MX375528B - Variante del virus prrs, clon de adnc del virus europeo y sus usos. - Google Patents
Variante del virus prrs, clon de adnc del virus europeo y sus usos.Info
- Publication number
- MX375528B MX375528B MX2016007737A MX2016007737A MX375528B MX 375528 B MX375528 B MX 375528B MX 2016007737 A MX2016007737 A MX 2016007737A MX 2016007737 A MX2016007737 A MX 2016007737A MX 375528 B MX375528 B MX 375528B
- Authority
- MX
- Mexico
- Prior art keywords
- prrs
- virus
- variant
- european
- dna clone
- Prior art date
Links
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 title abstract 7
- 241000700605 Viruses Species 0.000 title abstract 5
- 241001465754 Metazoa Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000282898 Sus scrofa Species 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 229940125575 vaccine candidate Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10041—Use of virus, viral particle or viral elements as a vector
- C12N2770/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13199177 | 2013-12-20 | ||
| EP14175691 | 2014-07-03 | ||
| PCT/EP2014/078929 WO2015092058A1 (en) | 2013-12-20 | 2014-12-19 | Prrs virus variant, european prrs virus cdna clone, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016007737A MX2016007737A (es) | 2016-09-07 |
| MX375528B true MX375528B (es) | 2025-03-06 |
Family
ID=52347295
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016007737A MX375528B (es) | 2013-12-20 | 2014-12-19 | Variante del virus prrs, clon de adnc del virus europeo y sus usos. |
| MX2020010248A MX2020010248A (es) | 2013-12-20 | 2014-12-19 | Variante del virus prrs, clon de adnc del virus europeo y sus usos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020010248A MX2020010248A (es) | 2013-12-20 | 2014-12-19 | Variante del virus prrs, clon de adnc del virus europeo y sus usos. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10010601B2 (https=) |
| EP (2) | EP3591042B1 (https=) |
| JP (3) | JP6886291B2 (https=) |
| KR (2) | KR102446025B1 (https=) |
| CN (1) | CN105829528B (https=) |
| AU (2) | AU2014369774B2 (https=) |
| CA (1) | CA2930042C (https=) |
| DK (2) | DK3591042T5 (https=) |
| EA (1) | EA039060B1 (https=) |
| ES (2) | ES2940691T3 (https=) |
| HU (1) | HUE061768T2 (https=) |
| MX (2) | MX375528B (https=) |
| WO (1) | WO2015092058A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG192821A1 (en) | 2011-02-17 | 2013-09-30 | Boehringer Ingelheim Vetmed | Commercial scale process for production of prrsv |
| ES2550258T3 (es) | 2011-02-17 | 2015-11-05 | Boehringer Ingelheim Vetmedica Gmbh | Nueva cepa del PRRSV europea |
| EA039060B1 (ru) * | 2013-12-20 | 2021-11-29 | Бёрингер Ингельхайм Ветмедика Гмбх | Вариант вируса ppcc, способ его получения с помощью молекулы нуклеиновой кислоты, конструкции днк или клетки и его применение для лечения и профилактики ррсс |
| BR112019000887A2 (pt) | 2016-08-05 | 2019-04-30 | Hipra Scientific, S.L.U. | clone de cdna do vírus da síndrome reprodutiva e respiratória porcina e usos do mesmo |
| WO2020138761A1 (ko) * | 2018-12-27 | 2020-07-02 | 주식회사 바이오포아 | 돼지 생식기 및 호흡기 증후군 바이러스의 키메라 바이러스 및 이를 이용한 백신 |
| KR102335864B1 (ko) * | 2018-12-27 | 2021-12-06 | 주식회사 바이오포아 | 돼지 생식기 및 호흡기 증후군 바이러스의 키메라 바이러스 및 이를 이용한 백신 |
| CN119876049A (zh) * | 2019-08-29 | 2025-04-25 | 礼蓝美国公司 | 猪繁殖与呼吸综合征疫苗病毒 |
| CN110894243B (zh) * | 2019-12-16 | 2021-07-13 | 中国农业大学 | 一种猪蓝耳病毒嵌合抗原以及检测猪蓝耳病毒抗体的胶体金免疫层析试纸条 |
| MX2022007905A (es) * | 2019-12-31 | 2022-08-25 | Elixirgen Therapeutics Inc | Administracion transitoria basada en temperatura de acidos nucleicos y proteinas a celulas y tejidos. |
| JP2021153692A (ja) * | 2020-03-25 | 2021-10-07 | 株式会社三共 | 遊技機 |
| KR102319508B1 (ko) * | 2020-07-27 | 2021-10-28 | 연세대학교 산학협력단 | 인체 감염형 낙타 유래 메르스코로나바이러스 검출용 바이오마커 및 이의 용도 |
| CN113969267B (zh) * | 2021-11-15 | 2024-02-27 | 中国农业大学 | 一种猪繁殖与呼吸综合征突变病毒及其构建方法与应用 |
