) | 2018-02-09 | 2023-08-15 | Keio University | Compositions and methods for the induction of CD8+ T-cells |
| WO2019169168A1 (en) * | 2018-02-28 | 2019-09-06 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer using agathobaculum |
| CN112888447A (zh) | 2018-08-17 | 2021-06-01 | 韦丹塔生物科学股份有限公司 | 减少菌群失调和恢复微生物群系的方法 |
| TW202023590A (zh) * | 2018-08-17 | 2020-07-01 | 英商4D製藥研究有限公司 | 包含細菌菌株之組合物 |
| WO2020071463A1 (ja) * | 2018-10-04 | 2020-04-09 | 国立研究開発法人理化学研究所 | ILC2を標的としたIgA産生誘導方法 |
| US20220072101A1 (en) * | 2019-01-11 | 2022-03-10 | President and Fellows of Haravrd College | Harnessing inflammation to treat neurodevelopmental disorders |
| MX2022005157A (es) * | 2019-11-01 | 2022-08-31 | Uti Lp | Aprovechamiento de la energia de la microbiota y los metabolitos para el tratamiento del cancer. |
| GB202007452D0 (en) | 2020-05-19 | 2020-07-01 | Microbiotica Ltd | Threrapeutic bacterial composition |
| CN112899194B (zh) * | 2021-02-08 | 2022-07-12 | 澳优乳业(中国)有限公司 | 一株短双歧杆菌及其培养方法和用途 |
| EP4294413A1 (en) | 2021-02-18 | 2023-12-27 | Vedanta Biosciences, Inc. | Compositions and methods for suppressing pathogenic organisms |
| WO2024044787A2 (en) * | 2022-08-26 | 2024-02-29 | The Trustees Of Columbia University In The City Of New York | Treatment of metabolic syndrome and associated morbidities using intestinal th17 cells or intestinal th17 cell-derived molecules |
| JP7279983B1 (ja) | 2022-09-21 | 2023-05-23 | 学校法人近畿大学 | 腸内細菌培養組培地、及び腸内細菌培養方法。 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59128333A (ja) | 1983-01-07 | 1984-07-24 | Nisshin Flour Milling Co Ltd | 家禽用発育促進剤 |
| JP3269890B2 (ja) | 1993-08-25 | 2002-04-02 | 株式会社ヤクルト本社 | ワクチンの効果増強剤及び効果増強食品 |
| US6368586B1 (en) | 1996-01-26 | 2002-04-09 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers |
| US5951977A (en) | 1997-10-14 | 1999-09-14 | The United States Of America, As Represented By The Secretary Of Agriculture | Competitive exclusion culture for swine |
| US6319958B1 (en) | 1998-06-22 | 2001-11-20 | Wisconsin Alumni Research Foundation | Method of sensitizing microbial cells to antimicrobial compound |
| KR100671879B1 (ko) * | 1999-07-16 | 2007-01-19 | 가부시키가이샤 쇼에이 | 니트로이미다졸 함유 피부 질환용 외용제 |
| AUPQ899700A0 (en) * | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| TWI405851B (zh) * | 2002-02-21 | 2013-08-21 | Medimmune Llc | 間質肺病毒株及其作為疫苗調配物及作為表現抗原性序列之載體之應用 |
| CN101843614B (zh) * | 2002-08-26 | 2013-05-22 | S.L.A.制药有限公司 | 甲硝哒唑或其药学上可接受的衍生物的用途 |
| WO2006097949A1 (en) * | 2005-03-16 | 2006-09-21 | Actial Farmacêutica, Lda. | Mixture of at least 6 species of lactic acid bacteria and/or bifidobacteria in the manufacture of sourdough |
| JP5187642B2 (ja) | 2007-03-19 | 2013-04-24 | 森下仁丹株式会社 | 経口ワクチン |
| JP2010155801A (ja) * | 2008-12-26 | 2010-07-15 | Ajinomoto Co Inc | Il−17産生阻害剤及び炎症性腸疾患の治療若しくは予防剤 |
