MX375798B - Endoproteasa específica para prolina. - Google Patents

Endoproteasa específica para prolina.

Info

Publication number
MX375798B
MX375798B MX2016015036A MX2016015036A MX375798B MX 375798 B MX375798 B MX 375798B MX 2016015036 A MX2016015036 A MX 2016015036A MX 2016015036 A MX2016015036 A MX 2016015036A MX 375798 B MX375798 B MX 375798B
Authority
MX
Mexico
Prior art keywords
polypeptide
seq
proline
sequence
specific endoprotease
Prior art date
Application number
MX2016015036A
Other languages
English (en)
Other versions
MX2016015036A (es
Inventor
Bruine-Paulus Angela De
Chantal Christis
Der Laan Jan Metske Van
Johanna Henrica Gerdina Maria Mutsaers
Martine Spaans
De Vondervoort Peter Jozef Ida Van
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2016015036A publication Critical patent/MX2016015036A/es
Publication of MX375798B publication Critical patent/MX375798B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/347—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of proteins from microorganisms or unicellular algae
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/66—Proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/70—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter
    • A23L2/84—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter using microorganisms or biological material, e.g. enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/195—Proteins from microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
    • A23L7/10—Cereal-derived products
    • A23L7/101—Addition of antibiotics, vitamins, amino-acids, or minerals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21026—Prolyl oligopeptidase (3.4.21.26), i.e. proline-specific endopeptidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fodder In General (AREA)
  • Peptides Or Proteins (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

La presente invención se relaciona con un polipéptido que tiene actividad de endoproteasa específica para prolina, seleccionado del grupo consistente de i. un polipéptido que comprende una secuencia de polipéptido madura de SEQ ID NO: 2; ii. un polipéptido que tiene al menos 70%, 75%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, de identidad con la secuencia de polipéptido maduro de SEQ ID NO: 2; iii. un polipéptido codificado por un ácido nucleico que hibrida bajo restricción media, preferiblemente bajo condiciones de restricción alta a la cadena complementaria de la secuencia de codificación del polipéptido maduro de SEQ ID NO:1; iv. un polipéptido codificado por un ácido nucleico que tiene al menos 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% o 100% de identidad con la secuencia de codificación de polipéptido maduro de SEQ ID NO: 1. La invención se relaciona adicionalmente con un método para producir el polipéptido y un proceso para la preparación de un producto alimenticio o de pienso en donde se utiliza el polipéptido.
MX2016015036A 2014-05-19 2015-05-19 Endoproteasa específica para prolina. MX375798B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14168866 2014-05-19
PCT/EP2015/061026 WO2015177171A1 (en) 2014-05-19 2015-05-19 Proline-specific endoprotease

Publications (2)

Publication Number Publication Date
MX2016015036A MX2016015036A (es) 2017-05-02
MX375798B true MX375798B (es) 2025-03-07

Family

ID=50732004

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016015036A MX375798B (es) 2014-05-19 2015-05-19 Endoproteasa específica para prolina.

Country Status (11)

Country Link
US (1) US10450554B2 (es)
EP (1) EP3146043B1 (es)
JP (1) JP6601630B2 (es)
CN (1) CN106459947B (es)
BR (1) BR112016026789B1 (es)
DK (1) DK3146043T3 (es)
EA (1) EA034253B1 (es)
ES (1) ES2744898T3 (es)
MX (1) MX375798B (es)
PL (1) PL3146043T3 (es)
WO (1) WO2015177171A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106459948B (zh) * 2014-06-03 2020-12-29 帝斯曼知识产权资产管理有限公司 脯氨酸特异性内切蛋白酶及其用途
CN110431224A (zh) 2017-03-13 2019-11-08 帝斯曼知识产权资产管理有限公司 锌双核簇转录调控因子缺陷型菌株
US20250304938A1 (en) 2022-05-16 2025-10-02 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2025012325A1 (en) 2023-07-11 2025-01-16 Dsm Ip Assets B.V. Protein arginine deiminase