| WO2024077281A2 (en) * | 2022-10-06 | 2024-04-11 | Cornell University | Genotyping and sequencing assays for prrsv |
| KR20240146158A (ko) * | 2023-03-27 | 2024-10-08 | 주식회사 케어사이드 | 돼지생식기호흡기증후군 키메릭 바이러스 및 이를 이용한 백신 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3137631A (en) | 1959-12-01 | 1964-06-16 | Faberge Inc | Encapsulation in natural products |
| US3959457A (en) | 1970-06-05 | 1976-05-25 | Temple University | Microparticulate material and method of making such material |
| US4015100A (en) | 1974-01-07 | 1977-03-29 | Avco Everett Research Laboratory, Inc. | Surface modification |
| EP0000062A1 (en) | 1977-06-07 | 1978-12-20 | Joseph George Spitzer | Vapor tap valve for aerosol containers used with inflammable propellants, and container provided therewith |
| US4205060A (en) | 1978-12-20 | 1980-05-27 | Pennwalt Corporation | Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use |
| ZA864879B (en) | 1985-07-08 | 1987-03-25 | Wallone Region | Vaccines and diagnostics derived from boving diarrhoea virus |
| NZ222465A (en) | 1986-11-07 | 1992-11-25 | Pasteur Institut | Nanb (non a, non b hepatitis viral) antigen |
| DE69201441T3 (de) | 1991-06-06 | 2008-12-04 | Boehringer Ingelheim Vetmedica Gmbh | Erreger der mysteriösen schweinekrankheit,impfstoff-zusammensetzungen und diagnose kits. |
| US6042830A (en) | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
| AU2684792A (en) | 1991-10-14 | 1993-05-21 | Akzo Nobel N.V. | Porcine reproductive respiratory syndrome vaccine and diagnostic |
| FR2686097B1 (fr) | 1992-01-14 | 1994-12-30 | Rhone Merieux | Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie. |
| US5695766A (en) | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
| ES2074950B1 (es) | 1993-09-17 | 1996-03-16 | Iberica Cyanamid | Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda. |
| ES2165405T3 (es) | 1994-04-11 | 2002-03-16 | Akzo Nobel Nv | Cepas de vacuna europeas del virus del sindrome reproductor y respiratorio porcino (prrsv). |
| GB2289279B (en) | 1994-05-13 | 1998-09-16 | Iberica Cyanamid | Diagnostic kits and vaccines containing recombinant PRRSV proteins |
| DE69632658T2 (de) | 1995-03-14 | 2005-06-09 | Akzo Nobel N.V. | Expression in der selben Zelle von Polypeptide vom schweinen reproduktiven und respiratorischen Syndrom |
| ES2102971B1 (es) | 1996-01-25 | 1998-03-01 | Hipra Lab Sa | Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion. |
| US5866401A (en) | 1996-03-01 | 1999-02-02 | Schering Corporation | Porcine reproductive and respiratory syndrome vaccine |
| ATE199022T1 (de) | 1996-10-09 | 2001-02-15 | Akzo Nobel Nv | Europäische vakzinstämme des fortplanzungs- atmungs-syndromsvirus des sweins (prrsv) |
| EP0839912A1 (en) | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| US20040224327A1 (en) | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| EP1882696A3 (en) | 1997-05-06 | 2008-03-05 | Boehringer Ingelheim Vetmedica Gmbh | PRRSV antigenic sites identifying peptide sequences of PRRS virus for use in vaccines or diagnostic assays |
| CA2290220C (en) * | 1998-12-22 | 2013-11-19 | Pfizer Products Inc. | An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof |
| CA2366072C (en) | 1999-03-08 | 2007-07-10 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Prrsv vaccines |
| MXPA01010681A (es) | 1999-04-22 | 2003-08-20 | Us Agriculture | Vacuna de sindrome respiratorio y reproductiva porcina a base de ja-142 aislado. |
| WO2001059077A1 (en) | 2000-02-08 | 2001-08-16 | Regents Of The University Of Minnesota | Porcine reproductive and respiratory syndrome virus and methods of use |
| EP1156111A1 (en) | 2000-05-19 | 2001-11-21 | Stichting Dienst Landbouwkundig Onderzoek | Chimeric arterivirus-like particles |
| EP1397498A1 (en) | 2001-05-21 | 2004-03-17 | ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. | Delections in arterivirus replicons |
