MX380168B - Derivados de n-piridinil acetamida como inhibidores de la via de señalizacion wnt. - Google Patents

Derivados de n-piridinil acetamida como inhibidores de la via de señalizacion wnt.

Info

Publication number
MX380168B
MX380168B MX2017004639A MX2017004639A MX380168B MX 380168 B MX380168 B MX 380168B MX 2017004639 A MX2017004639 A MX 2017004639A MX 2017004639 A MX2017004639 A MX 2017004639A MX 380168 B MX380168 B MX 380168B
Authority
MX
Mexico
Prior art keywords
inhibitors
compounds
signaling pathway
wnt signaling
acetamide derivatives
Prior art date
Application number
MX2017004639A
Other languages
English (en)
Other versions
MX2017004639A (es
Inventor
Inder Bhamra
Craig Donoghue
Michael Mathieson
Richard Testar
Original Assignee
Redx Pharma Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1417832.1A external-priority patent/GB201417832D0/en
Priority claimed from GBGB1512279.9A external-priority patent/GB201512279D0/en
Application filed by Redx Pharma Plc filed Critical Redx Pharma Plc
Publication of MX2017004639A publication Critical patent/MX2017004639A/es
Publication of MX380168B publication Critical patent/MX380168B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención está relacionada a compuestos; más específicamente, la invención está relacionada a compuestos útiles como inhibidores de la vía de señalización Wnt; específicamente, los inhibidores de Porcupino (Porcn) son contemplados en la invención; además, la invención contempla procesos para preparar los compuestos y usos de los compuestos; los compuestos de la invención pueden por lo tanto ser utilizados en el tratamiento de condiciones mediadas por la vía de señalización Wnt, por ejemplo, para tratar cáncer, sarcoma, melanoma, cáncer de piel, tumores hematológicos, linfoma, carcinoma, y leucemia; o mejorar la efectividad de un tratamiento anti-cáncer.
MX2017004639A 2014-10-08 2015-10-08 Derivados de n-piridinil acetamida como inhibidores de la via de señalizacion wnt. MX380168B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1417832.1A GB201417832D0 (en) 2014-10-08 2014-10-08 Compounds
GBGB1512279.9A GB201512279D0 (en) 2015-07-14 2015-07-14 Compounds
PCT/GB2015/052943 WO2016055790A1 (en) 2014-10-08 2015-10-08 N-pyridinyl acetamide derivatives as wnt signalling pathway inhibitors

Publications (2)

Publication Number Publication Date
MX2017004639A MX2017004639A (es) 2017-07-17
MX380168B true MX380168B (es) 2025-03-12

Family

ID=54337305

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017004639A MX380168B (es) 2014-10-08 2015-10-08 Derivados de n-piridinil acetamida como inhibidores de la via de señalizacion wnt.

Country Status (22)

Country Link
US (4) US10202375B2 (es)
EP (2) EP4071150A1 (es)
JP (1) JP6588976B2 (es)
KR (1) KR102476667B1 (es)
CN (1) CN106795157B (es)
AU (1) AU2015329788B2 (es)
BR (1) BR112017007218B1 (es)
CA (1) CA2961740C (es)
CY (1) CY1125356T1 (es)
DK (1) DK3204381T3 (es)
ES (1) ES2922580T3 (es)
HR (1) HRP20220864T8 (es)
HU (1) HUE059537T2 (es)
LT (1) LT3204381T (es)
MX (1) MX380168B (es)
PL (1) PL3204381T3 (es)
PT (1) PT3204381T (es)
RS (1) RS63397B1 (es)
SG (1) SG11201702142UA (es)
SI (1) SI3204381T1 (es)
SM (1) SMT202200297T1 (es)
WO (1) WO2016055790A1 (es)