| WO2011079282A1 (en) | 2009-12-23 | 2011-06-30 | Vaxgene Corporation | Immunoprotection by oral administration of recombinant lactococcus lactis mini-capsules |
| JP2011032170A (ja) * | 2009-07-29 | 2011-02-17 | Morinaga Milk Ind Co Ltd | ヒト細胞il−17産生抑制剤 |
| KR101613600B1 (ko) * | 2009-12-21 | 2016-04-20 | 삼성전자주식회사 | 화상형성장치 및 xps 파일 식별방법 |
| FI20105478A0 (fi) | 2010-04-30 | 2010-04-30 | Valtion Teknillinen | Menetelmä tyypin 1 diabeteksen diagnosoimiseksi ja menetelmiä ja koostumuksia tyypin 1 diabeteksen puhkeamisen estämiseksi |
| WO2011151941A1 (ja) | 2010-06-04 | 2011-12-08 | 国立大学法人東京大学 | 制御性t細胞の増殖または集積を誘導する作用を有する組成物 |
| ES2993669T3 (en) | 2011-12-01 | 2025-01-03 | Univ Tokyo | Human-derived bacteria that induce proliferation or accumulation of regulatory t cells |
| US20140357499A1 (en) * | 2013-05-30 | 2014-12-04 | Washington University | METHODS OF LOW ERROR AMPLICON SEQUENCING (LEA-Seq) AND THE USE THEREOF |
| JP6617935B2 (ja) | 2014-04-10 | 2019-12-11 | 国立研究開発法人理化学研究所 | Th17細胞の誘導のための組成物及び方法 |
-
2015
- 2015-04-10 JP JP2017504545A patent/JP6617935B2/ja active Active
- 2015-04-10 WO PCT/JP2015/061771 patent/WO2015156419A1/en not_active Ceased
- 2015-04-10 CA CA2944846A patent/CA2944846C/en active Active
- 2015-04-10 EP EP15776630.4A patent/EP3129035B1/en active Active
- 2015-04-10 CN CN201580028607.3A patent/CN106659746A/zh active Pending
- 2015-04-10 AU AU2015244700A patent/AU2015244700B2/en active Active
- 2015-04-10 US US15/302,755 patent/US10300137B2/en active Active
- 2015-04-10 KR KR1020167031388A patent/KR102377396B1/ko active Active
- 2015-04-10 MX MX2016013247A patent/MX387331B/es unknown
-
2019
- 2019-04-05 US US16/375,935 patent/US20190290753A1/en not_active Abandoned
- 2019-10-30 JP JP2019197970A patent/JP2020014483A/ja active Pending
-
2020
- 2020-11-19 AU AU2020273293A patent/AU2020273293A1/en not_active Abandoned
-
2021
- 2021-05-14 US US17/321,131 patent/US11826424B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3129035B1 (en) | 2024-09-18 |
| WO2015156419A1 (en) | 2015-10-15 |
| KR102377396B1 (ko) | 2022-03-22 |
| CN106659746A (zh) | 2017-05-10 |
| US10300137B2 (en) | 2019-05-28 |
| EP3129035C0 (en) | 2024-09-18 |
| AU2015244700A1 (en) | 2016-11-24 |
| AU2020273293A1 (en) | 2020-12-17 |
| US20170028061A1 (en) | 2017-02-02 |
| US11826424B2 (en) | 2023-11-28 |
| JP6617935B2 (ja) | 2019-12-11 |
| EP3129035A4 (en) | 2018-03-28 |
| AU2015244700B2 (en) | 2020-08-27 |
| US20190290753A1 (en) | 2019-09-26 |
| JP2017515890A (ja) | 2017-06-15 |
| US20220072125A1 (en) | 2022-03-10 |
| MX2016013247A (es) | 2017-05-03 |
| KR20170015286A (ko) | 2017-02-08 |
| CA2944846A1 (en) | 2015-10-15 |
| EP3129035A1 (en) | 2017-02-15 |
| JP2020014483A (ja) | 2020-01-30 |
| CA2944846C (en) | 2023-01-03 |
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