| ATE557082T1 (de) | 2002-04-05 | 2012-05-15 | Boehringer Ingelheim Vetmed | Sequenz positionen zur anpassung bei prrsv |
| US7722878B2 (en) | 2004-06-17 | 2010-05-25 | Boehringer Ingelheim Vetmedica, Inc. | PRRSV subunit vaccines |
| US7632636B2 (en) | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
| KR20070096019A (ko) | 2005-01-13 | 2007-10-01 | 베링거잉겔하임베트메디카게엠베하 | 향상된 ｐｒｒｓ 백신 |
| WO2008121958A1 (en) | 2007-04-02 | 2008-10-09 | Boehringer Ingelheim Vetmedica, Inc. | Use of prrsv vaccines to reduce pcv2 viremia |
| ES2389748T3 (es) * | 2007-06-25 | 2012-10-31 | South Dakota State University | Virus del síndrome reproductivo y respiratorio porcino de tipo 1 norteamericano recombinante y métodos de uso |
| KR101653177B1 (ko) | 2008-08-25 | 2016-09-01 | 베링거잉겔하임베트메디카인코퍼레이티드 | 고병원성 돼지 생식기 및 호흡기 증후군(ｈｐ ｐｒｒｓ)에 대한 백신 |
| WO2010084648A1 (ja) * | 2009-01-20 | 2010-07-29 | シャープ株式会社 | 照明装置、表示装置、及びテレビ受信装置 |
| EP2558118B1 (en) | 2010-04-16 | 2019-06-05 | Universiteit Gent | Cross-protecting vaccine for porcine reproductive and respiratory syndrome virus |
| ES2550258T3 (es) * | 2011-02-17 | 2015-11-05 | Boehringer Ingelheim Vetmedica Gmbh | Nueva cepa del PRRSV europea |
| SG192821A1 (en) | 2011-02-17 | 2013-09-30 | Boehringer Ingelheim Vetmed | Commercial scale process for production of prrsv |
| EP2737059A1 (en) | 2011-07-29 | 2014-06-04 | Boehringer Ingelheim Vetmedica GmbH | Novel prrs virus inducing type i interferon in susceptible cells |
| EP3466443B1 (en) * | 2012-02-14 | 2020-12-16 | Boehringer Ingelheim Animal Health USA Inc. | Recombinant poxviral vectors expressing both rabies and ox40 proteins, and vaccines made therefrom |
| CA2872789C (en) * | 2012-05-17 | 2019-09-03 | Zoetis Llc | Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning |
| WO2014150822A2 (en) | 2013-03-15 | 2014-09-25 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use |
| CN105829906B (zh) * | 2013-12-19 | 2020-11-03 | 皇家飞利浦有限公司 | 具有水/脂肪分离的相位敏感的反转恢复mri |
| EA039060B1 (ru) | 2013-12-20 | 2021-11-29 | Бёрингер Ингельхайм Ветмедика Гмбх | Вариант вируса ppcc, способ его получения с помощью молекулы нуклеиновой кислоты, конструкции днк или клетки и его применение для лечения и профилактики ррсс |
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2014
- 2014-12-19 EA EA201600476A patent/EA039060B1/ru unknown
- 2014-12-19 HU HUE19165389A patent/HUE061768T2/hu unknown
- 2014-12-19 ES ES19165389T patent/ES2940691T3/es active Active
- 2014-12-19 DK DK19165389.8T patent/DK3591042T5/da active
- 2014-12-19 DK DK14827219.8T patent/DK3083947T3/da active
- 2014-12-19 WO PCT/EP2014/078929 patent/WO2015092058A1/en not_active Ceased
- 2014-12-19 US US15/105,760 patent/US10010601B2/en active Active
- 2014-12-19 EP EP19165389.8A patent/EP3591042B1/en active Active
- 2014-12-19 ES ES14827219T patent/ES2729838T3/es active Active
- 2014-12-19 CA CA2930042A patent/CA2930042C/en active Active
- 2014-12-19 KR KR1020217019360A patent/KR102446025B1/ko active Active
- 2014-12-19 AU AU2014369774A patent/AU2014369774B2/en active Active
- 2014-12-19 JP JP2016540591A patent/JP6886291B2/ja active Active
- 2014-12-19 CN CN201480068965.2A patent/CN105829528B/zh active Active
- 2014-12-19 EP EP14827219.8A patent/EP3083947B1/en active Active
- 2014-12-19 KR KR1020167019672A patent/KR102270344B1/ko active Active
- 2014-12-19 MX MX2016007737A patent/MX375528B/es active IP Right Grant
- 2014-12-19 MX MX2020010248A patent/MX2020010248A/es unknown
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2018
- 2018-06-01 US US15/995,560 patent/US10639364B2/en active Active
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2019
- 2019-12-20 JP JP2019230014A patent/JP2020054380A/ja not_active Withdrawn
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2021
- 2021-02-25 AU AU2021201224A patent/AU2021201224B2/en active Active
- 2021-03-24 JP JP2021049537A patent/JP7158523B2/ja active Active
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