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SMT201900615T1 (it) 2014-10-08 2020-01-14 Redx Pharma Plc Derivati di acetammide n-piridinile come inibitori del percorso di segnalazione wnt
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WO2017189647A1 (en) * 2016-04-26 2017-11-02 Memorial Sloan Kettering Cancer Center Methods and compositions for the treatment of myelodysplastic syndrome
WO2019157085A2 (en) * 2018-02-06 2019-08-15 Vanderbilt University INHIBITION OF WNT/β-CATENIN SIGNALING IN THE TREATMENT OF OSTEOARTHRITIS
CR20200464A (es) 2018-03-08 2021-04-14 Incyte Corp Compuestos diólicos de aminopirazina como inhibidores de pi3k-y
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CN108640929B9 (zh) * 2018-06-14 2019-09-06 绍兴文理学院 3,4,5-三甲氧基取代含吡唑结构的螺[吲哚嗪-异噁唑啉]衍生物及其制备方法与应用
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WO2020125759A1 (zh) * 2018-12-21 2020-06-25 汇瀚医疗科技有限公司 作为wnt信号通路抑制剂的化合物及其医学应用
CN111620874B (zh) * 2019-02-28 2022-11-15 汇瀚医疗科技有限公司 取代5,6-双杂环氨基化合物作为wnt信号通路抑制剂及其治疗应用
CN111349093B (zh) * 2018-12-21 2021-07-02 汇瀚医疗科技有限公司 5,6-双环化合物作为wnt信号通路抑制剂及其医学应用
CN113024563B (zh) * 2019-12-24 2023-01-03 药康众拓(江苏)医药科技有限公司 嘧啶并五元杂环类化合物或其可药用的盐、异构体及其制备方法、药物组合物和用途
WO2021138450A1 (en) * 2019-12-30 2021-07-08 Buto Corporation Novel small molecule shc blockers for treating liver disease and metabolic disease
WO2023072263A1 (zh) * 2021-10-29 2023-05-04 南京明德新药研发有限公司 5-取代的吡啶-2(1h)-酮类化合物及其应用
WO2024022365A1 (zh) * 2022-07-28 2024-02-01 杭州阿诺生物医药科技有限公司 一种Wnt通路抑制剂化合物
CN120187430A (zh) 2022-11-04 2025-06-20 阿斯利康(瑞典)有限公司 用于治疗间质性肺病的n-吡啶基乙酰胺衍生物的口服制剂
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CN120943785B (zh) * 2025-10-17 2026-01-02 广州医科大学附属市八医院 一种化合物及其在制备具有抑制Wnt信号通路活性的药物中的应用

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WO2016055790A1 (en) 2016-04-14
DK3204381T3 (da) 2022-07-25
PT3204381T (pt) 2022-07-18
US10793562B2 (en) 2020-10-06
LT3204381T (lt) 2022-08-25
ES2922580T3 (es) 2022-09-16
BR112017007218B1 (pt) 2023-10-10
US20170298062A1 (en) 2017-10-19
CN106795157B (zh) 2019-07-23
HRP20220864T1 (hr) 2022-10-14
AU2015329788B2 (en) 2019-10-10
SI3204381T1 (sl) 2022-10-28
SMT202200297T1 (it) 2022-09-14
SG11201702142UA (en) 2017-04-27
PL3204381T3 (pl) 2022-08-29
HRP20220864T8 (en) 2023-02-03
CN106795157A (zh) 2017-05-31
HUE059537T2 (hu) 2022-11-28
US20190144447A1 (en) 2019-05-16
CA2961740A1 (en) 2016-04-14
CY1125356T1 (el) 2025-05-09
KR102476667B1 (ko) 2022-12-09
EP3204381B1 (en) 2022-05-25
EP4071150A1 (en) 2022-10-12
AU2015329788A1 (en) 2017-04-06
RS63397B1 (sr) 2022-08-31
JP6588976B2 (ja) 2019-10-09
EP3204381A1 (en) 2017-08-16
CA2961740C (en) 2023-03-07
BR112017007218A2 (pt) 2017-12-19
JP2017530985A (ja) 2017-10-19
MX2017004639A (es) 2017-07-17
US20200407356A1 (en) 2020-12-31
KR20170063948A (ko) 2017-06-08
US11459326B2 (en) 2022-10-04
US20230121489A1 (en) 2023-04-20
US10202375B2 (en) 2019-02-12

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