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE294871T1 (de) 1994-06-30 2005-05-15 Novozymes Biotech Inc Nicht-toxisches, nicht-toxigenes, nicht- pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren
EP0979294B1 (en) 1997-04-11 2015-05-27 DSM IP Assets B.V. Gene conversion as a tool for the construction of recombinant industrial filamentous fungi
PL341760A1 (en) 1997-12-22 2001-05-07 Dsm Nv Expression cloning in mildew fungi
CN1940067A (zh) 1999-03-22 2007-04-04 诺沃奇梅兹有限公司 用于在真菌细胞中表达基因的启动子
PT1326957E (pt) * 2000-12-07 2004-09-30 Dsm Ip Assets Bv Metodo para a prevencao ou reducao de turvacao em bebidas
CA2437081C (en) 2000-12-07 2010-10-19 Dsm Ip Assets B.V. Protein hydrolysates enriched in peptides having a carboxy terminal proline residue
ES2361993T5 (es) 2002-02-14 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Tratamiento con enzimas de productos alimenticios para celiaquía
EP1511835B9 (en) * 2002-06-07 2015-02-25 DSM IP Assets B.V. Improved method for the prevention or reduction of haze in beverages
JP5328100B2 (ja) 2003-09-23 2013-10-30 ディーエスエム アイピー アセッツ ビー．ブイ． ペプチドおよびタンパク質を加水分解するためのプロリン特異的エンドプロテアーゼの使用
AU2006207463B2 (en) 2005-01-24 2011-03-17 Dsm Ip Assets B.V. Method for producing a compound of interest in a filamentous fungal cell
ES2534282T3 (es) 2006-06-29 2015-04-21 Dsm Ip Assets B.V. Un método para lograr la expresión polipeptídica mejorada
EP3868855A1 (en) 2006-07-13 2021-08-25 DSM IP Assets B.V. Improved brewing process
WO2009065862A1 (en) * 2007-11-23 2009-05-28 Dsm Ip Assets B.V. Improved bioactive peptide production
TW201000634A (en) 2008-05-30 2010-01-01 Dsm Ip Assets Bv Proline-specific protease
EP2421986A1 (en) 2009-04-22 2012-02-29 DSM IP Assets B.V. Process for the production of a recombinant polypeptide of interest
EP3293264A1 (en) 2009-07-22 2018-03-14 DSM IP Assets B.V. Improved host cell for the production of a compound of interest
WO2012174127A1 (en) * 2011-06-17 2012-12-20 Alvine Pharmaceuticals, Inc. Proteases for degrading gluten
WO2013007820A1 (en) 2011-07-14 2013-01-17 Dsm Ip Assets B.V. Screening method
US9631197B2 (en) * 2012-03-12 2017-04-25 Dsm Ip Assets B.V. Rasamsonia transformants
WO2013160316A1 (en) 2012-04-23 2013-10-31 Dsm Ip Assets B.V. Polypeptide expression method
WO2014202622A2 (en) * 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof

Also Published As

Publication number Publication date
WO2015177171A1 (en) 2015-11-26
US10450554B2 (en) 2019-10-22
EP3146043B1 (en) 2019-06-26
JP6601630B2 (ja) 2019-11-06
PL3146043T3 (pl) 2019-12-31
DK3146043T3 (da) 2019-09-23
CN106459947B (zh) 2024-05-14
EA201692327A1 (ru) 2017-02-28
BR112016026789A2 (pt) 2017-12-12
EP3146043A1 (en) 2017-03-29
JP2017515467A (ja) 2017-06-15
CN106459947A (zh) 2017-02-22
US20170081651A1 (en) 2017-03-23
MX2016015036A (es) 2017-05-02
EA034253B1 (ru) 2020-01-22
BR112016026789B1 (pt) 2023-05-02
ES2744898T3 (es) 2020-02-26

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